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Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Additionally we are shipping Defensin, beta 104A Antibodies (12) and Defensin, beta 104A Proteins (8) and many more products for this protein.
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Expression of hBD-1, hBD-2, hBD-3, and hBD-4 in healthy and chronic periodontitis gingiva.
there is a significant link between innate immunity deregulation through disruption of cationic peptides (hBDs) and the potential development of colon cancer.
Beta-defensin 104 displays antimicrobial activity against S. carnosus, E. coli, S. cerevisiae, and P. aeruginosa (strong).
TFF3 activated the epithelial cells in culture to produce beta defensins 2 (hBD2) and beta defensins 4
Data suggest an activation of b-defensin-4 induction, in human knee meniscus by the osteoarthritis inflammatory process as a result of an endogenous antibiotic defense mechanism accompanied by an intrinsic effort of tissue remodeling.
Our results suggest that copy number variation of DEFB4 may not contribute to the pathogenesis of Behcet's disease.
Analysis of the DEFB4 promoter region shows remarkably high density of sequence variabilities.
The variations in the genes encoding human beta-defensin-1 and -2 may be associated with the risk of severe acute pancreatitis.
Data show that beta-defensin cluster (DEFB4, DEFB103 and DEFB104) varied between 2 and 9 copies per genome, and high copy numbers (>4) were underrepresented among patients, suggesting that increased copy numbers could protect from CD.
We report here the application of small ubiquitin-related modifier (SUMO) fusion technology to the expression and purification of cationic antibacterial peptide hBD4.
This study demonstrates, the involvement of NOD1 and DEFB4 in direct killing of Helicobacter pylori bacteria by epithelial cells and confirms the importance of NOD1 in host defence mechanisms against cagPAI(+)Helicobacter pylori infection.
The mRNA level of the beta defensin 4 did not differ significantly between the two subgroups.
elevated DEFB4 copy number is a risk factor for Crohn's disease
There is an association of four common DEFB104 haplotypes with the risk of prostate cancer in two independent patient cohorts.
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 104, DEFB104A and DEFB104B, in head-to-head orientation. This gene, DEFB104A, represents the more centromeric copy.
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