Cytochrome B-245, beta Polypeptide Proteins (CYBB)

Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. Additionally we are shipping CYBB Antibodies (133) and CYBB Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CYBB 1536 P04839
CYBB 13058 Q61093
Rat CYBB CYBB 66021  
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Top CYBB Proteins at

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Escherichia coli (E. coli) Human T7 tag,His tag 100 μg Log in to see 15 to 18 Days

CYBB Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,
Mouse (Murine)

More Proteins for Cytochrome B-245, beta Polypeptide (CYBB) Interaction Partners

Zebrafish Cytochrome B-245, beta Polypeptide (CYBB) interaction partners

  1. The nox1 (show NOX1 Proteins), nox2/cybb expression in zebrafish during early nervous system development from 12 to 48 hours post fertilization

Rabbit Cytochrome B-245, beta Polypeptide (CYBB) interaction partners

  1. Data indicate that NADPH oxidase (show NOX1 Proteins) NOx2 inhibition attenuates endoplasmic reticulum (ER) stress and apoptosis.

Human Cytochrome B-245, beta Polypeptide (CYBB) interaction partners

  1. indicated that miR (show MLXIP Proteins)-27b exerted its protective role in retinal pigment epithelium cells under PDGF (show PDGFA Proteins)-BB stimulation was partially through regulation of Nox2

  2. Findings show that under elevated glucose concentration, NOX2 is activated by SMIT1 (show SLC5A3 Proteins) triggering ROS (show ROS1 Proteins) production in the heart.

  3. Human post-mortem and animal studies have identified elevated NOX2 and NOX4 levels in the injured brain, suggesting that these two NOXs are involved in the pathogenesis of Traumatic brain injury (TBI)

  4. To further elucidate the mAb 7D5 epitope on human gp91(phox) , chimeric DNA expressed human and mouse gp91(phox) recombinant protein were constructed. The fusion proteins were immunostained for mAb 7D5 and analyzed by FACS and western blot analysis.

  5. Phorbol 12-myristate-13-acetate-stimulated NOX2-NIS (NOX-specific Insertion Sequence) phosphorylation by ATM (show ATM Proteins) kinase causes a dynamic switch that deactivates NOX2 activity. This downregulation may be defective in NOX2-NIS3 mutant because of the absence of Ser486.

  6. This study identifies one novel mutation in the IL2RG (show IL2RG Proteins) gene and another, previously described mutation in the CYBB genes. It is the first report establishing a diagnosis of X-SCID (show PRKDC Proteins) and X-CGD using WES in Chinese patients.

  7. In a male patient suffering from X-linked chronic granulomatous disease (CGD) we found a c.389G>T mutation in exon 5 of the CYBB gene.

  8. The potency of RTK inhibition by BJ-1301 was lower than that of sunitinib (a multi-RTK inhibitor), but the inhibition of downstream signaling pathways (e.g., ROS (show ROS1 Proteins) generation) and subsequent biological changes (e.g., NOX2 induction) by BJ-1301 was superior

  9. Translated to human pathophysiology, (show ALDH2 Proteins)we found increased gp91(phox) expression in endomyocardial biopsies of Alcoholic cardiomyopathy (ACM) patients. In conclusion, ACM is promoted by ACA-driven mitochondrial dysfunction and can be improved by ablation of NOX2/gp91(phox). NOX2/gp91(phox) therefore might be a potential pharmacological target to treat ACM.

  10. We demonstrated that small interfering RNA (siRNA)-mediated knockdown of PRR (show PVRL1 Proteins), Nox2 and Nox4 (show NOX4 Proteins) significantly reduced the HG-induced stimulation of VEGF (show VEGFA Proteins). On the other hand, Nox4 (show NOX4 Proteins) overexpression significantly potentiated PRR (show PVRL1 Proteins)-induced stimulation of VEGF (show VEGFA Proteins) under hyperglycemia in ARPE-19 cells.

Cow (Bovine) Cytochrome B-245, beta Polypeptide (CYBB) interaction partners

  1. Data indicate that the efficiency of NADPH oxidase (show NOX1 Proteins) enzymatic activity is higher at endoplasmic reticulum (ER).

  2. A p47(phox) and Src kinase activation of peroxide production by Nox2 appears to be an important contributor to vascular contractile mechanisms mediated through activation of protein kinase C

Mouse (Murine) Cytochrome B-245, beta Polypeptide (CYBB) interaction partners

  1. the study reports a novel mechanistic pathway of leptin (show LEP Proteins)-mediated renal inflammation that is dependent on NOX-2-miR21 axis in ectopic manifestations underlying non-alcoholic fatty liver disease-induced co-morbidities

  2. Whereas the oxidative burst in myeloid cells is mainly catalyzed by the NOX2 isotype, in epithelial cells other isotypes of the NADPH (show FDXR Proteins) oxidases family are involved, especially NOX4 (show NOX4 Proteins)

  3. Proximal point of bifurcation in cardiac insulin (show INS Proteins) signaling through the simultaneous activation of both NOX2 and NOX4 (show NOX4 Proteins) was identified. Each NOX isoform generates H2O2 in cardiac myocytes with distinct time courses, with H2O2 derived from NOX2 augmenting Akt (show AKT1 Proteins)-dependent metabolic effects of insulin (show INS Proteins), while H2O2 from NOX4 (show NOX4 Proteins) blocks beta adrenergic increases in inotropy.

