Eukaryotic Translation Initiation Factor 4A1 Proteins (EIF4A1)

ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. Additionally we are shipping EIF4A1 Antibodies (58) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
EIF4A1 1973 P60842
EIF4A1 13681 P60843
Rat EIF4A1 EIF4A1 287436  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top EIF4A1 Proteins at antibodies-online.com

Showing 9 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
$5,370.21
Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
$5,370.21
Details
Escherichia coli (E. coli) Human Un-conjugated SDS-PAGE analysis of Human EIF4A1 Protein. 100 μg 11 to 18 Days
$341.12
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Details
Yeast Rabbit His tag   1 mg 60 to 71 Days
$3,102.00
Details
Yeast Cow His tag   1 mg 60 to 71 Days
$3,122.17
Details
Yeast Cynomolgus His tag   1 mg 60 to 71 Days
$3,122.17
Details
Yeast Orang-Utan His tag   1 mg 60 to 71 Days
$3,122.17
Details
Yeast Chimpanzee His tag   1 mg 60 to 71 Days
$3,122.17
Details

EIF4A1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, ,
Mouse (Murine)

More Proteins for Eukaryotic Translation Initiation Factor 4A1 (EIF4A1) Interaction Partners

Human Eukaryotic Translation Initiation Factor 4A1 (EIF4A1) interaction partners

  1. Results indicate that ubiquitin specific peptidase 9, X-linked (USP9X) is a regulator of the translation initiation process via deubiquitination of eukaryotic translation initiation factor 4A1 (eIF4A1), which is a substrate of USP9X in vivo.

  2. Results suggest that rev protein, HIV-1 (Rev) regulates the association of nuclear cap-binding protein NCBP 80 kDa subunit (CBP80) and eukaryotic translation initiation factor 4A1 (eIF4AI) with the unspliced mRNA in the cytoplasm and the nucleus, respectively, during HIV-1 replication.

  3. Besides catalyzing serine synthesis, PHGDH promotes pancreatic cancer development through enhancing the translation initiations by interacting with eIF4A1 and eIF4E.

  4. RocA targets the "bi-molecular cavity" formed characteristically by eIF4A1 and a sharply bent pair of consecutive purines in the RNA to inhibit genetic translation.

  5. Star-PAP-specific polyadenylation sites usage regulates the expression of the eukaryotic translation initiation factor EIF4A1, the tumor suppressor gene PTEN and the long non-coding RNA NEAT1.

  6. our data demonstrate that the common effects of eIF4A1 and eIF4E on translation are mediated by the coding region and 3'UTR

  7. our data identify the eIF4F complex as an important upstream regulator of TORC1, which acts via TSC2 to inactivate TORC1 upon withdrawal of amino acids

  8. Our results demonstrate that miR-133a plays a pivotal role in colorectal cancer by inhibiting cell proliferation, invasion, and migration by targeting oncogenic eukaryotic translation initiation factor 4A1, which acts as a tumor suppressor and may provide a new potential therapeutic target in colorectal cancer

  9. miR-1284 can function as a new regulator to reduce gastric cancer multidrug resistant cells by targeting EIF4A1.

  10. Studies indicate a developing focus on targeting eukaryotic initiation factor 4A eIF4A1 and eIF4A2 as cancer therapy.

  11. Immunohistochemical analysis was performed on over 3000 breast tumors to investigate the relationship among expression of eIF4A1, the helicase-modulating proteins eIF4B, eIF4E and PDCD4, and clinical outcome.

  12. Collectively, these data suggested that a potential role of NS4A in antagonizing host antiviral defense is by recruiting eIF4AI and escaping the translation inhibition mediated by PKR.

  13. eIF4A functions as an adenosine triphosphate-dependent processive helicase when complexed with two accessory proteins, eIF4G and eIF4B.

  14. demonstrate that DAP5 associates with eIF2beta and eIF4AI to stimulate IRES-dependent translation of cellular mRNAs

  15. Studies indicate that eukaryotic initiation factor 4AI (EIF4AI) undergoes large conformational transitions, while unwinding RNA hairpins.

