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DAO encodes the peroxisomal enzyme D-amino acid oxidase.
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Human D Amino Acid Oxidase ELISA Kit for Sandwich ELISA - ABIN423900
Jagannath, Marinova, Monoranu, Walitza, Grünblatt: Expression of D-Amino Acid Oxidase (DAO/DAAO) and D-Amino Acid Oxidase Activator (DAOA/G72) during Development and Aging in the Human Post-mortem Brain. in Frontiers in neuroanatomy 2017
The mutant G allele of the C2029G DAO (show ABP1 ELISA Kits) polymorphism was significantly more frequent in patients with migraine (P=.044). The OR of migraine for carriers of the mutant G allele of DAO (show ABP1 ELISA Kits) compared to wild-type homozygous women was 1.6 (95% CI, 1.1-2.1).
The study provides significant evidence for epistatic interactions among DAOA (show DAOA ELISA Kits) and DAO (show ABP1 ELISA Kits) gene in the development of schizophrenia. These results provide additional evidence and indicate that the DAOA (show DAOA ELISA Kits) gene and DAOA (show DAOA ELISA Kits)-DAO (show ABP1 ELISA Kits) gene-gene interactions might play a role for schizophrenia in a Taiwanese sample.
pLG72 interacts with neosynthesized d-amino acid oxidase (hDAAO), promoting its inactivation and degradation. In this work, we used low-resolution techniques to characterize the surface topology of the hDAAO-pLG72 complex.
The DAO (show ABP1 ELISA Kits) gene was a susceptibility gene for schizophrenia and the genomic region between intron 1 and intron 8 may harbor functional genetic variants, which may influence the mRNA expression of DAO (show ABP1 ELISA Kits) and neurocognitive functions in schizophrenia.
In the brain, the concentration of D-serine stored in cells is defined by the activity of D-amino acid oxidase.
Accumulation of d-serine contributes to an ALS pathogenesis, and DAO might be a common therapeutic target for ALS.
Data suggest that neuronal DAAO is a long-lived protein: peroxisomal fraction of DAAO is degraded via lysosomal/endosomal pathway, whereas cytosolic fraction of DAAO is ubiquitinated and targeted to proteasome pathway.
Data suggest that acyclovir (ACV) can serve as an active site probe to study the structural basis of temperature-induced conformational changes of d-Amino acid oxidase (DAO).
The results suggest that DAO (show ABP1 ELISA Kits), which is involved in the N-methyl-d-aspartate receptor (show GRIN1 ELISA Kits) regulation, signaling and glutamate (show GRIN1 ELISA Kits) metabolism, is the master gene of the genetic associations and interactions underlying schizophrenia.
study suggests that NMDA receptor-mediated signalling genes, DAO (show ABP1 ELISA Kits), PPP3CC, DTNBP1 (show DTNBP1 ELISA Kits) might be involved in schizophrenia pathogenic mechanisms related to gender
This work provides the most complete baseline analysis of L- and D-amino acids in the brains of wild-type and mutant mice lacking D-amino acid oxidase activity.
findings reveal that DAO is a microbiota-regulated host innate immune factor that modulates growth of both pathogens and commensals, primarily in the small intestine
some significant in vivo effects of DAOR199W on motor neuron function (i.e. kyphosis and loss of motor neurons) were detected which were most marked in females and could contribute to the earlier onset of neurological signs in double transgenic females compared to SOD1G93A littermates, highlighting the importance of recognizing gender effects present in animal models of ALS
Long-term spatial memory is unaltered in Dao-/- mice.
Dao-/- mice demonstrated enhanced spatial recognition memory and no sleep or circadian rhythm disruption.
In d-Amino acid oxidase (-/-) mice, approximately twice as many Dopamine-like neurons fired in a bursting pattern than in DAO(+/-) or DAO(+/+) mice. Data provide the first direct evidence that DAO modulates VTA DA neuron activity
The retinal levels of d-serine are tightly controlled during the first week of postnatal life and vary according to deficiencies in either DAO/
DAO deficiency reduces D-serine level in retina and increases NMDA receptor expression.
D-amino acids and DAO have pivotal neurotransmission functions in the central nervous system. (Review)
D-Amino acid oxidase-induced oxidative stress, 3-bromopyruvate and citrate inhibit angiogenesis, exhibiting potent anticancer effects.
DAO suppressed the growth of Staphylococcus aureus in a manner that depended on the concentration of DAO and D-amino acid in vitro; results suggest that DAO, together with myeloperoxidase (show MPO ELISA Kits), may play an important role in antibacterial systems in mammals
expression of Histamine N-Methyltransferase (show HNMT ELISA Kits) and Diamine Oxidase (show ABP1 ELISA Kits) in porcine tissues
The thermostable mutant DAO from porcine kidney by a single amino acid substitution, F42C, was stable at 55 degrees C, while the wild-type enzyme was stable only up to 45 degrees C.
tadpoles contained high concentrations of D-proline close to the final developmental stage and nearly no D-amino acids were detected in the adult frog, indicating that D-amino acid oxidase functions in metamorphosis.
This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known\; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia.
D-amino acid oxidase
, D-amino-acid oxidase
, D-amino acid oxidase 1
, D-amino-acid oxidase 1
, D-amino-acid oxidase-like
, LOW QUALITY PROTEIN: D-amino-acid oxidase