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Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Additionally we are shipping Cysteine and Histidine-Rich Domain (CHORD)-Containing 1 Proteins (10) and many more products for this protein.
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Human Polyclonal CHORDC1 Primary Antibody for WB - ABIN1881199
Gano, Simon: A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein. in Molecular & cellular proteomics : MCP 2010
Show all 3 Pubmed References
Human Polyclonal CHORDC1 Primary Antibody for ICC, IF - ABIN4298077
Zhao, Xu, Zhou, Wang, Xie, Ren, Liu, Zhu: MicroRNA-26b inhibits hepatitis B virus transcription and replication by targeting the host factor CHORDC1 protein. in The Journal of biological chemistry 2014
NF-kappaB activation in breast cancer cells depends on the presence of the CHORDC1 gene product Morgana.
suppression of miR (show MLXIP Antibodies)-26b expression up-regulates its target gene CHORDC1, which increases HBV enhancer/promoter activities and promotes viral transcription, gene expression, and replication
morgana causes PTEN destabilization, by inhibiting ROCK activity
Chp-1 (show CHP Antibodies) and melusin (show ITGB1BP2 Antibodies) can interact with cochaperones PP5 (show PPP5C Antibodies) and Sgt1 (show SUGT1 Antibodies) and with each other in an ATP-dependent manner
A novel ADP-dependent HSP90 (show HSP90 Antibodies) interaction with the cysteine- and histidine-rich domain (CHORD)-containing protein CHORDC1, is characterized.
This paper described the cloning of a barley CHORD containing protein, but it also described the CHORD containing proteins in other species including human and characterized the CHORD domains.
Morgana silencing blocks metastasis formation in breast cancer mouse models and this phenotype is reverted by IkappaBalpha (show NFKBIA Antibodies) downregulation.
Loss of Morgana expression is associated with drug resistance and chronic myeloid leukemia (show BCL11A Antibodies).
Chp-1 and melusin (show ITGB1BP2 Antibodies) can interact with cochaperones PP5 (show PPP5C Antibodies) and Sgt1 (show SUGT1 Antibodies) and with each other in an ATP-dependent manner
Overexpression of morgana/CHP-1 in NIH3T3 cells leads to the increased stress resistance of the cells.
Morgana/chp-1 downregulation promotes the interaction between ROCK II (show ROCK2 Antibodies) and nucleophosmin (show NPM1 Antibodies), leading to an increased ROCK II (show ROCK2 Antibodies) kinase activity, which results in centrosome amplification.
Full length sequence, gene structure and expression of Chp-1.
The first biochemical evidence demonstrating that mammalian Chp-1 is a novel Hsp90 (show HSP90 Antibodies)-interacting protein.
results suggest that Chordc1 mRNA is under complex and widespread transcriptional regulation during development and implicate Chordc1 in circadian and/or homeostatic mechanisms in mammalian brain.
Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis (By similarity).
CHORD-containing protein 1
, chord domain-containing protein 1
, cysteine and histidine-rich domain (CHORD)-containing 1
, cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1
, cysteine and histidine-rich domain-containing protein 1
, protein morgana
, CHORD domain-containing protein 1
, cysteine and histidine-rich domain (CHORD)-containing, zinc binding protein 1
, CHORD containing protein-1