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FAM3C is a member of the family with sequence similarity 3 (FAM3) family and encodes a secreted protein with a GG domain. Additionally we are shipping FAM3C Antibodies (74) and FAM3C Proteins (17) and many more products for this protein.
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The ILEI appears to play a crucial role in mediating TGF-beta1 (show TGFB1 ELISA Kits)-induced EMT (show ITK ELISA Kits) through the Akt (show AKT1 ELISA Kits) and ERK (show EPHB2 ELISA Kits) pathways, which may provide a therapeutic target for the treatment of fibrotic kidney diseases.
Covalent dimerization of ILEI is associated with breast cancer metastasis.
Data suggest that ILEI does not form interleukin-like four helix-bundle structures; ILEI exists as monomers and as covalent dimers; ILEI dimer exhibits a trans-linked domain swap converting an intramolecular disulfide to an intermolecular disulfide; dimeric ILEI appears to be involved in neoplastic invasiveness.
Results demonstrate that phenotype switching regulates ILEI expression, and that ILEI regulates partial phenotype switching in MITF (show MITF ELISA Kits)-low melanoma cell lines.
Ectopic overexpression of UBE4A, but not UBE3C, in cells was downregulated in vitro migration and invasion in these cells. Cumulatively, our data reveals a novel post-translational regulatory mechanism of regulating ILEI1 expression, a protein required for metastatic progression in prostate cancer cells
Study used immunohistochemical staining and biochemical fractionation to examine the regional distribution and subcellular localization of ILEI in mouse brains and in autopsy brains of patients with Alzheimer's disease; results suggest that a decline of ILEI expression may cause accumulation of Abeta (show APP ELISA Kits) in the brain and the eventual development of Alzheimer's disease.
FAM3C expression was dramatically increased in esophageal squamous cell carcinoma and might serve as a valuable prognostic indicator for esophageal squamous cell carcinoma patients after surgery
Altered subcellular ILEI localization strongly correlates with high tumor cell-associated uPAR (show PLAUR ELISA Kits) protein expression.
Our findings indicate that cytoplasmic ILEI expression is a potential marker of EMT (show ITK ELISA Kits) and tumour progression in colorectal cancer. ILEI is an independent predictive factor associated with poor prognosis in colorectal cancer.
ILEI could induce, as well as maintain, CD24 (show CD24 ELISA Kits)(low)CD44 (show CD44 ELISA Kits)(high) subpopulation in A549 cells treated with TGF-beta (show TGFB1 ELISA Kits), which might explain its capability to induce metastatic progression.
Data suggest that Ilei does not form interleukin-like four helix-bundle structures; Ilei exists as monomers and as covalent dimers; Ilei dimer exhibits a trans-linked domain swap converting an intramolecular disulfide to an intermolecular disulfide; dimeric Ilei appears to be involved in neoplastic invasiveness.
overexpression of Fam3c caused reduction of Runx2 (show RUNX2 ELISA Kits) expression at both mRNA and protein levels. Fam3c was localized in the cytoplasm and it was not secreted outside the cell during osteoblast differentiation and therefore, may function intracellularly. Furthermore, Fam3c and TGF-beta1 (show TGFB1 ELISA Kits) were found to regulate each other reciprocally
In obese diabetic mice, FAM3C expression was reduced in the liver, and hepatic FAM3C restoration improved insulin resistance, hyperglycemia, and fatty liver. FAM3C overexpression increased the expression of heat shock factor 1 (HSF1), calmodulin (CaM), and phosphorylated Akt and reduced that of gluconeogenic and lipogenic genes in diabetic mouse livers with the suppression of gluconeogenesis and lipid deposition.
TGF-beta (show TGFB1 ELISA Kits) modulates the expression of Dab2 (show DAB2 ELISA Kits) and ILEI mRNA required for epithelial-mesenchymal transdifferentiation by inducing phosphorylation of hnRNP E1 (show PCBP1 ELISA Kits), resulting in its release from a structural, 33-nucleotide BAT element in the 3'UTR (show UTS2R ELISA Kits) of Dab2 (show DAB2 ELISA Kits) and ILEI.
FAM3C orthologous protein, may be involved in cell differentiation and proliferation during inner ear embryogenesis
ILEI is overexpressed and/or altered in intracellular localization in multiple human tumors.
ILEI requires cooperation with oncogenic Ras to govern hepatocellular EMT (show ITK ELISA Kits) through mechanisms involving PDGF-R/beta (show PDGFRB ELISA Kits)-catenin (show CTNNB1 ELISA Kits) and PDGF (show PDGFA ELISA Kits)-R/Stat3 (show STAT3 ELISA Kits) signaling.
This gene is a member of the family with sequence similarity 3 (FAM3) family and encodes a secreted protein with a GG domain. A change in expression of this protein has been noted in pancreatic cancer-derived cells.
hypothetical protein LOC549860
, Protein FAM3C
, family with sequence similarity 3, member C
, protein FAM3C
, interleukin-like EMT inducer
, predicted osteoblast protein
, FAM3C-like protein