Desmocollin 2 (DSC2) ELISA Kits

The protein encoded by DSC2 is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. Additionally we are shipping Desmocollin 2 Antibodies (84) and Desmocollin 2 Proteins (15) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
DSC2 1824 Q02487
Anti-Mouse DSC2 DSC2 13506 P55292
Anti-Rat DSC2 DSC2 291760  
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Top Desmocollin 2 ELISA Kits at antibodies-online.com

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Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.107 ng/mL 0.31 ng/mL - 20 ng/mL 96 Tests Log in to see 13 to 16 Days
$736.84
Details

More ELISA Kits for Desmocollin 2 Interaction Partners

Human Desmocollin 2 (DSC2) interaction partners

  1. Desmocollin-2 genetic variant contributes to Arrhythmogenic Right Ventricular Cardiomyopathy

  2. PKP3 overexpression increases the stability of other desmosomal proteins independently of the increase in DSC2 levels and regulates desmosome formation and stability by a multimodal mechanism affecting transcription, protein stability and cell border localization of desmosomal proteins.

  3. The cardiac specific DSC2 transgenic mice develop severe biventricular cardiomyopathy.

  4. A novel missense mutation (c.1090 G > A/p.V364 M) of DSC2 was identified in a Chinese family with arrhythmogenic right ventricular cardiomyopathy.

  5. Data suggest juxtamembrane regions/domains of desmocollin-2 (DSC2), plakophilin 2 (PKP2), and plakophilin 3 (PKP3) are involved in desmosome formation in epithelial cells; DSC2 participates in desmosome formation in absence of desmoglein 2 (DSG2).

  6. Oxidized low-density lipoprotein attenuated desmoglein 1 and desmocollin 2 expression in human umbilical vein endothelial cells.

  7. DSC2 promoter methylation is associated with Breast Cancer.

  8. Homozygous founder mutation in DSC2 gene identified among Italian arrhythmogenic cardiomyopathy probands, providing evidence of the occurrence of recessive DSC2 mutations presenting with biventricular forms of the disease.

  9. Desmocollin-2 mutations are described for dilated cardiomyopathy and arrhythmogenic right ventricular cardiomyopathy, as well. Desmocollin-2 mutation was described in a case of arrhythmogenic biventricular cardiomyopathy

  10. a novel Nrf2-miR-29-Dsc2 axis controls desmosome function and cutaneous homeostasis

  11. ECG reliably identifies homozygous p.Gln554X desmocollin-2 carriers and may be useful as an initial step in the screening of high-risk Hutterites.

  12. DSC2 may be involved in the regulation of the invasive behavior of cells by a mechanism that controls cellcell attachment and cytoskeleton rearrangement

  13. Data demonstrate that partner desmosomal cadherins Dsg2 and Dsc2 play opposing roles in controlling colonic carcinoma cell proliferation through differential effects on EGFR signaling.

  14. Low expression of DSC 1, 2, and 3 was observed in 55, 54, and 79 % of liver metastases.

  15. Case of arrhythmogenic right ventricular cardiomyopathy with a previously unreported desmocollin-2 mutation (c.712_714delGAT). This genetic variant displays autosomal recessive inheritance without the cutaneous manifestations.

  16. Reduced cardiac desmoglein-2 and desmocollin-2 levels appear to be specifically associated with Arrhythmogenic right ventricular Dysplasia/cardiomyopathy, independent of underlying mutations.

  17. A homozygous truncation mutation, c.1660C>T (p.Q554X) in desmocollin-2 (DSC2) was idnetified in affected individuals and determined a carrier frequency of this mutation of 9.4% among 1535 Schmiedeleut Hutterites.

  18. results suggest that abnormal activation of beta-catenin contributes to adenomyosis development through the induction of epithelial-mesenchymal transition

  19. High expression of desmocollin 1 (DSC1) was observed in 41.6%, DSC2 in 58.0%, DSC3 in 61.4%, E-cadherin in 71.4%, CDX2 in 58.0%, PITX1 in 55.0%, CDK4 in 0.2%, TLE1 in 1.3%, Factor H in 42.5%, and MDM2 in 0.2% of colorectal carcinomas.

  20. DSC2 is a useful immunohistochemical marker for separation of Urothelial carcinoma with squamous differentiation from pure Urothelial carcinoma

Mouse (Murine) Desmocollin 2 (DSC2) interaction partners

  1. Downregulation of DSC2 is associated with arrhythmogenic cardiomyopathy.

  2. Cardiac specific overexpression of desmocollin-2 induces necrosis, acute inflammation and patchy cardiac fibrotic remodeling leading to fulminant biventricular cardiomyopathy.

  3. Data demonstrate that partner desmosomal cadherins Dsg2 and Dsc2 play opposing roles in controlling colonic carcinoma cell proliferation through differential effects on EGFR signaling.

  4. plakoglobin (Pg) in conjunction with lymphoid enhancer-binding factor 1 (Lef-1) differentially regulates the proximal promoters of Dsc2 and Dsc3

Desmocollin 2 (DSC2) Antigen Profile

Antigen Summary

The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11. Alternative splicing results in two transcript variants encoding distinct isoforms.

Gene names and symbols associated with Desmocollin 2 (DSC2) ELISA Kits

  • desmocollin 2 (DSC2) antibody
  • desmocollin 2 (Dsc2) antibody
  • ARVD11 antibody
  • AW228162 antibody
  • CDHF2 antibody
  • DG2 antibody
  • DGII/III antibody
  • DSC2 antibody
  • Dsc2a antibody
  • Dsc2b antibody
  • DSC3 antibody

Protein level used designations for Desmocollin 2 (DSC2) ELISA Kits

cadherin family member 2 , desmocollin-2 , desmosomal glycoprotein II/III , epithelial type 2 desmocollin , desmocollin type 2 , desmocollin 2 , desmocollin-2-like

GENE ID SPECIES
1824 Homo sapiens
13506 Mus musculus
281128 Bos taurus
291760 Rattus norvegicus
403860 Canis lupus familiaris
455353 Pan troglodytes
100065829 Equus caballus
100413004 Callithrix jacchus
100543299 Meleagris gallopavo
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