Cysteine and Glycine-Rich Protein 3 Proteins (CSRP3)

CSRP3 encodes a member of the CSRP family of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. Additionally we are shipping CSRP3 Antibodies (88) and CSRP3 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CSRP3 8048 P50461
CSRP3 13009 P50462
CSRP3 117505 P50463
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Top CSRP3 Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,749.58
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,749.58
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Details
Escherichia coli (E. coli) Human His-SUMO Tag 100 μg 11 Days
$356.40
Details
Wheat germ Human GST tag 10 μg 11 to 12 Days
$414.29
Details
Yeast Rat His tag   1 mg 60 to 71 Days
$2,467.67
Details
Yeast Cow His tag   1 mg 60 to 71 Days
$2,467.67
Details

CSRP3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine)

Rat (Rattus)

Top referenced CSRP3 Proteins

  1. Human CSRP3 Protein expressed in HEK-293 Cells - ABIN2719040 : Nagai-Okatani, Minamino: Aberrant Glycosylation in the Left Ventricle and Plasma of Rats with Cardiac Hypertrophy and Heart Failure. in PLoS ONE 2016 (PubMed)

More Proteins for Cysteine and Glycine-Rich Protein 3 (CSRP3) Interaction Partners

Human Cysteine and Glycine-Rich Protein 3 (CSRP3) interaction partners

  1. Previous results along with the newly identified homozygous CSRP3 truncating variants in two unrelated hypertrophic cardiomyopathy (HCM) patients suggest that the association of CSRP3 as a validated HCM-causing gene require additional studies and those CSRP3 variants could result in HCM with an autosomal recessive inheritance rather than with an autosomal dominant transmission as usually reported on HCM.

  2. MLP contributes to the maintenance of cardiomyocyte cytoarchitecture by a mechanism involving its self-association and actin filament cross-linking.

  3. study reports the discovery of an alternative splice variant of muscle lim protein encoded by the CSRP3 gene, designated as MLP-b, showing distinct expression in neuromuscular disease and direct roles in actin dynamics and muscle differentiation

  4. KLF5 reverses hhLIM function from anti-proliferation to pro-proliferation through its interaction with hhLIM on the cyclin E promoter.

  5. The CSRP3-W4R mutation causes cardiomyopathy and heart failure in patients and engineered knock-in animals.

  6. CSRP3 is involved in cardiac mechanosensory processes, is localized to the sarcomeric Z-disc and human mutations cause cardiomyopathy(DCM)and heart failure.

  7. Mutations in the CRP3/MLP gene can cause hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM).

  8. CSRP3, MUSTN1, SIX1, and FBXO32 expression changes in response to lengthening and shortening contractions in human muscle

  9. A myocardial actin-binding protein that increases actin cytoskeleton stability by promoting bundling of actin filaments.

  10. These findings suggest that hhLIM is a typical LIM family member with powerful transcription activation.

  11. Study used linkage analysis and identified a CSRP3 missense mutation in a large German family affected by hypertrophic cardiomyopathy.

  12. CSRP3 mutation was found involved in hypertrophic cardiomyopathy.

  13. The structure of both LIM domains of human MLP by nuclear magnetic resonance spectroscopy.

  14. CRP3/MLP is primarily expressed in arterial smooth muscle cells and that stretch is the main stimulus for CRP3/MLP induction in veins exposed to arterial haemodynamic conditions.

  15. Complete chemical shift assignment was achieved for the first LIM domain and for most of the second domain, the N-terminal and C-terminal linker and part of the intervening linker.

  16. MLP binds directly to CFL2 in human cardiac and skeletal muscles.

Mouse (Murine) Cysteine and Glycine-Rich Protein 3 (CSRP3) interaction partners

  1. we identify a novel role for Csrp3 expression in skeletal muscle in the development of obesity-induced insulin resistance

  2. Ablation of MLP protein (and MYBPC3) protected mice from developing the dilated cardiomyopathy phenotype.

  3. Cardiac overexpression of muscle LIM protein does not modulate the heart's response to various forms of pathological stress.

  4. Loss of MLP leads to dilated cardiomyopathy and hearts of surviving MLP knockout mice show transient changes of intracellular calcium handling.

  5. Report a common MLP (muscle LIM protein) variant associated with a hypertrophic cardiomyopathy and heart failure phenotype, and skeletal muscle pathology.

  6. Reduced MLP-calcineurin signaling predisposes to adverse remodeling after myocardial infarct.

  7. results indicate that the progression to heart failure in the MLPKO model may be driven by diastolic myocardial dysfunction and abnormal passive properties rather than systolic dysfunction

  8. This detailed physiological characterization during a phase of rapid anatomical remodeling suggests that systolic function in the MLP(-/-) mice may temporarily improve as a result of alterations in chamber compliance, which are mediated by dilatation.

  9. Mice with knockout of muscle-LIM protein exhibit prolongation of atrial and ventricular conduction and an increased ventricular vulnerability.

  10. MLP binds directly to CFL2 in human cardiac and skeletal muscles.

Cow (Bovine) Cysteine and Glycine-Rich Protein 3 (CSRP3) interaction partners

  1. data support the high potential of the CSRP3 as a marker gene for the improvement of growth performance and carcass traits in selection programs

Pig (Porcine) Cysteine and Glycine-Rich Protein 3 (CSRP3) interaction partners

  1. CSRP3 coding gene from porcine muscle was isolated and characterized and Phylogenic analyses demonstrated that CSRP3 diverged first and is distinguished from two other members, CSRP1 and CSRP2.

Xenopus laevis Cysteine and Glycine-Rich Protein 3 (CSRP3) interaction partners

  1. is only expressed in the differentiated heart during early development and is expressed in a subset of other striated muscles during later stages

CSRP3 Protein Profile

Protein Summary

This gene encodes a member of the CSRP family of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this protein is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Mutations in this gene are thought to cause heritable forms of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in humans. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene.

Gene names and symbols associated with CSRP3

  • cysteine and glycine rich protein 3 (CSRP3)
  • cysteine and glycine-rich protein 3 (Csrp3)
  • cysteine and glycine rich protein 3 (Csrp3)
  • cysteine and glycine rich protein 3 (csrp3)
  • cysteine and glycine-rich protein 3 (cardiac LIM protein) (csrp3)
  • cysteine and glycine rich protein 3 L homeolog (csrp3.L)
  • CLP protein
  • CMD1M protein
  • CMH12 protein
  • CRP3 protein
  • CSRP3 protein
  • csrp3-a protein
  • LMO4 protein
  • MLP protein
  • MMLP protein
  • zgc:103468 protein

Protein level used designations for CSRP3

LIM domain only 4 , cardiac LIM domain protein , cysteine and glycine-rich protein 3 , muscle LIM protein , LIM domain protein, cardiac , cardiac LIM protein , cysteine-rich protein 3 , CRP3 , cysteine- and glycine-rich protein 3 , Cysteine and glycine-rich protein 3 , Muscle LIM protein , csrp3b , cysteine and glycine-rich protein 3 (cardiac LIM protein)

GENE ID SPECIES
8048 Homo sapiens
13009 Mus musculus
117505 Rattus norvegicus
540407 Bos taurus
610946 Canis lupus familiaris
100196456 Salmo salar
100337687 Sus scrofa
422979 Gallus gallus
450005 Danio rerio
473442 Pan troglodytes
702466 Macaca mulatta
100229240 Taeniopygia guttata
373825 Xenopus laevis
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