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Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon.. Additionally we are shipping FAM46C Proteins (6) and many more products for this protein.
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Study shows that FAM46C, a tumor suppressor for hepatocellular carcinoma, is important for the anti-proliferation and proapoptotic effects of norcantharidin.
Reduced FAM46C mRNA expression levels were associated with Gastric Cancer.
data strengthen the growing evidence that the FAM46C gene is involved in the pathogenesis of MM as a potential tumour suppressor, although its role remains to be clarified.
FAM46C is a poly(A) polymerase and that loss of function of FAM46C drives multiple myeloma through the destabilisation of endoplasmic reticulum response transcripts.
FAM46C mutation as a contributor to myeloma pathogenesis and disease progression via perturbation in plasma cell differentiation and endoplasmic reticulum homeostasis.
Data indicate that when cases with FAM46C deletion or mutation were considered together, they were strongly associated with impaired overall survival (OS) in the intensive treatment setting.
FAM46C protein is strongly induced during activation of primary splenocytes and that B lymphocytes isolated from newly generated FAM46C KO mice proliferate faster than those isolated from their WT littermates.
Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon.