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The protein encoded by CRLF2 is a receptor for thymic stromal lymphopoietin (TSLP). Additionally we are shipping CRLF2 Antibodies (131) and CRLF2 Proteins (17) and many more products for this protein.
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Family-based whole genome analysis of a family with hereditary pulmonary alveolar proteinosis revealed a homozygous deletion that disrupts CSF2RA (show CSF2RA ELISA Kits), CRLF2, and IL3RA (show IL3RA ELISA Kits) gene in the pseudoautosomal region of the X chromosome in the affected child and one of asymptomatic siblings.
TSLP (show TSLP ELISA Kits) expression on the basophil membrane of patients with severe asthma was not significantly different from healthy controls.
high CRLF2 expression works with the IKZF1 deletion to drive oncogenesis of acute lymphoblastic leukemia
this study shows that CRLF2 over-expression is a poor prognostic marker in children with high risk T-cell acute lymphoblastic leukemia
data suggest that this high frequency of genetic aberrations in the context of a high CRLF2 expression could contribute to the high risk of relapse in P2RY8/CRLF2- and IGH/CRLF2-positive acute lymphoblastic leukemia.
CRLF2 overexpression is associated with childhood B-cell acute lymphoblastic leukemia.
CRLF2 gene rearrangement is associated with acute lymphoblastic leukemia.
TSLPR levels were found to be significantly higher in asthmatic than in nonasthmatic children. TSLPR expression in non-allergic asthmatic and allergic asthmatic groups was found to be significantly higher than in non-allergic nonasthmatic group
In adult B-cell acute lymphoblastic leukemia without recurrent fusion genes , high CRLF2 expression is associated with distinct clinico-biological features and an unfavourable prognosis
CD4 (show CD4 ELISA Kits)+ T cells from atopic dermatitis patients directly interacted with TSLP (show TSLP ELISA Kits) to produce a higher amount of IL-4 (show IL4 ELISA Kits) than those from normal subjects, and this action was attenuated with anti-TSLPR antibody
these results suggest that TSLP (show TSLP ELISA Kits)-TSLPR signaling is pivotal in the induction of nasal respiratory immunity against pathogenic pneumococcal infection
A novel mouse xenograft model to study the role of TSLP (show TSLP ELISA Kits)-induced CRLF2 signals in normal and malignant human B lymphopoiesis has been developed.
High-cholesterol diet increased TSLPR expression and atherosclerosis. High-dose ticagrelor moderated this trend. It modulated platelet activity and atherosclerosis mediated by TSLPR, potentially through the PI3K/Akt (show AKT1 ELISA Kits) signal pathway.
Activating thymic stromal lymphopoietin (show TSLP ELISA Kits) promotes atherosclerosis by inducing Th17/Treg imbalance through TSLPR signaling in a mouse model.
Suggest that Treg defects in ApoE (show APOE ELISA Kits)(-/-) mice might partially be attributed to the disruption of TSLP (show TSLP ELISA Kits)-TSLPR-LAP signaling in epithelial cells and dendritic cells.
The structure of the mouse TSLP (show TSLP ELISA Kits)-mediated signaling complex reveals how TSLP (show TSLP ELISA Kits) establishes extensive interfaces with its cognate receptor (TSLPR).
TSLPR helps to create a permissive microenvironment for the development and pulmonary metastasis of mammary carcinoma in a mouse model using implanted 4T1 tumour cells.
A previously unrecognized role was found for TSLP (show TSLP ELISA Kits)/TSLPR signaling in type 2 immunity as an important enhancer for the development of alternately activated macrophages as well as for chemokine (show CCL1 ELISA Kits) production.
mice deficient in TSLP receptors on LCs abrogated the induction of OVA-specific IgE levels upon epicutaneous OVA sensitization.
Increased susceptibility to autoimmune gastritis in thymic stromal lymphopoietin receptor-deficient mice.
The protein encoded by this gene is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Two transcript variants encoding different isoforms have been found for this gene.
cytokine receptor-like factor 2
, P2RY8/CRLF2 fusion
, TSLP receptor
, cytokine receptor CRL2 precusor
, cytokine receptor-like 2
, thymic stromal lymphopoietin protein receptor
, thymic stromal lymphopoietin receptor
, thymic stromal-derived lymphopoietin receptor
, cytokine receptor-like molecule 2
, delta 1
, lymphocyte antigen 114
, thymic stromal-derived lymphopoietin, receptor
, transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
, type I cytokine receptor delta 1