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F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Additionally we are shipping FBXW2 Antibodies (50) and FBXW2 Kits (13) and many more products for this protein.
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BTrCP-FBXW2-SKP2 axis forms an oncogene-tumour suppressor-oncogene cascade to control cancer cell growth with FBXW2 acting as a tumour suppressor by promoting SKP2 degradation.
RACK1 (show GNB2L1 Proteins) competes with GCM1 (show GCM1 Proteins) for FBW2 and thereby prevents GCM1 (show GCM1 Proteins) ubiquitination, which is also supported by the observation that GCM1 (show GCM1 Proteins) is destabilized in RACK1 (show GNB2L1 Proteins)-knockdown BeWo placental cells
the SCF(hFBW2) E3 complex has a key role in targeting hGCMa to the ubiquitin-proteasome degradation system
UBE2D2 (show UBE2D2 Proteins) is required for GCMa (show GCM1 Proteins) ubiquitination and for association with the SCF (show KITLG Proteins)(FBXW2) complex.
F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats.
F-box and WD repeat domain containing 2
, F-box and WD-40 domain protein 2
, F-box and WD-40 domain-containing protein 2
, F-box/WD repeat-containing protein 2