DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 50 Proteins (DDX50)

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box enzyme that may be involved in ribosomal RNA synthesis or processing. This gene and DDX21, also called RH-II/GuA, have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. This gene has pseudogenes on chromosomes 2, 3 and 4. Alternative splicing of this gene generates multiple transcript variants, but the full length nature of all the other variants but one has not been defined.

• DExD-box helicase 50 (DDX50)
• DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 (Ddx50)
• DExD-box helicase 50 (Ddx50)
• DExD-box helicase 21 (DDX21)

• 4933429B04Rik protein
• 8430408E17Rik protein
• DDX21 protein
• DDX50 protein
• GU2 protein
• Show all synonym aliases
• GUB protein
• mcdrh protein
• RH-II protein
• RH-II/GuB protein

ATP-dependent RNA helicase DDX50 , DEAD box protein 50 , RNA helicase II/Gu beta , gu-beta , malignant cell derived RNA helicase , nucleolar protein GU2 , DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 50 , Gubeta , RH-II/Gubeta , DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 , DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 , ATP-dependent RNA helicase DDX50-like , DEAD-box helicase 50