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Fatty acid elongases (EC 184.108.40.206), such as ELOVL6, use malonyl-CoA as a 2-carbon donor in the first and rate-limiting step of fatty acid elongation (Moon et al., 2001 [PubMed 11567032]).[supplied by OMIM, Mar 2008].. Additionally we are shipping and many more products for this protein.
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Human Polyclonal ELOVL6 Primary Antibody for IHC (p), WB - ABIN541347
Kanaya, Kubo, Liu, Chu, Wang, Yuan, Chen: Protective effects of white button mushroom (Agaricus bisporus) against hepatic steatosis in ovariectomized mice as a model of postmenopausal women. in PLoS ONE 2011
Show all 4 Pubmed References
Functional screening...revealed ELOVL6 as the main elongation enzyme responsible for acyl chain elongation in lung cancer squamous cell carcinoma cancer cells
Ultra-high-throughput fluorescence screening followed by a RapidFire mass spectrometry assay was a suitable strategy for lead discovery against Elovl6.
). In conclusion, we found an interaction between the HLA-Cw6 and LCE genotypes on disease improvement among psoriatic patients treated with anti-TNFs.
KAR regulates ELOVL6 via two modes; KAR may induce conformational changes in ELOVL6; conversion of 3-ketoacyl-CoA to 3-hydroxyacyl-CoA by KAR may facilitate release of the product from the ELOVL6-KAR complex.
human liver samples from patients with Non-alcoholic steatohepatitis or Non-alcoholic steatohepatitis-related hepatocellular carcinoma showed an elevated expression of the elongase ELOVL6, which is responsible for the elongation of C16 fatty acids.
The study indicated that the ELOVL6 gene polymorphism rs12504538 is associated with an increased risk of T2DM, because it causes an increase in insulin resistance.
Elovl6 expression is significantly downregulated in human lung with idiopathic pulmonary fibrosis.
Elovl6 expression is positively correlated with severity of hepatosteatosis and liver injury in NASH patients.
study showed cystic fibrosis cells exhibit increased metabolism along metabolic pathways leading to n-7 and n-9 fatty acids compared with wild-type cells; changes are accompanied by increased expression of Delta5, Delta6 and Delta9 desaturases and elongases 5 and 6
Genetic variations in the ELOVL6 gene were associated with insulin sensitivity in this population-based study.
Studies suggest that inhibition of ELOVL6 could be a new therapeutic approach for the treatment of insulin resistance, diabetes, cardiovascular disease, and other metabolic diseases.
Elovl6 is a fundamental factor linking dysregulated lipid metabolism to beta-cell dysfunction, islet inflammation, and beta-cell apoptosis in T2D, highlighting oleate as the potential culprit of beta-cell lipotoxicity.
data suggest that Elovl6 plays a critical role for proper development of embryonic growth plate
the synergistic action of ChREBP and SREBP-1c is necessary for the maximal induction of Elovl6 expression in the liver.
These findings suggest that Elovl6-mediated changes in hepatic FA composition, especially oleic acid (C18:1n-9), control handling of hepatic cholesterol and BA, which protects against hepatotoxicity and steatohepatitis
Elongation of Very Long Chain fatty acids 6 (Elovl6) is necessary for the thermogenic action of brown adipose tissue
Data (including data from studies in knockout mice) confirm Elovl6 as only enzyme elongating palmitate to oleate; elongation of palmitoleate to vaccinate does not require Elovl6; deletion of Elovl6 does not prevent nonalcoholic fatty liver disease.
Our findings suggest that Elovl6 could be involved in insulin secretory capacity per beta-cell and diabetes.
Elovl6 deficiency results in a change in fatty acid composition, induction of apoptosis, TGF-beta1 expression and reactive oxygen species generation.
Elovl6 is a critical modulator for atherogenic high-fat diet-induced inflammation, oxidative stress, and fibrosis in the liver.
REVIEW: fatty acid metabolism and lipotoxicity; discussion of the role of Elovl6 in newly recognized aspects of metabolic regulation
Elovl6 in macrophages may contribute to foam cell formation and progression of atherosclerosis.
data indicate this elongase is a lipogenic enzyme regulated by SREBP-1, playing an important role in de novo synthesis of long-chain saturated and monosaturated fatty acids in conjunction with fatty acid synthase and stearoyl-CoA desaturase.
These data demonstrated that Elovl-6 is regulated directly and primarily by SREBP-1c.
Change in composition of fatty acids due to Elovl-6 is the dicisive factor for gene expression of energy metabolism and life-style associated disorders. (review)
ELOVL6 is expressed ubiquitously in mammary epithelial cells and is activated by SREBF1 and SP1, via two binding sites present in the ELOVL6 promoter region between -130 bp to -41bp.
the present study described cloning and expression of porcine ELOVL6 gene in HEK293T cells. The data demonstrated that human cell, a heterologous system, supported the expression of porcine Elongase6.
ELOVL6:c.-394G > A polymorphism as the causal mutation for the QTL on pig chromosome 8 that affects fatty acid composition in pigs.
ELOVL6 as a potential causal gene for the QTL and for controlling the overall balance of fatty acid composition in pigs
Fatty acid elongases (EC 220.127.116.11), such as ELOVL6, use malonyl-CoA as a 2-carbon donor in the first and rate-limiting step of fatty acid elongation (Moon et al., 2001
3-keto acyl-CoA synthase ELOVL6
, ELOVL FA elongase 6
, ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)
, elongation of very long chain fatty acids protein 6
, fatty acid elongase 2
, fatty acyl-CoA elongase
, long-chain fatty-acyl elongase
, very-long-chain 3-oxoacyl-CoA synthase 6
, 3-keto acyl-CoA synthase Elovl6
, ELOVL fatty acid elongase 6
, long chain fatty acid elongase
, long chain fatty acyl elongase
, myelin-associated SUR4 protein
, ELOVL family member 6, elongation of long chain fatty acids
, 3-keto acyl-CoA synthase elovl6
, elongation of very long chain fatty acids family member protein 6
, elongation of very long chain fatty acids protein 6-like