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DCHS1 is a member of the cadherin superfamily whose members encode calcium-dependent cell-cell adhesion molecules. Additionally we are shipping and many more products for this protein.
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Dachsous1b cadherin regulates actin and microtubule cytoskeleton during early zebrafish embryogenesis.
zebrafish Dchs1b is required for atrioventricular canal development
Dchs1-Fat4 (show FAT4 Antibodies) planar cell polarity pathway controls cell orientation in the early skeletal condensation to define the shape and relative dimensions of the mouse sternum.
Fat4 (show FAT4 Antibodies) and Dachsous1 are critical regulators of lymphatic valve morphogenesis.
novel mechanisms of Fat4 (show FAT4 Antibodies)-Dchs1 signalling have evolved to control cell proliferation within the developing vertebrae.
Stromal Fat4 (show FAT4 Antibodies) acts non-autonomously with Dchs1/2 to restrict the nephron progenitor pool.
Dchs1 is a Fat4 (show FAT4 Antibodies) receptor in stromal signaling essential for kidney development.
DCHS1 deficiency in mitral valve prolapse patient mitral valve interstitial cells (MVICs), as well as in Dchs1(+/-) mouse MVICs, result in altered migration and cellular patterning, supporting these processes as aetiological underpinnings for the disease
These findings suggest that Fat and Dachsous self-bend due to the loss of Ca(2 (show CA2 Antibodies)+)-binding amino acids from specific EC-EC (show QPCT Antibodies) linkers, and can therefore adapt to confined spaces.
Dchs1 and Fat4 (show FAT4 Antibodies) function as a ligand-receptor pair during murine development, and novel requirements for Dchs1-Fat4 (show FAT4 Antibodies) signaling in multiple organs are identified
data are compatible with conservation and sub-functionalization of dachsous 1, Fj, and Fat signaling in higher vertebrates
Results highlight the importance of the Fat4 (show FAT4 Antibodies)-Dachsous1-Pals1 (show MPP5 Antibodies) complex in organizing the apical membrane architecture of neural progenitor cells.
The infant was diagnosed with van (show TNIP1 Antibodies) Maldergem syndrome on the basis of the clinical features and this was subsequently confirmed with genetic analysis, which indicated a homozygous mutation (c.7204G>A p. D2402N ) in the DCHS1 gene
Study shows that when key regulators during mammalian cerebral cortical development are disrupted due to DCHS1-FAT4 (show FAT4 Antibodies) mutations, functional cerebral asymmetries are stronger.
In sum, we establish Dchs1 as a component of the membrane domain surrounding the ciliary base. This suggests a specific role of Dchs1 in PCP (show PRCP Antibodies)-dependent organization of ciliary function and a possible role in lung disease.
findings show that mutations in genes encoding the receptor-ligand cadherin pair DCHS1 and FAT4 (show FAT4 Antibodies) lead to a recessive syndrome in humans that includes periventricular neuronal heterotopia
This gene is a member of the cadherin superfamily whose members encode calcium-dependent cell-cell adhesion molecules. The encoded protein has a signal peptide, 27 cadherin repeat domains and a unique cytoplasmic region. This particular cadherin family member is expressed in fibroblasts but not in melanocytes or keratinocytes. The cell-cell adhesion of fibroblasts is thought to be necessary for wound healing.
, dachsous 1 (Drosophila)
, cadherin-related family member 6
, fibroblast cadherin 1
, fibroblast cadherin FIB1
, fibroblast cadherin-1
, protein dachsous homolog 1
, protocadherin 16