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The protein encoded by DGKQ contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. Additionally we are shipping Diacylglycerol Kinase, theta 110kDa Antibodies (75) and and many more products for this protein.
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these data demonstrate that DGKtheta; plays an important role in steroid hormone production in human adrenocortical cells
The SF1 and SREBP1 activate DGKtheta; transcription in a cAMP-dependent manner in human adrenocortical cells.
This study found that the minor alleles of GAK rs1564282 and DGKQ rs11248060 significantly increase the risk of PD in Han Chinese populations.
Data suggest that diacylglycerol kinase theta is a key mediator of bile-acid-stimulated modulation of farnesoid X receptor/mTOR complex 2/Akt signaling pathway and glucose metabolism/homoeostasis in hepatocytes.
DGKtheta; translocation and activity is regulated by the concerted activity of EGFR and PKC.
DGK-theta; directly interacts with, and is activated by, basic proteins such as histone H1 and Tau with nm affinity, consistent with a potential role for a polybasic protein or protein domain in the activation of this enzyme.
Nuclear DGK-theta co-localizes with phosphatidylinositol 4,5-bisphosphate (PIP(2)) in domains that correspond to nuclear speckles.
DGK interacts selectively with and is phosphorylated by PKCepsilon and -eta and peptide agonist-induced selective activation of PKCepsilon directly leads to DGK translocation
Data show that cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17.
Results suggest that DGKtheta; may play important physiological roles not only in the brain, but also in diverse organs and tissues during the embryonic stages.
Diacylglycerol kinase theta is regulated by magnesium and zinc.
The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction.
DAG kinase theta
, diacylglycerol kinase theta
, diglyceride kinase theta
, diacylglycerol kinase, delta (110 kDa)
, diacylglycerol kinase, theta 110kDa