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The longest protein isoform encoded by EFS contains an SH3 domain, which is known to be important in intracellular signal transduction.
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EFS and CASS4 (show CASS4 Antibodies) protein function in the context of the larger CAS (show CSE1L Antibodies) family group. [Review]
we suggest that EFS should be considered as a novel tumor suppressor gene in prostate cancer.
Analysis of 16 Uveal melanoma showed full methylation of the EFS CpG island in 8 (50%), no methylation in 5(31%)and partial methylation in 3 (19%)tumors. Kaplan-Meier analysis revealed higher risk of metastatic progression for tumors with EFS methylation.
Sin (show POLR3E Antibodies)-deficient mice exhibit exaggerated immune responses characterized by enhanced cytokine secretion and T-cell-dependent antibody production.
The longest protein isoform encoded by this gene contains an SH3 domain, which is known to be important in intracellular signal transduction. The protein encoded by a similiar gene in mice was shown to bind to SH3 domains of protein-tyrosine kinases. The function of this gene is unknown. Three alternatively spliced variants encoding different isoforms have been described for this gene.
Cas scaffolding protein family member 3
, signal transduction protein (SH3 containing)
, SRC-interacting protein
, signal-integrating protein