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EGR3 encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. Additionally we are shipping EGR3 Antibodies (65) and EGR3 Kits (30) and many more products for this protein.
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KSRP (show KHSRP Proteins) decreased EGR3 mRNA stability in an ARE-independent manner.
miR (show MLXIP Proteins)-718 acts as a tumor suppressive microRNA in hepatocellular carcinoma via regulating the expression of EGR3, which may provide a new diagnostic marker and treatment target for HCC (show FAM126A Proteins)
Egr2 (show EGR2 Proteins) and Egr3 have emerged as regulatory molecules that suppress excessive immune responses. Mice deficient for Egr2 (show EGR2 Proteins) and Egr3 develop a lupus-like disease with dysregulated activation of effector T cells. Egr2 (show EGR2 Proteins) and Egr3 confer suppressive activity to CD4 (show CD4 Proteins)(+) T cells and regulate the production of inhibitory cytokines such as IL-10 (show IL10 Proteins) and TGF-beta1 (show TGFB1 Proteins).
EGR3 contributes to cell growth inhibition via upregulation of FasL (show FASL Proteins) in Hepatocellular carcinoma.
In the PPI network, genes may be involved in Down syndrome (DS) by interacting with others, including nuclear receptor subfamily 4 group A member 2 (NR4A2 (show NR4A2 Proteins))early growth response (EGR)2 (show EGR2 Proteins) and NR4A2EGR3. Therefore, RUNX1 (show RUNX1 Proteins), NR4A2 (show NR4A2 Proteins), EGR2 (show EGR2 Proteins), EGR3 and ID4 (show ID4 Proteins) may be key genes associated with the pathogenesis of DS.
These findings support previously reported associations between EGR3 and schizophrenia.
EGR3 promotes excessive production of IL6 (show IL6 Proteins) and IL8 (show IL8 Proteins) observed during the progression of prostate cancer.
Data shows association of Egr3 genetic polymorphisms and coronary artery disease in the Uygur and Han of China
Genetic variation in EGR3 may affect prefrontal function through neurodevelopment
These results provide the first evidence that Egr-3, is up-regulated in scleroderma and is necessary and sufficient for profibrotic responses.
Egr2 (show EGR2 Proteins) and Egr3 expressed in T cells cooperatively prevent humoral immune responses by supporting TGF-beta3 (show TGFB3 Proteins) secretion.
Study demonstrates in mice that explored novel spatial environments, the involvement of Egr3 in regulating the late protein-dependent phase of Arc (show NOL3 Proteins) expression in the dentate gyrus.
Egr2 (show EGR2 Proteins) and 3 are upstream regulators of effector CD4 (show CD4 Proteins) and CD8 (show CD8A Proteins) T cells that are essential for optimal responses with limited immunopathology.
Egr2 and 3 are antagonists of T-bet function in effector T cells and are important for the control of inflammatory responses of T cells.
Egr3 knockout mice, lacking muscle spindles, but not Golgi tendon organs, displayed a less severe prepubertal scoliosis.
Egr3 is involved in myoblast proliferation by interaction with survival signaling.
Study showed that acute stress activates 5-HT2AR expression in the mouse cortex and this activation requires the immediate early (show JUN Proteins) gene Egr3
demonstrate a novel function of EGR2 (show EGR2 Proteins)/3 that is important for Tfh cell development and Tfh cell-mediated B cell immune responses
Gene expression profiling and further functional validation revealed that Egr3 was a strong limiting factor for the proliferative potential of hematopoietic stem cells in leukemia.
Egr3 overexpression in medium spiny neurons subtypes oppositely mediates behavioral responses to cocaine. Egr3 regulates cocaine-associated genes transcriptionally
Expression of both the egr1 (show EGR1 Proteins) and egr3 mRNAs were observed in the telencephalon, hypothalamus, and optic tectum, however, the positions at which the genes were expressed were different.
This gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controling biological rhythm. It may also play a role in a wide variety of processes including muscle development, lymphocyte development, endothelial cell growth and migration, and neuronal development. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
early growth response protein 3
, zinc finger protein pilot
, early growth response 3
, early growth response protein 3-like