anti-DEP Domain Containing 2 (DEPDC2) Antibodies

Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Additionally we are shipping DEP Domain Containing 2 Kits (6) and DEP Domain Containing 2 Proteins (4) and many more products for this protein.

Gene Name	GeneID	UniProt
DEPDC2	80243	Q70Z35
DEPDC2	109294	Q3LAC4
DEPDC2

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Top anti-DEP Domain Containing 2 Antibodies at antibodies-online.com

Showing 9 out of 10 products:

Catalog No.	Reactivity	Host	Conjugate	Application	Quantity	Supplier	Delivery	Price	Details
ABIN2791874	Cow	Rabbit	Un-conjugated	WB	100 μL	Log in to see	2 to 3 Days	$289.00	Details
ABIN529238	Human	Mouse	Un-conjugated	WB	50 μg	Log in to see	11 to 12 Days	$440.00	Details
ABIN5079008	Human	Rabbit	Un-conjugated	ICC, IF	100 μL	Log in to see	10 to 13 Days	$491.63	Details
ABIN4347296	Human	Rabbit	Un-conjugated	IHC, IHC (p)	0.1 mL	Log in to see	10 to 13 Days	$491.63	Details
ABIN1837462	Human	Rabbit	Un-conjugated	WB	50 μg	Log in to see	7 to 9 Days	$551.83	Details
ABIN2598261	Human	Mouse	Un-conjugated	WB	50 μg	Log in to see	7 to 9 Days	$837.83	Details
ABIN2751158	Human	Rabbit	FITC	ELISA, WB	100 μg	Log in to see	1 to 2 Days	$572.00	Details
ABIN2751157	Human	Rabbit	Un-conjugated	ELISA, WB	100 μg	Log in to see	1 to 2 Days	$485.57	Details
ABIN5558713	Human	Rabbit	Biotin	ELISA, WB	100 μg	Log in to see	1 to 2 Days	$572.00	Details

DEPDC2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes	Applications	Host	Conjugate
Human	, ,	,	,
Mouse (Murine)			,
Cow (Bovine)

More product categories related to DEP Domain Containing 2 Antibody

More Antibodies against DEP Domain Containing 2 Interaction Partners

Human DEP Domain Containing 2 (DEPDC2) interaction partners

MiR (show MLXIP Antibodies)-338-3p suppresses the TNF-alpha (show TNF Antibodies)-induced lipogenesis in sebocytes by targeting PREX2a and down-regulating PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) signaling.
Data suggest that PREX1 (show PREX1 Antibodies) and PREX2 share similarities in amino acid sequence, domain structure, activation by PIP(3) [phosphatidylinositol 3,4,5-triphosphate] and G-protein-coupled receptors beta/gamma subunits; expression of PREX1 (show PREX1 Antibodies) and PREX2 is altered in many cancers. [REVIEW]
complex signaling mechanisms that involve PREX2, PI3K/AKT/PTEN and downstream epigenetic machinery to deregulate expression of key cell cycle regulators
PREX2 was identified as a frequently mutated gene in human melanoma. .. mutation of PREX2 can accelerate human melanoma growth.
The rapid tumor onset observed in this replication attempt, compared to the original study, makes the detection of accelerated tumor growth in PREX2 expressing NRAS (show NRAS Antibodies)(G12D) melanocytes extremely difficult.
Elevated PREX2 protein expression is associated with pathogenesis of hepatocellular carcinoma.
The results of the present study suggested that PREX2a may act as an oncogene (show RAB1A Antibodies) in osteosarcoma via the inhibition of PTEN activity and activation of PI3K (show PIK3CA Antibodies) signaling.
findings identify PREX2 as a mediator of NRAS-mutant melanoma development that acts through the PI3K/PTEN/Akt pathway to regulate gene expression of a cell cycle regulator
second messengers activate the Rac1 signal, which sets in motion a cascade whereby PAKs phosphorylate and negatively regulate PREX2 to decrease Rac1 activation.
PREX2 mutants are likely selected in cancer to escape PTEN-mediated inhibition of invasion.

Mouse (Murine) DEP Domain Containing 2 (DEPDC2) interaction partners

complex signaling mechanisms that involve PREX2, PI3K/AKT/PTEN and downstream epigenetic machinery to deregulate expression of key cell cycle regulators
P-REX2 PH-domain-mediated inhibition of PTEN has a role in regulating insulin (show INS Antibodies) sensitivity and glucose homeostasis
This study demonistrated that the P-Rex2, a GEF (show ARHGEF2 Antibodies) that specifically activates Rac (show AKT1 Antibodies) small GTPases, is expressed in a cell- and synapse-specific manner in the retina.
PI3K/P-Rex/Rac (show AKT1 Antibodies) pathway is required for late phase long-term potentiation in the mouse cerebellum
P-Rex1 (show PREX1 Antibodies) and P-Rex2 are important regulators of Purkinje cell morphology and cerebellar function

DEP Domain Containing 2 (DEPDC2) Antigen Profile

Protein Summary

Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein- coupled receptors and phosphoinositide 3-kinase (By similarity).

Gene names and symbols associated with DEPDC2

phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 (PREX2) antibody
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 (Prex2) antibody

6230420N16Rik antibody
AI316880 antibody
AI553603 antibody
C030045D06Rik antibody
D430013K02 antibody
DEP.2 antibody
Depdc2 antibody
P-Rex2 antibody

Protein level used designations for DEPDC2

DEP domain-containing protein 2 , PtdIns(3,4,5)-dependent Rac exchanger 2 , phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein , DEP domain containing 2 , ptdIns(3,4,5)-dependent Rac exchanger 2

GENE ID	SPECIES
80243	Homo sapiens
109294	Mus musculus

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