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FTO is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of FTO is not known. Additionally we are shipping FTO Antibodies (148) and FTO Proteins (10) and many more products for this protein.
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There is an association of FTO rs9939609 A/A genotype and impaired fasting glucose and insulin (show INS ELISA Kits) resistance. Homozygous A genotype diabetic patients may be more vulnerable to blood glucose fluctuation.
Our results suggested that genetic variants in the FTO gene were strongly associated with BMI in Chinese women
Mechanistically, FTO enhanced MZF1 expression by reducing m(6)A levels and mRNA stability in MZF1 mRNA transcript, leading to oncogenic functions.
Nineteen single nucleotide polymorphisms in the FTO gene were tested. Allelic analysis showed that allele T of SNP rs1121980 was a risk allele. Our study suggests that rs1121980 can become a biomarker for the screening and prognosis of Intervertebral Disc Degeneration
FTO rs9939609 variant may not be associated with insulin (show INS ELISA Kits) resistance in Indonesian obese female adolescents.
FTO polymorphisms appear to be universally associated with the risk of obesity, and further investigation into this genetic locus may provide clues for potential therapeutic targets
The polymorphism of FTO gene rs17817449 and GNB3 (show GNB3 ELISA Kits) gene rs5443 (C825T) may be a genetic determinant of obesity in Saudi population whereas impact of MC4R (show MC4R ELISA Kits) Asn274Ser change could not be detected.
A lack of association between FTO polymorphismsand GDM risk.
Our findings demonstrate a relationship between C allele carriers on the FTO gene and a predisposition to a higher fat mass and body fat percentage.
FTO variant is not associated with osteoarthritis in the Chinese Han population.
Mutations in genes implicated in body mass and timing of puberty in the general population may contribute to the pathogenesis of self-limited delayed puberty. Fto+/- mice displayed a significantly delayed timing of pubertal onset as well.
FTO demethylase activity is essential for normal bone development and mineralization, a previously unreported FTO function.
FTO is critically involved in insulin (show INS ELISA Kits) defects-related Alzheimer's disease.
This is the first study revealing the presence of a parallel increase in expressions of FTO and HNRNPK (show HNRNPK ELISA Kits) proteins. This increase may codictate the metabolic changes occurring in the cell and may attribute a significance to HNRNPK (show HNRNPK ELISA Kits) in FTO-associated transformations.
Contextual fear conditioning decreased FTO levels in neurons from the hippocampus.
The involvement of mTOR (show FRAP1 ELISA Kits)-PGC-1alpha (show PPARGC1A ELISA Kits) pathway in the connection between FTO and muscle differentiation is displayed.
In vivo experiments revealed that Fto(-/-) and Fto(+/-) mice were more susceptible to thiopurine-induced myelosuppression than wild-type mice.
propose that PKCbeta acts to suppress the degradation of FTO protein and reveals the associated role of PKCbeta and FTO in adipogenesis, suggesting a new pathway that affects the development of obesity and metabolic diseases
the results of this study indicate that the effects of FTO-associated SNPs on energy homeostasis are due in part to the effects of these genetic variations on hypothalamic FTO, RPGRIP1L (show RPGRIP1L ELISA Kits), and possibly other genes.
FTO may have a deleterious role in hepatic cells during lipotoxic conditions, and up-regulation of FTO may contribute to the increased liver damage in non-alcoholic steatohepatitis
Studied role of FTO alpha-ketoglutarate dependent dioxygenase (FTO) in adipogenesis of intramuscular adipocytes.
In this study, the authors characterise the nucleotide variability and haplotype diversity of the porcine fat mass and obesity-associated (FTO) gene in breeds having different predispositions to fat deposition traits.
In pig, the FTO gene influences back fat depth in the commercial populations.
This study will provide clues for obtaining a better understanding of the porcine FTO gene function.
The results of the association analyses confirmed the effect of the FTO mutation on obesity-related traits in the Italian Duroc pigs (P < 0.01) and in the commercial pigs.
The porcine fat mass and obesity associated (FTO) gene is associated with fat deposition in Italian Duroc pigs.
34 FTO polymorphisms revealed significant association of FTO variants with lean meat percentage in Simmental and Brown cattle breeds.
association signals not only provided evidence for at least two causative mutations in the FTO locus with a functional effect on milk but also milk protein (show CSN2 ELISA Kits) yield
Haplotype frequencies and linkage disequilibrium (LD) coefficients of FTO single nucleotide polymorphisms in three Chinese indigenous cattle breeds were analyzed.
This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes.
alpha-ketoglutarate-dependent dioxygenase FTO
, fat mass and obesity-associated protein
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, fat mass and obesity associated protein
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