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May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Additionally we are shipping DET1 and DDB1 Associated 1 Proteins (8) and and many more products for this protein.
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Dog (Canine) Polyclonal DDA1 Primary Antibody for ELISA - ABIN4267544
Olma, Roy, Le Bihan, Sumara, Maerki, Larsen, Quadroni, Peter, Tyers, Pintard: An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases. in Journal of cell science 2009
surveyed the spectrum of G protein coupling of dDA1 and Damb, and we confirmed that both receptors can couple to Gs to stimulate cAMP synthesis
The results indicate that DDA1 promotes lung cancer progression, potentially through promoting cyclins and cell cycle progression.
Data indicate that DET1- and DDB1-associated protein 1 (DDA1)-mediated tumor progression is associated with the activation of the NF-kappa B (NFkappaB)/COP9 signalosome 2(CSN2)/glycogen synthase kinase3beta (GSK3beta) pathway.
the c-Abl non-receptor kinase phosphorylates DDB1 at residue Tyr-316 to recruit a small regulatory protein, DDA1, leading to increased substrate ubiquitination
PCIA1 gene expression correlates with tumor formation, invasion and metastasis
Cells depleted of Dda1 spontaneously accumulated double-stranded DNA breaks in a similar way to Cul4A-, Cul4B- or Wdr23-depleted cells, indicating that Dda1 interacts physically and functionally with cullin-RING E3 ligases complexes.
May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD- E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins (By similarity).
DET1- and DDB1-associated protein 1
, cross-immune reaction antigen PCIA1
, placenta cross-immune reaction antigen 1
, DET1 and DDB1 associated 1 L homeolog
, DET1- and DDB1-associated protein 1 b