Fat Mass and Obesity-Associated (FTO) ELISA Kits

FTO is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of FTO is not known. Additionally we are shipping FTO Antibodies (156) and FTO Proteins (10) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
FTO 79068 Q9C0B1
FTO 26383 Q8BGW1
FTO 291905 Q2A121
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Top FTO ELISA Kits at antibodies-online.com

Showing 3 out of 12 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human
100 Tests Log in to see 2 to 3 Days
$835.00
Details
Rat
  96 Tests Log in to see 2 to 3 Days
$779.90
Details
Mouse
  96 Tests Log in to see 11 to 18 Days
$589.86
Details

More ELISA Kits for FTO Interaction Partners

Human Fat Mass and Obesity-Associated (FTO) interaction partners

  1. allelic variants in FTO raise obesity risk through impaired central nervous system satiety processing, thereby increasing food intake

  2. Study performed genome-wide association studies for diabetic nephropathy in Japanese patients with type 2 diabetes. One SNP locus, FTO locus, showed a significant association with susceptibility to diabetic nephropathy, and the association attained a genome-wide significant level.

  3. Our findings provide a structural basis for understanding the catalytic mechanism through which FTO demethylates its multiple substrates and pave the way forward for the structure-guided design of selective chemicals for functional studies and potential therapeutic applications

  4. These results support the hypothesis that female obesity is strongly related to all 3 variants of the FTO gene and perhaps a specific composition of microbiota in saliva due to dietary habits. Considering the bimodal distribution of the SNPs and bacterial content of saliva in obese women taken together are factors to consider for risk of obesity.

  5. Compared to TT homozygotes, individuals carrying the obesity-susceptible A allele had higher total food cravings, which correlated with higher BMI. Additionally, food cravings declined with age, but this age effect differed across variants of FTO rs9939609: while TT homozygotes showed the typical age-related decline in food cravings, there was no such decline among A carriers.

  6. The variant rs9939609 of the FTO gene was associated with T2DM in Palestine.

  7. Assessment of the sufficiency of Moscow population with folic acid, depending on the combined effect of polymorphism of MTHFR and FTO genes.

  8. A haplotype in the first intron of the FTO gene had a strong association with obesity.

  9. The presence of FTO and/or PPARgamma SNPs might be related to a genetic predisposition to metabolic syndrome.

  10. in Tunisian population, the rs9939609 polymorphism of FTO gene is associated with obesity, especially obesity class III in women.

  11. highlights a lack of association of FTO rs9939609T>A genotypes and posttransplant weight gain, plasma lipids, and fasting blood glucose in kidney transplantation

  12. Knock-in HeLa cells harboring the ubiquitin-deficient K216R mutation displayed a slower rate of FTO turnover, resulting in an increase in the level of FTO as well as enhanced phosphorylation of the ribosomal S6 kinase.

  13. This meta-analysis shows that the FTO rs9939609 polymorphism in the gene is a risk factor for obesity in children and adolescents with the presence of the A allele, both homozygous genotype AA situation, as heterozygous AT.

  14. The FTO gene may has a critical role in obesity and breast cancer.FTO association with body weight and boy composition. [review]

  15. Modelling studies reveal conformational dynamics influence structure-function relationships of AlkB and FTO. The FTO N- and C-terminal domains move in respect to one another in a manner likely important for substrate binding. Substitutions, including clinically observed ones, influencing catalysis contribute to the network of correlated motions in AlkB and FTO.

  16. The GCKR rs780094, SLC30A8 rs13266634 and FTO rs9939609 SNPs were demonstrated to be the potential biomarkers for gestational diabetes risk prediction.

  17. The mean of leptin level in diabetic women was lower than non-diabetic women (significant difference). However, the level of leptin was not statistically significant between three genotypes, and odds ratio of FTO rs9939609 was higher in diabetic women in comparison with non-diabetic women.

  18. El presente estudio muestra por primera vez una asociacion positiva entre el grFTO y mayor consumo energetico en poblacion adulta chilena, independiente de las variables de confusion. A pesar del posible rol de esta asociacion en el desarrollo de obesidad, es importante considerar la naturaleza multifactorial de esta patologia, en la cual los estilos de vida tienen un rol fundamental en su curso y desarrollo.

  19. Considering FTO's critical role in many diseases, FTO may become a new promising target for the diagnosis and treatment of various diseases in the near future, especially for specific types of cancers, such as acute myeloid leukaemia, glioblastoma and breast cancer

  20. Physical activity modified the effect of FTO on body mass index change in Japanese boys

Mouse (Murine) Fat Mass and Obesity-Associated (FTO) interaction partners

  1. In C57bl/6 model, glycaemic index of maternal dietary carbohydrates differentially alters Fto and Lep expression in offspring.

  2. Mutations in genes implicated in body mass and timing of puberty in the general population may contribute to the pathogenesis of self-limited delayed puberty. Fto+/- mice displayed a significantly delayed timing of pubertal onset as well.

  3. FTO demethylase activity is essential for normal bone development and mineralization, a previously unreported FTO function.

