anti-ELOVL Fatty Acid Elongase 6 (ELOVL6) Antibodies

Fatty acid elongases (EC 6.2.1.3), such as ELOVL6, use malonyl-CoA as a 2-carbon donor in the first and rate-limiting step of fatty acid elongation (Moon et al., 2001 [PubMed 11567032]).[supplied by OMIM, Mar 2008].. Additionally we are shipping and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ELOVL6 79071 Q9H5J4
ELOVL6 170439 Q920L5
ELOVL6 171402 Q920L6
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Top anti-ELOVL Fatty Acid Elongase 6 Antibodies at antibodies-online.com

Showing 10 out of 56 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of ELOVL6 antibody (N-term) (ABIN390425) in mouse liver tissue lysates (35 µg/lane). ELOVL6 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with ELOVL6 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$385.00
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Chicken Rabbit Un-conjugated IP, WB Western blot analysis of ELOVL6 expression in Raji (A), HuvEc (B) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
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Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see Available
$181.73
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, WB ABIN6275108 staining 293 cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibod 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p), WB Human Lung (formalin-fixed, paraffin-embedded) stained with ELOVL6 antibody ABIN343916 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-ELOVL6 antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Human Lung (formalin-fixed, paraffin-embedded) stained with ELOVL6at 5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Western blot analysis of ELOVL6 in Human brain tissue lysate with ELOVL6 antibody at (A) 1 and (B) 2 µg/ml. 50 μg Log in to see 6 to 8 Days
$495.00
Details

Top referenced anti-ELOVL Fatty Acid Elongase 6 Antibodies

  1. Human Polyclonal ELOVL6 Primary Antibody for IHC (p), WB - ABIN541347 : Kanaya, Kubo, Liu, Chu, Wang, Yuan, Chen: Protective effects of white button mushroom (Agaricus bisporus) against hepatic steatosis in ovariectomized mice as a model of postmenopausal women. in PLoS ONE 2011 (PubMed)
    Show all 4 Pubmed References

More Antibodies against ELOVL Fatty Acid Elongase 6 Interaction Partners

Human ELOVL Fatty Acid Elongase 6 (ELOVL6) interaction partners

  1. Functional screening...revealed ELOVL6 as the main elongation enzyme responsible for acyl chain elongation in lung cancer squamous cell carcinoma cancer cells

  2. Ultra-high-throughput fluorescence screening followed by a RapidFire mass spectrometry assay was a suitable strategy for lead discovery against Elovl6.

  3. ). In conclusion, we found an interaction between the HLA-Cw6 and LCE genotypes on disease improvement among psoriatic patients treated with anti-TNFs.

  4. KAR regulates ELOVL6 via two modes; KAR may induce conformational changes in ELOVL6; conversion of 3-ketoacyl-CoA to 3-hydroxyacyl-CoA by KAR may facilitate release of the product from the ELOVL6-KAR complex.

  5. human liver samples from patients with Non-alcoholic steatohepatitis or Non-alcoholic steatohepatitis-related hepatocellular carcinoma showed an elevated expression of the elongase ELOVL6, which is responsible for the elongation of C16 fatty acids.

  6. The study indicated that the ELOVL6 gene polymorphism rs12504538 is associated with an increased risk of T2DM, because it causes an increase in insulin resistance.

  7. Elovl6 expression is significantly downregulated in human lung with idiopathic pulmonary fibrosis.

  8. Elovl6 expression is positively correlated with severity of hepatosteatosis and liver injury in NASH patients.

  9. study showed cystic fibrosis cells exhibit increased metabolism along metabolic pathways leading to n-7 and n-9 fatty acids compared with wild-type cells; changes are accompanied by increased expression of Delta5, Delta6 and Delta9 desaturases and elongases 5 and 6

  10. Genetic variations in the ELOVL6 gene were associated with insulin sensitivity in this population-based study.

  11. Studies suggest that inhibition of ELOVL6 could be a new therapeutic approach for the treatment of insulin resistance, diabetes, cardiovascular disease, and other metabolic diseases.

Mouse (Murine) ELOVL Fatty Acid Elongase 6 (ELOVL6) interaction partners

  1. Elovl6 is a fundamental factor linking dysregulated lipid metabolism to beta-cell dysfunction, islet inflammation, and beta-cell apoptosis in T2D, highlighting oleate as the potential culprit of beta-cell lipotoxicity.

  2. data suggest that Elovl6 plays a critical role for proper development of embryonic growth plate

  3. the synergistic action of ChREBP and SREBP-1c is necessary for the maximal induction of Elovl6 expression in the liver.

