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Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 (CYP2D6) ELISA Kits

CYP2D6 encodes a member of the cytochrome P450 superfamily of enzymes. Additionally we are shipping Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 Antibodies (182) and Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 Proteins (15) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
CYP2D6 1565 P10635
CYP2D6    
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Top Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 ELISA Kits at antibodies-online.com

Showing 2 out of 8 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Rat 0.65 ng/mL 1.56 ng/mL - 100 ng/mL 96 Tests 13 to 16 Days
$800.00
Details
Human 0.034 ng/mL 0.156-10 ng/mL   96 Tests 2 to 3 Days
$713.90
Details

More ELISA Kits for Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 Interaction Partners

Human Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 (CYP2D6) interaction partners

  1. The study demonstrated that the simultaneous presence of TMDR1, A CYP2D6*4 and A NAT2*7 alleles robustly increased the risk of developing ulcerative colitis by 3.49-fold. The current study suggests that CYP2D6*4 and MDR1 3435 C/T gene polymorphisms may be risk factors for UC susceptibility.

  2. Genotype-determined and directly measured impaired levels of CYP2D6 activity were associated with elevated risk of therapeutic failure. These findings suggest a natural variability in CYP2D6-dependent metabolism of primaquine as a key determinant of therapeutic efficacy against latent P vivax malaria

  3. Allergic individuals with chemical sensitivity differed from allergic patients without chemical sensitivity with regard to the distribution of genotype and phenotype of CYP2D6 polymorphisms

  4. Genetic Variation of CYP2D6 Gene in the Bosnian Population

  5. The impact of CYP2D6 polymorphisms in the tamoxifen resistance mechanism remains unclear. The CYP2D6 gene seems to contribute to decreasing the efficacy of tamoxifen, while the main mechanism responsible for therapy failure, morbidity, and mortality is the progression of the disease

  6. Critical appraisal of the literature provided evidence for the value of comprehensive CYP2D6 genotyping panels in guiding treatment decisions for non-metastatic ER-positive breast cancer patients. Based on this information, it is recommended that alternatives to standard tamoxifen treatments may be considered in CYP2D6 poor or intermediate metabolizers.

  7. Plasma exposures of tolterodine and its active moiety were significantly increased in subjects with reduced CYP2D6 activity.

  8. Polymorphisms associated with the metabolization process of morphine and other opioid drugs are very relevant in opioid titration and ethnic subgroup differences which have to be taken into account (particularly, for the recommendation grade A for the CYP2D6 polymorphism)

  9. despite the small sample size, maternal prenatal exposure to pesticides, paternal occupation as a traffic warden/police officer, and CYP2D6*4 polymorphism could play a role in the etiology of childhood acute leukemia.

  10. These findings indicate that Chelidonine acted as a mechanism-based inactivator of CYP2D6 and the observed effects may induce potential drug-drug interactions

  11. Studied herb-drug interactions of mistletoe extracts with endoxifen and their associations with inhibition of CYP3A4/5 and CYP2D6 in vitro.

  12. Investigated CYP2D6 alleles, tandem repeats and copy number variants in a Hong Kong population.

  13. Our results indicate that the altered enzyme activity can be attributed to changes in the hydrogen bonding network within the active site, and local structural differences in flexibility, position and shape of the binding pocket. In particular, the increased (CYP2D6*53) or the decreased (CYP2D6*17) activity seems to be related to a change in dynamics of mainly the BC loop due to a modified hydrogen bonding network around

  14. Studied the association of CYP2D6 polymorphisms and phenotypes with Vivax malaria recurrence in patients from the Western Brazilian Amazon, following chloroquine/primaquine combined therapy.

  15. prevalence of CYP2D6*4 1934AA genotype was higher in total HIV patients compared to healthy controls; similarly, CYP2D6*4 1934AA genotype was much more prevalent in HIV patients without hepatotoxicity compared to healthy controls; there was no significant difference in genotype or allele frequencies of CYP2D6*4 1934G/A polymorphism between the patients with hepatotoxicity and those without or healthy controls

  16. CYP2D6 polymorphisms increase vulnerability to tramadol-induced hepatotoxicity.

  17. Hot flash severity during tamoxifen therapy can not be accounted for by CYP2D6 genotype or observed plasma concentration of tamoxifen, 4-hydroxytamoxifen, or endoxifen

  18. found a novel haplotype which involves 100C>T without 4180G>C

  19. There was a significant difference in baseline neuropsychological scores among schizophrenia patients with three genotypes of CYP2D6 rs1135840. Also, rs1135840 showed a significant association with change in scores after risperidone treatment. This reflected a smaller change in GG genotype than C allele carriers; comparison of these two genotype groups gave a significant difference.

  20. The ratio dehydro-aripiprazole/aripiprazole was influenced by CYP2D6 phenotype

Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 (CYP2D6) Antigen Profile

Antigen Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug\; sparteine and propafenone, both anti-arrythmic drugs\; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population\; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with CYP2D6

  • cytochrome P450 family 2 subfamily D member 6 (CYP2D6) antibody
  • cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6) antibody
  • cytochrome 2D6 (CYP2D6) antibody
  • cytochrome P450, family 2, subfamily D, polypeptide 6 (cyp2d6-b) antibody
  • cytochrome P450 family 2 subfamily D member 6 S homeolog (cyp2d6.S) antibody
  • cytochrome P450 family 2 subfamily D member 6 (cyp2d6) antibody
  • cytochrome P450 2D6 (CYP2D6) antibody
  • cytochrome P450 2D6-like (LOC100988273) antibody
  • CPD6 antibody
  • CYP2D antibody
  • cyp2d2 antibody
  • CYP2D6 antibody
  • cyp2d6-a antibody
  • CYP2D7AP antibody
  • CYP2D7BP antibody
  • CYP2D7P2 antibody
  • CYP2D8P2 antibody
  • CYP2D42 antibody
  • CYP2DL1 antibody
  • CYPIID6 antibody
  • MGC64445 antibody
  • P450-DB1 antibody
  • P450C2D antibody
  • P450DB1 antibody

Protein level used designations for CYP2D6

cytochrome P450 2D6 , cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2 , cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2 , cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising), polypeptide 7 pseudogene 2 , cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolising), polypeptide 8 pseudogene 2 , cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6 , cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing)-like 1 , cytochrome P450-DB1 , debrisoquine 4-hydroxylase , flavoprotein-linked monooxygenase , microsomal monooxygenase , xenobiotic monooxygenase , CYPIID6 , cytochrome P450 CYP2D42 , cytochrome P450, family 2, subfamily D, polypeptide 6 , cytochrome P450 2D6-like

GENE ID SPECIES
1565 Homo sapiens
470228 Pan troglodytes
678691 Macaca mulatta
100500743 Felis catus
379479 Xenopus laevis
446878 Xenopus laevis
548436 Xenopus (Silurana) tropicalis
100568286 Ovis aries
100988273 Pan paniscus
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