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Transcriptional activator that binds to the enhancer of the adenovirus E1A gene\; the core-binding sequence is 5'[AC]GGA[AT]GT-3'..
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Many of the ewing sarcoma family of tumors with negative NKX2.2 immunoreactivity were in bone. Strong/moderate ETV4 nuclear expression was detected in two small round cell tumors
four oncogenic ETS (show ETS1 ELISA Kits) (ERG (show ERG ELISA Kits), ETV1 (show ETV1 ELISA Kits), ETV4, and ETV5), and no other ETS (show ETS1 ELISA Kits), interact with the Ewing's sarcoma breakpoint protein, EWS (show EWSR1 ELISA Kits).
FOS strongly binds to the same MED25 (show MED9 ELISA Kits) site as ETV4 activation domain and JUN (show JUN ELISA Kits) interacts with the other two MED25 (show MED9 ELISA Kits) sites.
Our results indicate that assessing AP1 (show FOSB ELISA Kits) and PEA3 transcription factor status might be a good indicator of OAC status. However, we could not detect any associations with disease stage or patient treatment regime. This suggests that the PEA3-AP1 (show FOSB ELISA Kits) regulatory module more likely contributes more generally to the cancer phenotype. In keeping with this observation, depletion of ETV1 (show ETV1 ELISA Kits) and/or ETV4 causes an OAC cell growth defect
ETV4 overexpression is associated with lung cancer metastasis.
Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETV1, ETV4 and ETV5.
The data provide the molecular details of ETV4-mediated NANOG gene expression.
the prostate cancer-related oncogenic E26 transformation-specific (ETS) transcription factors, ETV1, ETV4, and ETV5, were required for TAZ gene transcription in PC3 prostate cancer cells
NCOA2ETV4 protein would contain the helixloophelix, PAS_9 and PAS_11, CITED domains, the SRC1 (show SRC ELISA Kits) domain of NCOA2 and the ETS (show ETS1 ELISA Kits) DNAbinding domain of ETV4.
PEA3-subgroup transcription factors are key players of the Met signaling integration involved in regulation of migration and invasiveness of tumor cells.
The E26 transformation-specific transcription factor, ETV4, which is induced by fibroblast growth factor signalling and acts as a repressor of ZRS activity, interacts with the histone deacetylase (show HDAC1 ELISA Kits) HDAC2 (show HDAC2 ELISA Kits) and ensures that the poised ZRS remains transcriptionally inactive.
Our results will help understand the mechanism of ETV4 overexpression in CRC (show SCRIB ELISA Kits) patients and provide a clue to search new therapeutic target to treat the related tumors in clinical practice.
ETS-related transcription factors ETV4 and ETV5 are involved in proliferation and induction of differentiation-associated genes in embryonic stem (ES) cells.
paracrine signaling via fibroblast growth factor 2 (Fgf2 (show FGF2 ELISA Kits)) and Mapk (show MAPK1 ELISA Kits) between these diverged tumor subclones causes enhanced expression of the Pea3 transcription factor, resulting in metastatic dissemination of the neuroendocrine tumor subclones.
Study hypothesized that PEA3 might play an essential role in the activation of the FAK (show PTK2 ELISA Kits) gene during tumor metastasis.
Study reveals molecular insight into how the Ets (show ETS1 ELISA Kits) family transcription factor Pea3 favors EMT (show ITK ELISA Kits) and contributes to tumorigenesis via a negative regulatory loop with Cyclin D2 (show CCND2 ELISA Kits), a new Pea3 target gene.
oncogenic Etv4 promotes prostate cancer metastasis in response to coactivation of PI3-kinase and Ras signaling pathways in a genetically engineered model of highly penetrant, metastatic prostate cancer
PEA3-null fibroblasts exhibit impaired c-src activation and motility defects.
Smad2 (show SMAD2 ELISA Kits) and PEA3 regulate RGC-32 (show C13orf15 ELISA Kits) transcription which is essential for smooth muscle cell differentiation from neural crest cells.
study provides evidence for a protumorigenic role of PEA3 factors in breast neoplasia, and supports targeting the PEA3 transcription factor family in breast cancer
etv5a and etv4 have roles in mediating epithelial cell fate during zebrafish kidney development
Pea3 and erm are required for zebrafish pronephrogenesis and can functionally complement each other, and the wt1a gene may be one of their downstream targets.
Overlapping functions of pea3 ETS (show ETS1 ELISA Kits) transcription factors in FGF signaling during zebrafish development are reported.
Transcriptional activator that binds to the enhancer of the adenovirus E1A gene\; the core-binding sequence is 5'GT-3'.
ETS translocation variant 4
, EWS protein/E1A enhancer binding protein chimera
, adenovirus E1A enhancer-binding protein
, ets variant gene 4 (E1A enhancer-binding protein, E1AF)
, polyomavirus enhancer activator 3 homolog
, ets variant gene 4 (E1A enhancer binding protein, E1AF)
, polyomavirus enhancer activator-3
, ets domain protein
, ETS variant protein 4
, POLYOMAVIRUS ENHANCER ACTIVATOR 3 (PEA3 PROTEIN) (ETS TRANSLOCATION VARIANT 4)
, ETS translocation variant 4-like
, ETS domain-containing transcription factor PEA3
, ETS-domain transcription factor pea3