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Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP.
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The t allele of Fgd2 is overexpressed in testis compared with wild type, a loss-of-function allele of Fgd2 generated by gene targeting reduces the transmission ratio of the t haplotype t(h49), directly demonstrating the role of Fgd2 as Distorter.
FGD2 has a role in leukocyte signaling and vesicle trafficking in cells specialized to present antigen in the immune system
Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5- bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4- monophosphate and phosphatidylinositol 3-monophosphate (By similarity).
FYVE, RhoGEF and PH domain-containing protein 2
, FYVE, RhoGEF and PH domain containing 2
, Fgd1 family, member 2
, Fgd2-like protein
, faciogenital dysplasia homolog 2
, faciogenital dysplasia protein 2
, t-complex distorter 2
, FGD1 family, member 2
, FLJ00276 protein
, zinc finger FYVE domain-containing protein 4