ElaC Homolog 2 (E. Coli) Proteins (ELAC2)

The protein encoded by ELAC2 has a C-terminal domain with tRNA 3' processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. Additionally we are shipping ElaC Homolog 2 (E. Coli) Antibodies (52) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ELAC2 68626 Q80Y81
ELAC2 60528 Q9BQ52
Rat ELAC2 ELAC2 282826 Q8CGS5
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Top ElaC Homolog 2 (E. Coli) Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,984.89
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,984.89
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
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ELAC2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
, ,

More Proteins for ElaC Homolog 2 (E. Coli) (ELAC2) Interaction Partners

Human ElaC Homolog 2 (E. Coli) (ELAC2) interaction partners

  1. ELAC2 rs11545302 polymorphism was associated with PSA > 20 and rs4792311 was associated with TNM > 2.

  2. A homozygous splicing mutation in ELAC2 suggests phenotypic variability including intellectual disability with minimal cardiac involvement

  3. ELAC2 mutations cause a mitochondrial RNA processing defect associated with hypertrophic cardiomyopathy.

  4. results indicate that ELAC2 functions as a tRNase Z in human mitochondria and suggest that mt-tRNase Z preferentially cleaves molecules already processed by the proteinaceous mtRNase P

  5. ELAC2 and PTCD1 affect the 3' end processing of tRNAs.

  6. analysis of dual nuclear/mitochondrial targeting of the ELAC2 gene product by alternative translation initiation

  7. Data describe polymorphisms in the HPC/ELAC-2 and alpha 1-antitrypsin (show SERPINA1 Proteins) genes that correlate with human diseases in an Indian population.

  8. ELAC2 polymorphisms are associated with prostate cancer.

  9. Our findings corroborate the involvement of ELAC2, MSR1 (show MSR1 Proteins), and RNASEL (show RNASEL Proteins) in the etiology of prostate cancer even in individuals without a family history.

  10. variation in the putative prostate cancer susceptibility gene ELAC2 contributes to the elevated risk of prostate cancer in Afro-Caribbean males from Tobago

ElaC Homolog 2 (E. Coli) (ELAC2) Protein Profile

Protein Summary

The protein encoded by this gene has a C-terminal domain with tRNA 3' processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with ELAC2

  • elaC ribonuclease Z 2 (ELAC2)
  • elaC ribonuclease Z 2 (Elac2)
  • 1110017O07Rik protein
  • D11Wsu80e protein
  • ELC2 protein
  • HPC2 protein

Protein level used designations for ELAC2

RNase Z 2 , elaC homolog protein 2 , ribonuclease Z 2 , tRNA 3 endonuclease 2 , tRNase Z 2 , tRNase Z(L) , zinc phosphodiesterase ELAC protein 2 , elaC homolog 2 , heredity prostate cancer protein 2 , putative prostate cancer susceptibility protein HPC2/ELAC2 , tRNase Z (long form)

GENE ID SPECIES
489511 Canis lupus familiaris
68626 Mus musculus
450109 Pan troglodytes
60528 Homo sapiens
282826 Rattus norvegicus
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