  4. FTO is critically involved in insulin defects-related Alzheimer's disease.

  5. This is the first study revealing the presence of a parallel increase in expressions of FTO and HNRNPK proteins. This increase may codictate the metabolic changes occurring in the cell and may attribute a significance to HNRNPK in FTO-associated transformations.

  6. Contextual fear conditioning decreased FTO levels in neurons from the hippocampus.

  7. The involvement of mTOR-PGC-1alpha pathway in the connection between FTO and muscle differentiation is displayed.

  8. In vivo experiments revealed that Fto(-/-) and Fto(+/-) mice were more susceptible to thiopurine-induced myelosuppression than wild-type mice.

  9. propose that PKCbeta acts to suppress the degradation of FTO protein and reveals the associated role of PKCbeta and FTO in adipogenesis, suggesting a new pathway that affects the development of obesity and metabolic diseases

  10. the results of this study indicate that the effects of FTO-associated SNPs on energy homeostasis are due in part to the effects of these genetic variations on hypothalamic FTO, RPGRIP1L, and possibly other genes.

  11. FTO may have a deleterious role in hepatic cells during lipotoxic conditions, and up-regulation of FTO may contribute to the increased liver damage in non-alcoholic steatohepatitis

  12. Fto deficiency affects the gene and miR130/miR378 expression involved in brown adipogenesis and browning of white adipose tissue in mice.

  13. Here we show that FTO expression is increased after ureteral obstruction and renal fibrosis.

  14. Taken together, the results suggest that Fto regulates the proliferation and differentiation of 3T3-L1 cells via multiple mechanisms, including PPARgamma and PI3K/Akt signaling.

  15. These results reveal that FTO regulates fatty acid mobilization in adipocytes and thus body weight in part through posttranscriptional regulation of Angptl4.

  16. FTO-dependent N6-methyladenosine demethylation may be affected by betaine.

  17. FTO modulates circadian rhythms and inhibits the CLOCK-BMAL1-induced transcription.

  18. FTO expression and N6-methyladenosine levels are inversely correlated during adipogenesis. FTO depletion blocks differentiation and only catalytically active FTO restores adipogenesis.

  19. FTO is present in both the nucleus and cytoplasm, with a mobile fraction that shuttles between both cellular compartments, possibly by interaction with XPO2.

  20. FTO plays an important role in the development of metabolic disorders and is an interesting target for therapeutic agents.

Pig (Porcine) Fat Mass and Obesity-Associated (FTO) interaction partners

  1. Studied role of FTO alpha-ketoglutarate dependent dioxygenase (FTO) in adipogenesis of intramuscular adipocytes.

  2. In this study, the authors characterise the nucleotide variability and haplotype diversity of the porcine fat mass and obesity-associated (FTO) gene in breeds having different predispositions to fat deposition traits.

  3. In pig, the FTO gene influences back fat depth in the commercial populations.

  4. This study will provide clues for obtaining a better understanding of the porcine FTO gene function.

  5. The results of the association analyses confirmed the effect of the FTO mutation on obesity-related traits in the Italian Duroc pigs (P < 0.01) and in the commercial pigs.

  6. transcriptional levels in a range of different tissues under different physiological conditions, and physical mapping of gene

  7. The porcine fat mass and obesity associated (FTO) gene is associated with fat deposition in Italian Duroc pigs.

  8. Twelve variants including ten SNPs and two indels were detected, and then five SNPs within different genomic regions were genotyped in the ISU Berkshire x Yorkshire pig resource family.

Cow (Bovine) Fat Mass and Obesity-Associated (FTO) interaction partners

  1. 34 FTO polymorphisms revealed significant association of FTO variants with lean meat percentage in Simmental and Brown cattle breeds.

  2. association signals not only provided evidence for at least two causative mutations in the FTO locus with a functional effect on milk but also milk protein yield

  3. Haplotype frequencies and linkage disequilibrium (LD) coefficients of FTO single nucleotide polymorphisms in three Chinese indigenous cattle breeds were analyzed.

FTO Antigen Profile

Antigen Summary

This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes.

Gene names and symbols associated with FTO

  • FTO, alpha-ketoglutarate dependent dioxygenase (FTO) antibody
  • fat mass and obesity associated (Fto) antibody
  • FTO, alpha-ketoglutarate dependent dioxygenase (Fto) antibody
  • fat mass and obesity associated L homeolog (fto.L) antibody
  • AW743446 antibody
  • mKIAA1752 antibody
  • RGD1305121 antibody

Protein level used designations for FTO

alpha-ketoglutarate-dependent dioxygenase FTO , fat mass and obesity-associated protein , protein fto , protein fatso , fat mass and obesity associated protein , Protein fatso

GENE ID SPECIES
79068 Homo sapiens
26383 Mus musculus
478125 Canis lupus familiaris
100127165 Sus scrofa
291905 Rattus norvegicus
100060565 Equus caballus
618622 Bos taurus
100125353 Ovis aries
447305 Xenopus laevis
100173222 Pongo abelii
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