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May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis (By similarity). Additionally we are shipping EF-Hand Domain Family, Member D2 Antibodies (48) and EF-Hand Domain Family, Member D2 Proteins (6) and many more products for this protein.
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Data demonstrate that EFhd2 shows unique structural and biological features as an EF-hand containing F-actin bundling protein. For F-actin bundling activity, structural stabilization of the EF-hand domains was found to occur in the presence of Ca2+. The core region of EFhd2 maintains its structure in the absence of Ca2+ ; however, changes in local conformational flexibility reduce F-actin bundling activity of EFhd2.
Phosphorylation at Ser183 of EFhd2 causes changes in the local conformational dynamics and the surface charge distribution of the actin-binding site, resulting in a re-coordination of the actin-binding sites in the dimer structure.
The results imply that EFhd2's physiological and/or pathological function could be regulated by its phosphorylation state.
EFhd2 is involved in the control of synapse development and maintenance and is linked to dementia.
Swiprosin-1 localizes to microvilli-like membrane protrusions and lamellipodia and exhibits actin-binding activity.
Swiprosin-1 is involved in regulating the accessibility of F-actin to cofilin through the clustering of F-actin and the activity of Swiprosin-1 is highly dependent on its phosphorylation status at Ser183
EFhd2 may play an important role in the pathobiology of tau-mediated neurodegeneration.
the human Shu complex (hSWS1.SWSAP1) has an evolutionarily conserved function in homologous recombination
This protein has been found differentially expressed in thalami from patients with schizophrenia.
Its predominant presence in CD8 lymphocytes suggests that swiprosin-1 may be involved in functions that are important for cytotoxic lymphocytes.
These results suggest that swiprosin-1 is a PKC-beta I/eta-inducible gene and it modulates mast cell activation through NF-kappaB-dependent pathway.
Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.
May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis (By similarity). Plays a role as negative regulator of the canonical NF-kappa-B-activating branch (By similarity). Controls spontaneous apoptosis through the regulation of BCL2L1 abundance (By similarity).
EF hand domain containing 2
, EF hand domain family, member D2
, EF-hand domain-containing protein D2
, swiprosin 1
, EF-hand domain family, member D2