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Down-regulation of EBF2 (and EBF1) genes leads to severe impairment of myelin formation in Schwann cells.
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we show that SIX1 binds to adipogenic and brown marker genes and interacts with C/EBPa, C/EBPb and EBF2, suggesting their functional cooperation during adipogenesis.
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Data indicate that Contactin-1 expression is dependent upon EBF factors; Cntn1 gene belongs to the expanding regulatory cascade driven by these transcriptional regulators so that changes in its activation may contribute to the Ebf2 null mutant phenotype
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Study identified Ebf2 as a novel and important regulator selectively required for midbrain periaqueductal gray matter dopamine neuron development
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Results indicate that early B cell factor 2 (Ebf2) specifically marks and regulates the molecular profile of brown preadipose cells.
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Blnc1 forms a ribonucleoprotein complex with transcription factor EBF2 to stimulate the thermogenic gene program. Further, Blnc1 itself is a target of EBF2, thereby forming a feedforward regulatory loop to drive adipogenesis toward thermogenic phenotype.
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Ebf2 protein recruits Pparg to brown fat-selective gene targets, including Prdm16, to determine brown identity.
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These findings indicate that Ebf2 is important for the development and maintenance of normal Purkinje cell discharge properties
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Ebf2 and Ebf3, singly or together, control the migration of Cajal-Retzius cells arising in the cortical hem. These findings provide evidence that Ebfs directly regulate Cajal-Retzius cell development
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Ebf2 is important for early cortical neurogenesis and regulates the generation of Cajal-Retzius neurons in the developing cerebral cortex.
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Ebf2 is implicated in peripheral nerve development as a potential candidate gene for peripheral nerve disorders.
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This study demonistrated that reveal that O/E3-null mouse is a different model of narcolepsy where the orexinergic circuitry is distorted. Evidence proves that many neuronal subpopulations are altered in O/E3-null mice.
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Ebf2 acts as a transcriptional determinant of an osteoblastic niche that regulates the maintenance of hematopoietic progenitors, in part by modulating Wnt signaling
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Data show that Ebf2-null mice reveal a novel genetic cause of hypogonadotropic hypogonadism and peripheral neuropathy in the mouse, disclosing an important role for Ebf2 in neuronal migration and nerve development.
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Results suggest that Ebf2 is required for the establishment of a proper cerebellar cortical map.
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Reduction of Ebf1 and Ebf2 proteins by specific short hairpin RNA blocks differentiation of 3T3-L1 cells, suggesting a critical role for these factors and the absence of functional redundancy between members of this family.
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Ebf2 regulates the expression of genes associated with the zebrin II+ Purkinje cell phenotype