Fat Mass and Obesity-Associated (FTO) ELISA Kits

FTO is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of FTO is not known. Additionally we are shipping FTO Antibodies (158) and FTO Proteins (10) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
FTO 79068 Q9C0B1
FTO 26383 Q8BGW1
FTO 291905 Q2A121
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Top FTO ELISA Kits at antibodies-online.com

Showing 3 out of 12 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human
100 Tests Log in to see 2 to 3 Days
$835.00
Details
Rat
  96 Tests Log in to see 2 to 3 Days
$779.90
Details
Mouse
  96 Tests Log in to see 11 to 18 Days
$589.86
Details

More ELISA Kits for FTO Interaction Partners

Human Fat Mass and Obesity-Associated (FTO) interaction partners

  1. Considering FTO's critical role in many diseases, FTO may become a new promising target for the diagnosis and treatment of various diseases in the near future, especially for specific types of cancers, such as acute myeloid leukaemia, glioblastoma and breast cancer

  2. Physical activity modified the effect of FTO on body mass index change in Japanese boys

  3. Data show that the mRNA level of FTO is elevated in cervical squamous cell carcinoma (CSCC) tissues. FTO enhances the chemo-radiotherapy resistance both in vitro and in vivo through regulating expression of beta-catenin by reducing m(6) A levels in its mRNA transcripts and in turn increases ERCC1 activity.

  4. The risk of obesity in Mongolian individuals carrying rs9939609 AT genotype was 1.312 times higher and the risk in those carrying AA genotype was 1.896 times higher than in individuals with TT genotype. The body weight, BMI, WC, HC, and WHR in individuals with rs9939609 AA and AT genotypes were significantly higher than in those with TT genotype.

  5. Bi-directional relationship between BMI and affective symptoms across the life span, modified by the FTO rs9939609 polymorphism.

  6. We showed that MC4R rs17782313 and FTO rs9939609 were positively associated with zBMI, with weak and very weak effects, respectively, suggesting a very scarce contribution to childhood obesity.

  7. the minor allele A of the rs9939609 has a significant association with increasing BMI values in the Emirati population

  8. There is an association of FTO rs9939609 A/A genotype and impaired fasting glucose and insulin resistance. Homozygous A genotype diabetic patients may be more vulnerable to blood glucose fluctuation.

  9. Our results suggested that genetic variants in the FTO gene were strongly associated with BMI in Chinese women

  10. rs8050136 A/C and rs1588413 C/T associated with polycystic ovary syndrome susceptibility

  11. Mechanistically, FTO enhanced MZF1 expression by reducing m(6)A levels and mRNA stability in MZF1 mRNA transcript, leading to oncogenic functions.

  12. Nineteen single nucleotide polymorphisms in the FTO gene were tested. Allelic analysis showed that allele T of SNP rs1121980 was a risk allele. Our study suggests that rs1121980 can become a biomarker for the screening and prognosis of Intervertebral Disc Degeneration

  13. FTO rs9939609 variant may not be associated with insulin resistance in Indonesian obese female adolescents.

  14. FTO polymorphisms appear to be universally associated with the risk of obesity, and further investigation into this genetic locus may provide clues for potential therapeutic targets

  15. The polymorphism of FTO gene rs17817449 and GNB3 gene rs5443 (C825T) may be a genetic determinant of obesity in Saudi population whereas impact of MC4R Asn274Ser change could not be detected.

  16. A lack of association between FTO polymorphismsand GDM risk.

  17. Our findings demonstrate a relationship between C allele carriers on the FTO gene and a predisposition to a higher fat mass and body fat percentage.

  18. FTO variant is not associated with osteoarthritis in the Chinese Han population.

  19. This study confirms an association between the FTO gene and adiposity markers in Chilean adults, which is independent of major confounding factors.

  20. FTO gene polymorphisms are associated with variability of HDL-cholesterol concentrations which may lead to increased CVD risk in patients with acromegaly who are risk-allele carriers.

Mouse (Murine) Fat Mass and Obesity-Associated (FTO) interaction partners

  1. In C57bl/6 model, glycaemic index of maternal dietary carbohydrates differentially alters Fto and Lep expression in offspring.

  2. Mutations in genes implicated in body mass and timing of puberty in the general population may contribute to the pathogenesis of self-limited delayed puberty. Fto+/- mice displayed a significantly delayed timing of pubertal onset as well.

  3. FTO demethylase activity is essential for normal bone development and mineralization, a previously unreported FTO function.

  4. FTO is critically involved in insulin defects-related Alzheimer's disease.

  5. This is the first study revealing the presence of a parallel increase in expressions of FTO and HNRNPK proteins. This increase may codictate the metabolic changes occurring in the cell and may attribute a significance to HNRNPK in FTO-associated transformations.

