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FAM19A4 is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. Additionally we are shipping FAM19A4 Proteins (10) and and many more products for this protein.
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FAM19A4 methylation analysis may serve as an auxiliary screening method for diagnosis of cervical (pre)cancer.
Hypermethylation of FAM19A4/miR124-2 in the self-sample was tested in a quantitative methylation specific PCR and compared between lesions caused by HPV16/18 and other hrHPV genotypes. There were no differences in the percentages of positive FAM19A4/miR124-2 methylation assays between lesions caused by HPV16/18 (73.8% in CIN3+) or other hrHPV genotypes (66.7% in CIN3+) (p=0.538).
With a similarly good clinical performance in both sample types, combined FAM19A4 methylation analysis and HPV16/18 genotyping provides a feasible triage strategy for hrHPV-positive women, with direct applicability on self-samples
FAM19A4/mir124-2 methylation analysis performs equally well in HPV-positive lavage- and brush self-samples to identify women with CIN3+. In combination with HPV16/18 genotyping, significantly higher CIN3+ sensitivities are obtained, at decreased specificity.
FAM19A4 is a novel ligand of formyl peptide receptor 1.
among high risk HPV-positive women from an outpatient population aged >/= 30 years, methylation analysis of FAM19A4 is an attractive marker for the identification of women with high-grade cervical intraepithelial neoplasia and cervical cancer
High methylation of FAM19A4 is associated with cervical carcinomas.
TAFA4 is required to maintain the normal threshold of injury-induced mechanical and chemical pain hypersensitivity and strongly support a potential role of TAFA4 as a potent analgesic in the settings of inflammation and neuropathy.
This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants have been observed for this gene.
chemokine-like protein TAFA-4
, protein FAM19A4
, family with sequence similarity 19, member A4
, TAFA4 protein
, family with sequence similarity 19 (chemokine (C-C motif)-like), member A4