  16. Data indicate that caspase recruitment domain family, member 11 protein CARD11 has complex 5'UTRs and is sensitive to eIF4A RNA helicase inhibition.

  17. Increased Expression of EIF4A1 is associated with poor response to Brachytherapy in Cervical Cancer.

  18. report of an eIF4A RNA helicase-dependent mechanism of translational control that contributes to oncogenesis and underlies the anticancer effects of silvestrol and related compounds

  19. The E186 residue was found to be of significance for RNA-dependent ATPase activity for eIF4AI alone and in the presence of eIF4AI-binding domains of eIF4GI, binding between eIF4AI and eIF4GI domains were also significantly influenced by mutation of E186.

  20. Findings implicate phosphorylation of eIF4G1(Ser1232) by Cdk1:cyclin B and its inhibitory effects on eIF4A helicase activity in the mitotic translation initiation shift.

Mouse (Murine) Eukaryotic Translation Initiation Factor 4A1 (EIF4A1) interaction partners

  1. the central A-rich domains of BC RNAs target eIF4A, specifically inhibiting its RNA helicase activity

  2. analysis of the tandem MA-3 region of Pdcd4 protein and characterization of its interactions with eIF4A and eIF4G

  3. Pdcd4 binding to eIF4A is linked to its transformation-suppressing activity, as Pdcd4-eIF4A binding and consequent inhibition of translation are required for Pdcd4 transrepression of AP-1.

  4. The binding of pateamine to eIF4A presets the protein in the high-affinity RNA-binding state, which stimulates ATP binding, hydrolysis, and RNA unwinding.

  5. interactions between Pdcd4 and components of the translation initiation complex, namely, the RNA helicase eIF4A and the scaffolding protein eIF4G

  6. analysis of cells of eIF4GIf molecules lacking either the PABP-binding site, the eIF3-binding site, the middle domain eIF4A-binding site, or the C-terminal segment that includes the second eIF4A-binding site

EIF4A1 Protein Profile

Protein Summary

ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).

Gene names and symbols associated with EIF4A1

  • eukaryotic translation initiation factor 4A1 (EIF4A1)
  • eukaryotic translation initiation factor 4A1 (Eif4a1)
  • eukaryotic translation initiation factor 4A1 L homeolog (eif4a1.L)
  • eukaryotic translation initiation factor 4A1 (eif4a1)
  • eukaryotic initiation factor 4A-I (LOC695050)
  • eukaryotic translation initiation factor 4A1A (eif4a1a)
  • BM-010 protein
  • ddx2a protein
  • eif-4a protein
  • eIF-4A-I protein
  • Eif4 protein
  • eif4a protein
  • eIF4A-I protein
  • eif4a1 protein
  • fb49a04 protein
  • im:7143023 protein
  • wu:fb20a10 protein
  • wu:fb49a04 protein
  • wu:fc76a02 protein
  • wu:fc96c01 protein
  • wu:fd15g03 protein

Protein level used designations for EIF4A1

ATP-dependent RNA helicase eIF4A-1 , eukaryotic initiation factor 4A-I , eukaryotic initiation factor 4AI , eukaryotic translation initiation factor 4A , eIF-4A-I , eIF4A-I , initiation factor eIF-4A long form , translation initiation factor eIF4A I , eukaryotic translation initiation factor 4A1 , eukaryotic translation initiation factor 4A-like , eukaryotic initiation factor 4A-I-like

GENE ID SPECIES
1973 Homo sapiens
100173783 Pongo abelii
504958 Bos taurus
13681 Mus musculus
443739 Xenopus laevis
496556 Xenopus (Silurana) tropicalis
695050 Macaca mulatta
100061902 Equus caballus
100101929 Sus scrofa
100355889 Oryctolagus cuniculus
100388544 Callithrix jacchus
100582095 Nomascus leucogenys
386634 Danio rerio
287436 Rattus norvegicus
748995 Pan troglodytes
100688577 Canis lupus familiaris
100713267 Cavia porcellus
Selected quality suppliers for EIF4A1 Proteins (EIF4A1)
Did you look for something else?