anti-Eukaryotic Translation Initiation Factor 4 gamma 2 (EIF4G2) Antibodies

Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. Additionally we are shipping EIF4G2 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
EIF4G2 1982 P78344
EIF4G2 361628  
EIF4G2 13690 Q62448
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Top anti-EIF4G2 Antibodies at antibodies-online.com

Showing 10 out of 109 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-EIF4G2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  721_B cell lysate EIF4G2 is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells Rabbit Anti-EIF4G2 Antibody   Formalin Fixed Paraffin Embedded Tissue: Human Liver Tissue Observed Staining: Cytoplasm in hepatocytes Primary Antibody Concentration: 1:100 Other Working Concentrations: N/A Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 - 2.0 sec 100 μL 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-EIF4G2 Antibody Titration:  0.2-1 ug/ml  Positive Control:  HepG2 cell lysate Sample Type: 1. IAH30 cells (0.5x106 cells loaded)2. DF-1 cells (0.5x106 cells loaded)Primary Dilution: 1:1000 Secondary Antibody: Goat anti-rabbit IgG (whole molecule) peroxidase Secondary Dilution:1:10,000 Image Submitted By: Yongxiu YaoInstitute for Animal Health 100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB IHC-P Image Immunohistochemical analysis of paraffin-embedded human skeletal muscle , using DAP5, antibody(10 μg/ml). WB Image Sample(30 μg of whole cell lysate) A:A431, 7.5% SDS PAGE antibody diluted at 1:1000 100 μL 3 to 4 Days
$466.18
Details
Human Rabbit Un-conjugated IHC (p), WB IHC-P Image DAP5 antibody [C2C3], C-term detects DAP5 protein at cytosol on mouse kidney by immunohistochemical analysis. Sample: Paraffin-embedded mouse kidney. DAP5 antibody [C2C3], C-term , dilution: 1:500. WB Image Sample (30 ug of whole cell lysate) A: Hela B: Hep G2 , 7.5% SDS PAGE antibody diluted at 1:1000 100 μL 3 to 4 Days
$466.18
Details
Cow Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of EIF4G2 staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of EIF4G2 staining in human liver cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IHC, WB 100 μL 11 to 13 Days
$366.77
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from A549 cells, using EIF4G2 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, IF, IHC, WB Western Blot (WB) analysis of specific cells using DAP-5 Polyclonal Antibody. 100 μL Available
$363.46
Details
Human Mouse Un-conjugated IHC (p), WB 50 μg 6 to 8 Days
$495.00
Details
Human Mouse Un-conjugated IHC, IHC (p), WB Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with EIF4G2 antibody ABIN295986 at 10 ug/ml followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. Anti-EIF4G2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. 50 μg 11 to 14 Days
$484.00
Details

Top referenced anti-EIF4G2 Antibodies

  1. Human Monoclonal EIF4G2 Primary Antibody for FACS, WB - ABIN265943 : Levy-Strumpf, Deiss, Berissi, Kimchi: DAP-5, a novel homolog of eukaryotic translation initiation factor 4G isolated as a putative modulator of gamma interferon-induced programmed cell death. in Molecular and cellular biology 1997 (PubMed)
    Show all 6 Pubmed References

  2. Human Monoclonal EIF4G2 Primary Antibody for IHC (p), ELISA - ABIN560721 : Katsogiannou, Andrieu, Baylot, Baudot, Dusetti, Gayet, Finetti, Garrido, Birnbaum, Bertucci, Brun, Rocchi: The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. in Molecular & cellular proteomics : MCP 2014 (PubMed)

More Antibodies against EIF4G2 Interaction Partners

Human Eukaryotic Translation Initiation Factor 4 gamma 2 (EIF4G2) interaction partners

  1. the present results suggested that circEIF4G2 may be a novel oncogene in CC. Furthermore, circEIF4G2 may promote CC cell growth and migration by sponging miR-218, thus increasing the expression levels of HOXA1.

  2. The percentage at the S-stage was decreased in the miR-379 mimics and EIF4G2 shRNA groups.

  3. DAP5 knockdown from human ESCs (hESCs) resulted in persistence of pluripotent gene expression, delayed induction of differentiation-associated genes in different cell lineages, and defective embryoid body formation

  4. Data show that microRNA miR-379 potentiated lung cancer (LCa) chemosensitivity via modulation of cisplatin (CDDP)-induced apoptosis by directly targeting the eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) 3' UTR.

  5. These results indicate that miR-139 is capable of inhibiting chondrocyte proliferation and migration, thus being a possible therapeutic target for OA. The mechanism of miR-139 in chondrocytes may be related to its regulation on EIF4G2 and IGF1R.

  6. The Coxsackievirus B3 protease 2A-mediated cleavage of DAP5 results in the production of two truncates that exert differential effects on protein translation of the IRES-containing genes, leading to enhanced host cell death.

  7. Knockdown of EIF4G2 recapitulated the effects of mir-139, whereas restoring EIF4G2 expression rescued the mir-139 phenotype. elevated miR-139-5p expression is associated with a favorable outcome in acute myeloid leukemia.

  8. findings provide the first mechanistic insights into the function of DAP5 as a selective regulator of cap-independent translation

  9. Our results provide evidence that the tumor suppressor effect of miR-520c-3p is mediated through repression of translation while inducing senescence and that eIF4GII is a key effector of this anti-tumor activity.

