Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) ELISA Kits

The protein encoded by ERAP1 is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. Additionally we are shipping ERAP1 Antibodies (70) and ERAP1 Proteins (7) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
ERAP1 51752 Q9NZ08
ERAP1 80898 Q9EQH2
ERAP1 80897 Q9JJ22
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Top ERAP1 ELISA Kits at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.039 ng/mL 0.156-10 ng/mL Typical standard curve 96 Tests Log in to see 15 to 18 Days
$910.56
Details
Mouse
  96 Tests Log in to see 15 to 18 Days
$875.60
Details
Rat
  96 Tests Log in to see 15 to 18 Days
$875.60
Details

More ELISA Kits for ERAP1 Interaction Partners

Human Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) interaction partners

  1. Data demonstrate that HCMV miR (show MLXIP ELISA Kits)-UL112-5p targets ERAP1, thereby inhibiting the processing and presentation of the HCMV pp65495-503 peptide to specific CTLs.

  2. these results present the first direct evidence that human disease-associated ERAP1 variants can greatly alter survival, as well as antigen presentation, T-cell repertoire and NK cell responses in vivo in mice

  3. The ERAP1 association with ankylosing spondylitis is predominantly attributable to common ERAP1 haplotypes and haplotype combinations.

  4. these study reports an association of the ERAP1 SNP rs30187 with the HLA-C*07 allele in inflammatory bowel disease in the Spanish population

  5. Study suggests that ERAP1 rs27044 polymorphism may be related to ankylosing spondylitis susceptibility in Chinese Han population.

  6. Segregating according to HLAB27 status did not alter the lack of association. rs30187 SNP in ERAP1 does not confer risk of developing ERA or AS in the Asian Indian population.

  7. ERAP1 and ERAP2 have significant and distinct effects on the HLA-B*27 peptidome, suggesting that both enzymes largely act as separate entities in vivo. This may explain their different patterns of association with AS.

  8. This review focuses on the ambivalent role of HLA-B27 in autoimmunity and viral protection correlating its functions to the quantitative and qualitative effects of ERAP1 and ERAP2 (show ERAP2 ELISA Kits) polymorphisms on their enzymatic activity.

  9. The ERAP1 gene polymorphism might be a risk factor in the pathogenesis of ankylosing spondylitis and inflammatory bowel disease. In contrast, IL-23R (show IL23R ELISA Kits) gene polymorphisms may serve a protective role in ankylosing spondylitis and inflammatory bowel disease.

  10. Our results suggest that normal levels of ERAP1 reduce the accumulation of aberrant and disulfide-linked forms of HLA-B27 in monocytes, and thus help to maintain the integrity of cell surface HLA-B27 complexes.

Mouse (Murine) Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) interaction partners

  1. we have shown that the loss of ERAAP leads to shifts in the nature and lengths of peptides presented by MHC I molecules on the cell surface

  2. results suggest that several aminopeptidases play important roles in the maximum synthesis of NO in activated macrophages in a substrate peptide-dependent manner and ERAP1 is one of the aminopeptidases involved in the NO synthesis

  3. Data show that endoplasmic reticulum protein 44 (ERp44 (show ERP44 ELISA Kits)) forms a mixed disulfide bond with aminopeptidase (show ANPEP ELISA Kits) ERAP1 and controls the release of ERAP1 in a redox-dependent manner to control blood pressure.

  4. This study clarifies ERAP1's role in shaping immunodominance through creation and destruction of peptides in vivo and demonstrates the functional significance of ERAP1 in modulating T-cell killing based upon this role.

  5. These results suggest that secretion of ERAP1 is mediated by toll (show TLR4 ELISA Kits)-like receptors via induction of intermediate cytokines

  6. ERAP1 directly alters peptide binding and presentation by HLA-B27, thus demonstrating a potential pathogenic mechanism in ankylosing spondylitis.

  7. Absence of Tpn or ERAAP independently altered the peptide repertoire by causing loss as well as gain of new pMHC I. ERAAP defined the characteristic amino termini of canonical MHC I peptides.

  8. MHC class Ib-restricted cytolytic effector cells specifically eliminated ERAAP-deficient cells in vitro and in vivo.

  9. endoplasmic reticulum aminopeptidase 1 is involved in the activation of macrophages induced by lipopolysaccharide and interferon-gamma (show IFNG ELISA Kits)

  10. ERAAP silencing results in MHC-I peptide-loading defects eliciting rejection of the murine T-cell lymphoma RMA in syngeneic mice

ERAP1 Antigen Profile

Antigen Summary

The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.

Gene names and symbols associated with ERAP1

  • endoplasmic reticulum aminopeptidase 1 (ERAP1) antibody
  • endoplasmic reticulum aminopeptidase 1 (erap1) antibody
  • endoplasmic reticulum aminopeptidase 1b (erap1b) antibody
  • endoplasmic reticulum aminopeptidase 1 (Erap1) antibody
  • A-LAP antibody
  • ALAP antibody
  • Appils antibody
  • ARTS-1 antibody
  • Arts1 antibody
  • DKFZp469C044 antibody
  • ERAAP antibody
  • ERAAP1 antibody
  • MGC166160 antibody
  • PILS-AP antibody
  • PILSA antibody
  • PILSAP antibody

Protein level used designations for ERAP1

endoplasmic reticulum aminopeptidase 1 , endoplasmic reticulum aminopeptidase 1-like , type 1 tumor necrosis factor receptor shedding aminopeptidase regulator , adipocyte-derived leucine aminopeptidase , aminopeptidase PILS , aminopeptidase regulator of TNFR1 shedding , endoplasmic reticulum aminopeptidase associated with antigen processing , puromycin-insensitive leucyl-specific aminopeptidase , A-LAP , ARTS-1 , PILS-AP , VEGF-induced aminopeptidase , ER-aminopeptidase 1 , leucyl-specific aminopeptidase PILS

GENE ID SPECIES
427122 Gallus gallus
488898 Canis lupus familiaris
514617 Bos taurus
100010465 Monodelphis domestica
100173512 Pongo abelii
100391536 Callithrix jacchus
100477111 Ailuropoda melanoleuca
100496768 Xenopus (Silurana) tropicalis
100565356 Anolis carolinensis
100602026 Nomascus leucogenys
393175 Danio rerio
471835 Pan troglodytes
699996 Macaca mulatta
100352256 Oryctolagus cuniculus
51752 Homo sapiens
80898 Mus musculus
80897 Rattus norvegicus
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