ICK and FBX9 are divergently transcribed from a bidirectional promoter that is GC-rich and contains a CpG island.
FBXO9 directly interacted with PPAR gamma through the activation function-1 domain and ligand-binding domain. FBXO9 decreased the protein stability of PPAR gamma through induction of ubiquitination.
ICK and FBX9 are divergently transcribed from a bidirectional promoter that is GC-rich and contains a CpG island.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates at least 3 transcript variants diverging at the 5' terminus.
F-box protein 9 , F-box only protein 9 , f-box only protein 9-like , F-box protein Fbx9 , cross-immune reaction antigen 1 , renal carcinoma antigen NY-REN-57
GENE ID | SPECIES |
---|---|
394601 | Xenopus (Silurana) tropicalis |
712024 | Macaca mulatta |
6045930 | Culex quinquefasciatus |
10904037 | Trichinella spiralis |
100069351 | Equus caballus |
100152568 | Sus scrofa |
100195096 | Salmo salar |
100355202 | Oryctolagus cuniculus |
100451955 | Pongo abelii |
100543868 | Meleagris gallopavo |
100555189 | Anolis carolinensis |
100582299 | Nomascus leucogenys |
26268 | Homo sapiens |
325469 | Danio rerio |
421895 | Gallus gallus |
474940 | Canis lupus familiaris |
511798 | Bos taurus |
71538 | Mus musculus |
300849 | Rattus norvegicus |
380290 | Xenopus laevis |
462774 | Pan troglodytes |
101107741 | Ovis aries |