  10. DAP5, a translation initiation factor shown to positively regulate the translation of various internal ribosome entry sites containing mRNAs, promotes internal ribosome entry site-driven translation of p53 mRNA.

  11. DAP5/p97 and DAP5/p86 enhanced the translation of the anti-apoptotic protein Bcl-2 and inhibited cisplatin-induced apoptosis

  12. Multiple isoforms of eIF4GII arise from multiple promoters & alternative splicing events. A non-canonical CUG initiation codon extends the eIF4GII N-terminus. The eIF4GII N-terminus plays an alternative role in initiation factor assembly.

  13. crystal structure of C-terminal region (residues 540-897) of p97/EIF4G2 (at 2.0 Angstrom resolution): sequence/structure homology with EIF4G1

  14. crystallization and preliminary X-ray diffraction analysis of the MIF4G domain of DAP5 is presented.

  15. Includes the functional analysis of a similar protein in yeast.

  16. The caspase-cleaved DAP5 protein supports internal ribosome entry site-mediated translation of death proteins

  17. proteolytic activity of HIV-1 protease on eIF4GI and eIF4GII and its implications for the translation of mRNAs

  18. endogenous eIF4GII was phosphorylated by Ca(2+)/calmodulin-dependent protein kinase I

  19. Cleavage of eIF4GII is induced in cells and in cell extracts by the FMDV leader protease (L(pro)) alone

  20. EIF4G2 transcripts exhibited three different expression patterns, downregulation was found in about 50% of the cases analyzed and EIF4G2 gene transcription was associated with invasive tumors.

Zebrafish Eukaryotic Translation Initiation Factor 4 gamma 2 (EIF4G2) interaction partners

  1. The exclusive use of the non-AUG (GUG) start site for translation initiation of EIF4G2 mRNA is evolutionary conserved in mammals and non-mammals.

Mouse (Murine) Eukaryotic Translation Initiation Factor 4 gamma 2 (EIF4G2) interaction partners

  1. analysis of the tandem MA-3 region of Pdcd4 protein and characterization of its interactions with eIF4A and eIF4G

  2. translation starts at a non-AUG translation initiation codon (GUG).

  3. in vitro and in vivo studies in human show that translation starts at a non-AUG (GUG) codon. Suggest the same in mouse based on sequence conservation.

Xenopus laevis Eukaryotic Translation Initiation Factor 4 gamma 2 (EIF4G2) interaction partners

  1. translation starts at a non-AUG translation initiation codon (GUG)

EIF4G2 Antigen Profile

Protein Summary

Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3\; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.

Gene names and symbols associated with EIF4G2

  • eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) antibody
  • eukaryotic translation initiation factor 4, gamma 2b (eif4g2b) antibody
  • eukaryotic translation initiation factor 4, gamma 2 (Eif4g2) antibody
  • eukaryotic translation initiation factor 4 gamma, 2 (EIF4G2) antibody
  • eIF4G-related protein NAT1 (nat1) antibody
  • eukaryotic translation initiation factor 4 gamma 2 (Eif4g2) antibody
  • eukaryotic translation initiation factor 4, gamma 2a (eif4g2a) antibody
  • eukaryotic translation initiation factor 4 gamma, 2 S homeolog (eif4g2.S) antibody
  • AA589388 antibody
  • AAG1 antibody
  • DAP-5 antibody
  • dap5 antibody
  • E130105L11Rik antibody
  • EIF4G2 antibody
  • eif4g2.L antibody
  • hm:zeh1307 antibody
  • im:7148615 antibody
  • nat1 antibody
  • NAT1A antibody
  • NAT1B antibody
  • Natm1 antibody
  • p97 antibody
  • wu:fa14h01 antibody
  • wu:fb44h01 antibody
  • wu:fb59c06 antibody
  • wu:fb81f07 antibody
  • wu:fb82b06 antibody
  • wu:fb98h08 antibody
  • wu:fc21b05 antibody

Protein level used designations for EIF4G2

DAP-5 , aging-associated protein 1 , death-associated protein 5 , eIF-4-gamma 2 , eIF-4G 2 , eIF4G 2 , eukaryotic translation initiation factor 4 gamma 2 , eukaryotic translation initiation factor 4G-like 1 , p97 , novel APOBEC-1 target 1 , translation repressor NAT1 , eukaryotic translation initiation factor 4 gamma, 2 , fb44h01 , Eukaryotic translation initiation factor 4 gamma 2 , translation repressor Nat1 , eIF4G-related protein NAT1 , eIF4G-related protein NAT1A , eukaryotic translation initiation factor 4, gamma 2a , eukaryotic translation initiation factor 4 gamma, 2 L homeolog , eukaryotic translation initiation factor 4 gamma, 2 S homeolog

GENE ID SPECIES
1982 Homo sapiens
286870 Bos taurus
100009236 Oryctolagus cuniculus
334618 Danio rerio
361628 Rattus norvegicus
466443 Pan troglodytes
476854 Canis lupus familiaris
705510 Macaca mulatta
100173304 Pongo abelii
13690 Mus musculus
496405 Xenopus laevis
395905 Gallus gallus
100728504 Cavia porcellus
323453 Danio rerio
100127281 Xenopus laevis
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