  6. Contextual fear conditioning decreased FTO levels in neurons from the hippocampus.

  7. The involvement of mTOR-PGC-1alpha pathway in the connection between FTO and muscle differentiation is displayed.

  8. In vivo experiments revealed that Fto(-/-) and Fto(+/-) mice were more susceptible to thiopurine-induced myelosuppression than wild-type mice.

  9. propose that PKCbeta acts to suppress the degradation of FTO protein and reveals the associated role of PKCbeta and FTO in adipogenesis, suggesting a new pathway that affects the development of obesity and metabolic diseases

  10. the results of this study indicate that the effects of FTO-associated SNPs on energy homeostasis are due in part to the effects of these genetic variations on hypothalamic FTO, RPGRIP1L, and possibly other genes.

  11. FTO may have a deleterious role in hepatic cells during lipotoxic conditions, and up-regulation of FTO may contribute to the increased liver damage in non-alcoholic steatohepatitis

  12. Fto deficiency affects the gene and miR130/miR378 expression involved in brown adipogenesis and browning of white adipose tissue in mice.

  13. Here we show that FTO expression is increased after ureteral obstruction and renal fibrosis.

  14. Taken together, the results suggest that Fto regulates the proliferation and differentiation of 3T3-L1 cells via multiple mechanisms, including PPARgamma and PI3K/Akt signaling.

  15. These results reveal that FTO regulates fatty acid mobilization in adipocytes and thus body weight in part through posttranscriptional regulation of Angptl4.

  16. FTO-dependent N6-methyladenosine demethylation may be affected by betaine.

  17. FTO modulates circadian rhythms and inhibits the CLOCK-BMAL1-induced transcription.

  18. FTO expression and N6-methyladenosine levels are inversely correlated during adipogenesis. FTO depletion blocks differentiation and only catalytically active FTO restores adipogenesis.

  19. FTO is present in both the nucleus and cytoplasm, with a mobile fraction that shuttles between both cellular compartments, possibly by interaction with XPO2.

  20. FTO plays an important role in the development of metabolic disorders and is an interesting target for therapeutic agents.

Pig (Porcine) Fat Mass and Obesity-Associated (FTO) interaction partners

  1. Studied role of FTO alpha-ketoglutarate dependent dioxygenase (FTO) in adipogenesis of intramuscular adipocytes.

  2. In this study, the authors characterise the nucleotide variability and haplotype diversity of the porcine fat mass and obesity-associated (FTO) gene in breeds having different predispositions to fat deposition traits.

  3. In pig, the FTO gene influences back fat depth in the commercial populations.

  4. This study will provide clues for obtaining a better understanding of the porcine FTO gene function.

  5. The results of the association analyses confirmed the effect of the FTO mutation on obesity-related traits in the Italian Duroc pigs (P < 0.01) and in the commercial pigs.

  6. transcriptional levels in a range of different tissues under different physiological conditions, and physical mapping of gene

  7. The porcine fat mass and obesity associated (FTO) gene is associated with fat deposition in Italian Duroc pigs.

  8. Twelve variants including ten SNPs and two indels were detected, and then five SNPs within different genomic regions were genotyped in the ISU Berkshire x Yorkshire pig resource family.

Cow (Bovine) Fat Mass and Obesity-Associated (FTO) interaction partners

  1. 34 FTO polymorphisms revealed significant association of FTO variants with lean meat percentage in Simmental and Brown cattle breeds.

  2. association signals not only provided evidence for at least two causative mutations in the FTO locus with a functional effect on milk but also milk protein yield

  3. Haplotype frequencies and linkage disequilibrium (LD) coefficients of FTO single nucleotide polymorphisms in three Chinese indigenous cattle breeds were analyzed.

FTO Antigen Profile

Antigen Summary

This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes.

Gene names and symbols associated with FTO

  • FTO, alpha-ketoglutarate dependent dioxygenase (FTO) antibody
  • fat mass and obesity associated (Fto) antibody
  • FTO, alpha-ketoglutarate dependent dioxygenase (Fto) antibody
  • fat mass and obesity associated L homeolog (fto.L) antibody
  • AW743446 antibody
  • mKIAA1752 antibody
  • RGD1305121 antibody

Protein level used designations for FTO

alpha-ketoglutarate-dependent dioxygenase FTO , fat mass and obesity-associated protein , protein fto , protein fatso , fat mass and obesity associated protein , Protein fatso

GENE ID SPECIES
79068 Homo sapiens
26383 Mus musculus
478125 Canis lupus familiaris
100127165 Sus scrofa
291905 Rattus norvegicus
100060565 Equus caballus
618622 Bos taurus
100125353 Ovis aries
447305 Xenopus laevis
100173222 Pongo abelii
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