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FBXO3 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box.
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we report the X-ray structure of the human FBxo3 ApaG domain, residues 278-407, at 2.0 A resolution
AIRE (show AIRE ELISA Kits), which is phosphorylated on two specific residues near its N terminus, then binds to the F-box protein 3 (FBXO3) E3 ubiquitin ligase. In turn, this SCF (show KITLG ELISA Kits)(FBXO3) (SKP1 (show SKP1 ELISA Kits)-CUL1 (show CUL1 ELISA Kits)-F box) complex ubiquitylates AIRE (show AIRE ELISA Kits), increases its binding to the positive transcription elongation factor b (P-TEFb (show CDK9 ELISA Kits)), and potentiates its transcriptional activity.
Fbxo3 promotes the proteasomal degradation of Smurf1 (show SMURF1 ELISA Kits). Fbxo3 promotes the poly-ubiquitination of Smurf1 (show SMURF1 ELISA Kits).
Virulence factor NSs of rift valley fever virus recruits the FBXO3 to degrade subunit p62 of general transcription factor TFIIH.
controls TRAF (show TRAF1 ELISA Kits) adaptor stability to regulate inflammation
Fbx3 formed SCF(Fbx3) ubiquitin ligase and promoted the degradation of HIPK2 and p300 by the ubiquitin-proteasome pathway
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants diverging at the 3' end.
F-box only protein 3
, F-box protein FBX3
, F-box protein FBA
, F-box protein 3
, F-box only protein 3-like
, f-box only protein 3-like