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Members of the F-box protein family, such as FBXL12, are characterized by an approximately 40-amino acid F-box motif. Additionally we are shipping FBXL12 Kits (12) and FBXL12 Proteins (6) and many more products for this protein.
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Human Polyclonal FBXL12 Primary Antibody for ICC, IF - ABIN249992
Winston, Koepp, Zhu, Elledge, Harper: A family of mammalian F-box proteins. in Current biology : CB 1999
Show all 2 Pubmed References
Study found that Fbl12 binds and ubiquitinates p21 which allows its stability. In addition, Fbl12 regulates default degradation under basal conditions but not under UV-stimulated conditions. These findings elucidate novel mechanisms that underlie the regulation of p21 expression level in cells.
FBXL12 plays a key role in the down-regulation of ALDH3 activity in trophoblast stem cells and thus initiates trophoblast differentiation during placental development.
Fbxl12-induced CaMKI degradation attenuates p27 phosphorylation at these sites in early G1 and iii) activation of CaMKI during G1 transition followed by p27 phosphorylation appears to be upstream to other p27 phosphorylation events
Study investigated the role of FBXL12 in T-cell development by examination of FBXL12-null mice, finding that the FBXL12-ALDH3 axis plays a key role in regulation of the positive selection of T cells.
Members of the F-box protein family, such as FBXL12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1\; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004
F-box protein FBL12
, F-box/LRR-repeat protein 12
, F-box and leucine-rich repeat protein 12
, F-box protein containing leucine repeats 12
, F-box/LRR-repeat protein 12-like
, f-box/LRR-repeat protein 12-like