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Condensing enzyme that catalyzes the synthesis of both saturated and monounsaturated very long chain fatty acids. Additionally we are shipping ELOVL Fatty Acid Elongase 1 Kits (17) and ELOVL Fatty Acid Elongase 1 Proteins (3) and many more products for this protein.
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Elongation of VLCFAs (ELOVL)1 is primarily responsible for the production of saturated VLCFAs, whereas ELOVL1, ELOVL3, and ELOVL4 redundantly participate in the synthesis of monounsaturated VLCFAs.
Elovl1 is a key determinant of epidermal ceramide chain length and is essential for permeability barrier formation.
elucidation of structure and regulation
ELOV1 promotes very long-chain fatty acid accumulation X-linked adrenoleukodystrophy and is inhibited by CoA esters of bezafibrate and gemfibrozil.
Results suggest that inhibition of atty acid elongase 1 (ELOVL1) may be an underlying mechanism by which Lorenzo's oil exerts its action.
down-regulation of ELOVL1 had a comprehensive effect on the synthesis of very long chain ceramides which possibly point to a requirement for ELOVL1 expression for full CerS2-activity.
ELOVL1 activity is regulated with the ceramide synthase CERS2, an enzyme essential for C24 sphingolipid synthesis.
The authors identify ELOVL1 (elongation of very-long-chain-fatty acids) as the single elongase catalysing the synthesis of both saturated VLCFA (C26:0) and mono-unsaturated VLCFA (C26:1).
Condensing enzyme that catalyzes the synthesis of both saturated and monounsaturated very long chain fatty acids. Exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis.
3-keto acyl-CoA synthase Elovl1
, ELOVL FA elongase 1
, ELOVL fatty acid elongase 1
, elongation of very long chain fatty acids protein 1
, elongation of very long chain fatty acids-like 1
, sequence similarity to Cig30 1
, very-long-chain 3-oxoacyl-CoA synthase 1
, 3-keto acyl-CoA synthase ELOVL1
, elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1