  4. These findings suggest that Elovl6-mediated changes in hepatic FA composition, especially oleic acid (C18:1n-9), control handling of hepatic cholesterol and BA, which protects against hepatotoxicity and steatohepatitis

  5. Elongation of Very Long Chain fatty acids 6 (Elovl6) is necessary for the thermogenic action of brown adipose tissue

  6. Data (including data from studies in knockout mice) confirm Elovl6 as only enzyme elongating palmitate to oleate; elongation of palmitoleate to vaccinate does not require Elovl6; deletion of Elovl6 does not prevent nonalcoholic fatty liver disease.

  7. Our findings suggest that Elovl6 could be involved in insulin secretory capacity per beta-cell and diabetes.

  8. Elovl6 deficiency results in a change in fatty acid composition, induction of apoptosis, TGF-beta1 expression and reactive oxygen species generation.

  9. Elovl6 is a critical modulator for atherogenic high-fat diet-induced inflammation, oxidative stress, and fibrosis in the liver.

  10. REVIEW: fatty acid metabolism and lipotoxicity; discussion of the role of Elovl6 in newly recognized aspects of metabolic regulation

  11. Elovl6 in macrophages may contribute to foam cell formation and progression of atherosclerosis.

  12. data indicate this elongase is a lipogenic enzyme regulated by SREBP-1, playing an important role in de novo synthesis of long-chain saturated and monosaturated fatty acids in conjunction with fatty acid synthase and stearoyl-CoA desaturase.

  13. These data demonstrated that Elovl-6 is regulated directly and primarily by SREBP-1c.

  14. Change in composition of fatty acids due to Elovl-6 is the dicisive factor for gene expression of energy metabolism and life-style associated disorders. (review)

  15. Studies suggest that inhibition of ELOVL6 could be a new therapeutic approach for the treatment of insulin resistance, diabetes, cardiovascular disease, and other metabolic diseases.

Cow (Bovine) ELOVL Fatty Acid Elongase 6 (ELOVL6) interaction partners

  1. ELOVL6 is expressed ubiquitously in mammary epithelial cells and is activated by SREBF1 and SP1, via two binding sites present in the ELOVL6 promoter region between -130 bp to -41bp.

Pig (Porcine) ELOVL Fatty Acid Elongase 6 (ELOVL6) interaction partners

  1. fatty acid elongase 6 gene region is associated with backfat fatty acid composition.

  2. the present study described cloning and expression of porcine ELOVL6 gene in HEK293T cells. The data demonstrated that human cell, a heterologous system, supported the expression of porcine Elongase6.

  3. ELOVL6:c.-394G > A polymorphism as the causal mutation for the QTL on pig chromosome 8 that affects fatty acid composition in pigs.

  4. ELOVL6 as a potential causal gene for the QTL and for controlling the overall balance of fatty acid composition in pigs

ELOVL Fatty Acid Elongase 6 (ELOVL6) Antigen Profile

Protein Summary

Fatty acid elongases (EC 6.2.1.3), such as ELOVL6, use malonyl-CoA as a 2-carbon donor in the first and rate-limiting step of fatty acid elongation (Moon et al., 2001

Gene names and symbols associated with ELOVL6

  • ELOVL fatty acid elongase 6 (ELOVL6) antibody
  • ELOVL family member 6, elongation of long chain fatty acids (yeast) (Elovl6) antibody
  • ELOVL fatty acid elongase 6 (Elovl6) antibody
  • ELOVL fatty acid elongase 6 (elovl6) antibody
  • elongation of very long chain fatty acids protein 6 (Tsp_06132) antibody
  • elongation of very long chain fatty acids protein 6-like (LOC108710167) antibody
  • C77826 antibody
  • cb618 antibody
  • elovl6 antibody
  • FACE antibody
  • FAE antibody
  • lce antibody
  • Lce2 antibody
  • rELO2 antibody
  • zgc:73089 antibody

Protein level used designations for ELOVL6

3-keto acyl-CoA synthase ELOVL6 , ELOVL FA elongase 6 , ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast) , elongation of very long chain fatty acids protein 6 , fatty acid elongase 2 , fatty acyl-CoA elongase , hELO2 , long-chain fatty-acyl elongase , very-long-chain 3-oxoacyl-CoA synthase 6 , 3-keto acyl-CoA synthase Elovl6 , ELOVL fatty acid elongase 6 , long chain fatty acid elongase , long chain fatty acyl elongase , myelin-associated SUR4 protein , ELOVL family member 6, elongation of long chain fatty acids , 3-keto acyl-CoA synthase elovl6 , elongation of very long chain fatty acids family member protein 6 , elongation of very long chain fatty acids protein 6-like

GENE ID SPECIES
79071 Homo sapiens
170439 Mus musculus
171402 Rattus norvegicus
317738 Danio rerio
428772 Gallus gallus
533333 Bos taurus
10911520 Trichinella spiralis
100528278 Ictalurus punctatus
100312970 Sus scrofa
100718388 Cavia porcellus
108710167 Xenopus laevis
487900 Canis lupus familiaris
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