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DNAJA13 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins.
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this study, which establishes mutations in DNAJB13 as a cause of PCD, unveils the key role played by DNAJB13 in the proper formation and function of ciliary and flagellar axonemes in humans
TSARG6 is specifically expressed in adult testis with a transcript of 1.8 kb, which has a role in spermatogenesis and apoptosis
Results suggest that DNAJB13 participates in spermiogenesis and the motility of mature spermatozoa.
By multi-tissue reverse transcription polymerase chain reaction, we found that Dnajb13 gene was expressed not only in the testis but also in several other ciliated cell-containing tissues like brain, lung and oviduct.
DNAJB13 might be involved in assembly and stability of axoneme during sperm flagellum development.
The interaction of DNAJB13 with SEPT4 (show SEPT4 Proteins) in vitro and its spatiotemporal association with the annulus during sperm flagellum development suggest that DNAJB13 may be involved in assembling the annulus structure.
DNAJA13 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins. For background information on the DNAJ family, see 608375.
, DnaJ (Hsp40) related, subfamily B, member 13
, DnaJ-like protein
, dnaJ homolog subfamily B member 13
, radial spoke 16 homolog A
, testis and spermatogenesis cell-related protein 6
, testis spermatocyte apoptosis-related gene 6 protein
, testis spermatogenesis apoptosis-related gene 3 protein
, testis spermatogenesis apoptosis-related gene 6 protein
, testis spermatogenesis apoptosis-related protein 6
, spermatogenesis apoptosis-related protein