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EMR1 encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus.
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EMR1 expression is significantly upregulated in human masticatory mucosa during wound healing
Additional transcription changes likely associated with Th2-like eosinophilic inflammation were prominent and included increased EMR1&3.
EMR1 expression is restricted to mature blood and tissue eosinophils. Targeting of eosinophils with afucosylated anti-EMR1 antibody shows promise as a treatment for eosinophilic disorders.
CD11b (show ITGAM ELISA Kits) and F4/80 appear to participate in conjunctival eosinophil infiltration in allergic conjunctivitis.
These results demonstrate that MafB is essential for podocyte differentiation, renal tubule survival, and F4/80 maturation in a distinct subpopulation of nonadherent mature macrophages.
Expression of CCR2 and F4/80 increased after ethanol feeding in WT mice, but such increase was less evident in H-STAT3KO mice.
c-Maf (show MAF ELISA Kits) is required for the F4/80 expression in macrophages in vivo.
Flow analysis indicated little overlap between the F4/80 and CSF-1R (show CSF1R ELISA Kits)-positive populations in peritoneal macrophage.
This gene encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
EGF-like module-containing mucin-like hormone receptor-like 1
, EGF-like module containing, mucin-like, hormone receptor-like sequence 1
, egf-like module containing, mucin-like, hormone receptor-like 1
, egf-like module containing, mucin-like, hormone receptor-like sequence 1
, EGF-like module-containing mucin-like hormone receptor-like 1-like
, EGF-like module receptor 1
, EMR1 hormone receptor
, cell surface glycoprotein EMR1
, cell surface glycoprotein F4/80
, lymphocyte antigen 71