Fatty Acid Binding Protein 2, Intestinal Proteins (FABP2)

Zebrafish Fatty Acid Binding Protein 2, Intestinal (FABP2) interaction partners

1. In vivo experiments demonstrated, for the first time, that intestinal absorption of dietary BODIPY-FLC(12) was followed by colocalization of the labeled FA with Fabp1b and Fabp2 in the nuclei.

2. transcription of single copy fabp2 is modulated by dietary fatty acids and clofibrate in a tissue specific fashion.

3. Ifabp mRNAs were initially expressed in the zebrafish yolk syncytial layer at the ventral side during late epiboly (8-9 hpf), spread throughout the YSL of later stage embryos, and appeared in the intestine rudiment at approximately 36 hpf

4. analysis of conserved elements that mediate intestinal-type fatty acid binding protein (I-FABP) expression in the gut (show GUSB Proteins) epithelia of zebrafish larvae

5. dna analysis, linkage mapping and early developmental expression of the intestinal-type fatty acid-binding protein gene (fabp2) from zebrafish

Human Fatty Acid Binding Protein 2, Intestinal (FABP2) interaction partners

1. We found that polymorphic Arg16Gly in the ADRB2 (show ADRB2 Proteins) gene and Ala54Thr in the FABP2 gene had a discernible effect on the renal function in Chinese type 2 DN. Our data further revealed that homozygous Gly16 allele and Thr54 allele concomitantly conferred a significantly higher risk in the eGFR (show EGFR Proteins) reduction.

2. This study aimed to determine whether FABP2 (Ala54Thr) and MTTP (show MTTP Proteins) (-493 G/T) genetic polymorphisms are associated with metabolic disorders in Mexican subjects.

3. Data show that intestinal fatty acid binding protein (IFABP) is a promising prognostic marker in acute pancreatitis.

4. There was a positive correlation between FABP2 levels and BMI, SBP (show SHBG Proteins) and DBP (show GC Proteins), and a negative correlation with HDL (show HSD11B1 Proteins)-C. CONCLUSIONS: The Thr54 allele of the FABP2 Ala54Thr polymorphism was associated with an increased incidence of peripheral atherosclerosis combined with T2DM in the population studied

5. The FABP-2 gene is located on the long arm of chromosome 4, and encodes an intracellular protein (show CKAP2 Proteins) of the intestinal mucosa, responsible for the absorption and intracellular transport of fatty acids.

6. Enterocyte injury was common in critically ill patients with pneumonia. The severity of enterocyte injury, as evidenced by the urinary FABP2/creatinine, was associated with the patient's mortality.

7. Study reports that insulin (show INS Proteins) resistance-related gene polymorphisms effects colorectal cancer (CRC (show CALR Proteins)) risk. The results showed that the gene polymorphism of ADIPOQ rs2241766 was associated with CRC (show CALR Proteins) risk. Furthermore, the interactions of ADIPOQ rs2241766, UCP2 (show UCP2 Proteins) rs659366, FABP2 rs1799883 and red meat consumption may contribute to the risk of CRC (show CALR Proteins).

8. FTO (show FTO Proteins) and FABP2 gene polymorphisms were significantly associated with susceptibility to metabolic syndrome and obesity in this cohort.

9. Circulating I-FABP levels had no association with invasively-measured hemodynamic parameters, but were associated with adverse clinical outcomes in patients with acute decompensated heart failure with systolic dysfunction.

10. The aim of this study was to measure serum I-FABP levels and provide the transition of I-FABP levels with hypothermic circulatory arrest to help in the management of intestinal perfusion. Plasma I-FABP monitoring could be a valuable method for finding an intestinal ischemia in patients with cardiovascular surgery.

Pig (Porcine) Fatty Acid Binding Protein 2, Intestinal (FABP2) interaction partners

1. The full-length cDNA of I-FABP was cloned from intestine and the mRNA was extensively present in various tissues, but I-FABP transcript of approximately 620 bp was more abundant in intestine than in other tissues.

2. Plasma I-FABP concentration showed great variation within treatments, and no difference was observed in plasma I-FABP concentrations between the weaned conventionally and unweaned treatments

3. Association analyses of the FABP2:g.412T>C with fatty acid composition traits were not significant in simple association.

Mouse (Murine) Fatty Acid Binding Protein 2, Intestinal (FABP2) interaction partners

1. This direct comparison provides evidence that LFABP (show FABP1 Proteins) and IFABP have distinct roles in intestinal lipid metabolism; differential intracellular functions in intestine and in liver

2. detected the common as well as sex-differential pathways that are modified due to the loss of Fabp2. These findings suggest that the pathways involved in nutrient and xenobiotic metabolism in the intestine are regulated by sex-specific mechanisms

3. loss of I-FABP renders male mice sensitive to high fat diet-induced fatty liver, and this effect is independent of hepatic L-FABP