  4. AIF (show AIFM1 Proteins) activated AMPK (show PRKAA1 Proteins)-dependent Nox2 signaling pathway.

  5. Nox2 may be a therapeutic target for AII (show ARG2 Proteins)-induced skeletal muscle atrophy.

  6. These results indicated that integrin CD11b (show ITGAM Proteins) mediates alpha-synuclein-induced NOX2 activation through a RhoA (show RHOA Proteins)-dependent pathway.

  7. These results showed that CR3 (show ITGAM Proteins) regulated Nox2 activation and dopaminergic neurodegeneration through a Src (show SRC Proteins)-Erk (show EPHB2 Proteins)-dependent pathway in a two pesticide-induced Parkinson's disease (PD) model, providing novel insights into the immune pathogenesis of PD.

  8. High levels of NOX2 were found in mouse adult neurogenic brain regions. NOX2-deficient brain showed decrease in neuroprecursor cell pool and lowered expression of genes involved in neural differentiation.

  9. Echocardiography revealed that ALDH-2 (show ALDH2 Proteins)(-/-)/gp91(phox-/-) mice were protected from ACA-overload-induced HF after 5 weeks of 2% EtOH-diet, demonstrating that NOX2-derived O2(*-) contributes to the development of ACM

  10. Nox2 activation favors thioredoxin-1 (TRX-1 (show TXN Proteins))/p40phox (show NCF4 Proteins) interaction, which leads to exclusion of TRX-1 (show TXN Proteins) from the nucleus.

Pig (Porcine) Cytochrome B-245, beta Polypeptide (CYBB) interaction partners

  1. These results suggested that resveratrol strongly enhances the RA-induced O2(-)-generating activity via up-regulation of gp91-phox gene expression in U937 cells.

  2. sub-vasomotor concentration of ET-1 (show EDN1 Proteins) leads to vascular dysfunction by impairing endothelium-dependent NO-mediated dilation via p38 (show MAPK14 Proteins) kinase-mediated production of superoxide from NADPH oxidase (show NOX1 Proteins) following ETA receptor activation

  3. Reactive oxygen species generated by NADPH oxidase (show NOX1 Proteins) contribute to the aberrant pulmonary arterial responses in piglets exposed to 3 days of hypoxia.

  4. Upregulation of PPAR-gamma and NADPH oxidases are involved in restenosis.

CYBB Protein Profile

Protein Summary

Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase\; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole.

Gene names and symbols associated with CYBB

  • cytochrome b-245, beta polypeptide (chronic granulomatous disease) (cybb)
  • cytochrome b-245, beta polypeptide (cybb)
  • cytochrome b-245 heavy chain (CYBB)
  • cytochrome b-245, beta polypeptide L homeolog (cybb.L)
  • cytochrome b-245, beta polypeptide (CYBB)
  • cytochrome b-245 beta polypeptide (CYBB)
  • cytochrome b-245 beta chain (CYBB)
  • cytochrome b-245, beta polypeptide (Cybb)
  • cytochrome b-245 beta chain (Cybb)
  • cytochrome b-245, beta polypeptide (chronic granulomatous disease) (CYBB)
  • NADPH oxidase heavy chain subunit (GP91-PHOX)
  • AMCBX2 protein
  • C88302 protein
  • Cgd protein
  • CGD91-phox protein
  • CYBB protein
  • Cyd protein
  • GP91-1 protein
  • Gp91-phox protein
  • GP91PHOX protein
  • NOX1 protein
  • Nox2 protein
  • p91-PHOX protein
  • zgc:64144 protein

Protein level used designations for CYBB

cytochrome b-245, beta polypeptide , gp91 , NADPH oxidase 2 , cytochrome b-245, beta polypeptide (chronic granulomatous disease) , Cytochrome b-245 heavy chain , NADPH oxidase heavy chain subunit , NADPH oxidase 1 , NADPH oxidase flavocytochrome b subunit , cytochrome b-245 heavy chain , gp91-phox , CGD91-phox , cytochrome b(558) subunit beta , cytochrome b558 subunit beta , heme-binding membrane glycoprotein gp91phox , neutrophil cytochrome b 91 kDa polypeptide , p22 phagocyte B-cytochrome , superoxide-generating NADPH oxidase heavy chain subunit , gp91-1 , endothelial type gp91-phox , predicted NADPH oxidase-2

393386 Danio rerio
595081 Xenopus (Silurana) tropicalis
696542 Macaca mulatta
444353 Xenopus laevis
100036757 Ovis aries
100270807 Salmo salar
100008801 Oryctolagus cuniculus
1536 Homo sapiens
418581 Gallus gallus
281112 Bos taurus
13058 Mus musculus
66021 Rattus norvegicus
491825 Canis lupus familiaris
397108 Sus scrofa
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