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May act as a defensin against invading fungal microorganisms.. Additionally we are shipping FAM3A Antibodies (48) and FAM3A Proteins (5) and many more products for this protein.
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Fam3A may regulate high glucose-induced reactive oxygen species production in HUVECs via the p38 MAPK signaling pathway.
These results suggest that C/EBPbeta plays an important role in regulating FAM3A promoter activity and FAM3A inhibits adipocyte differentiation.
In the present study, we report a putative human homologue of the antimicrobial Drosophila-derived drosomycin, designated drosomycin-like defensin (DLD), with specific antifungal activity.
FAM3A plays crucial roles in the regulation of glucose and lipid metabolism in the liver, where it activates the PI3K-Akt signaling pathway by way of a Ca(2+) /CaM-dependent mechanism
Upregulation of FAM3A by PPARgamma activation is correlated with increased pAkt level in liver cells
Expressed prominently in the vascular endothelium, particularly capillaries, also in islets of Langerhans.
Study identified Fam3a, a cytokine-like protein, as a major Stat3 downstream effector in muscle stem cells and demonstrated that Fam3a is required for muscle stem cell commitment and skeletal muscle development. These findings indicate that Fam3a is a Stat3-regulated secreted factor that promotes muscle stem cell oxidative metabolism and differentiation.
FAM3A protects against liver IRI by activating Akt survival pathways, repressing inflammation and attenuating oxidative stress. Moreover, the protective effects of PPARgamma agonist(s) on liver IRI are dependent on FAM3A-ATP-Akt pathway.
FAM3A enhances the adipogenesis of preadipocytes by activating ATP-P2 receptor-Akt pathway. Under obese condition, a decrease in FAM3A expression in adipose tissues plays important roles in the development of adipose dysfunction and type 2 diabetes.
FAM3A has a protective role against cytotoxicity via regulating the CHOP-Wnt pathway in mitochondria.
May act as a defensin against invading fungal microorganisms.
family with sequence similarity 3, member A
, cytokine-like protein 2-19
, protein FAM3A