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FBXO8 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. Additionally we are shipping F-Box Protein 8 Antibodies (55) and F-Box Protein 8 Proteins (7) and many more products for this protein.
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Study demonstrates that down-regulation of FBX8 in hepatocellular carcinoma (HCC) correlates with poor survival of patients. All of the functional experiments confirm FBX8 as a tumor suppressor in the progression of HCC. The preferential down-regulation of FBX8 in HCC patients with invasion and metastasis suggested that FBX8 may be a significant biomarker for HCC progression.
FBX8 as a metastasis suppressor that functions through mTOR signaling pathway and has significant prognostic power.
FBX8 down-expression was an independent prognostic indicator for glioma patient's survival.
FBX8 was markedly down-regulated in gastric cancer tissues. Knocking down FBX8 promoted proliferation and invasion in tumor cell line. Patients with low FBX8 had poor prognosis.
FBX8 is a novel c-Myc binding protein and that c-Myc induces cell invasive activity
Fbx8, an F-box protein bearing the Sec7 domain, mediates ubiquitination of Arf6.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It contains a C-terminal amino acid sequence that bears a significant similarity with a portion of yeast Sec7p, a critical regulator of vesicular protein transport. This human protein may interact with ADP-ribosylation factor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity.
F-box protein 8
, F-box only protein 8
, F-box only protein 8-like
, f-box only protein 8-like
, F-box protein Fbx8
, F-box/SEC7 protein FBS