Fatty Acid Binding Protein 2, Intestinal Proteins (FABP2)

Zebrafish Fatty Acid Binding Protein 2, Intestinal (FABP2) interaction partners

1. In vivo experiments demonstrated, for the first time, that intestinal absorption of dietary BODIPY-FLC(12) was followed by colocalization of the labeled FA with Fabp1b and Fabp2 in the nuclei.

2. transcription of single copy fabp2 is modulated by dietary fatty acids and clofibrate in a tissue specific fashion.

3. Ifabp mRNAs were initially expressed in the zebrafish yolk syncytial layer at the ventral side during late epiboly (8-9 hpf), spread throughout the YSL of later stage embryos, and appeared in the intestine rudiment at approximately 36 hpf

4. analysis of conserved elements that mediate intestinal-type fatty acid binding protein (I-FABP) expression in the gut epithelia of zebrafish larvae

5. dna analysis, linkage mapping and early developmental expression of the intestinal-type fatty acid-binding protein gene (fabp2) from zebrafish

Human Fatty Acid Binding Protein 2, Intestinal (FABP2) interaction partners

1. Higher intestinal fatty acid binding protein (i-FABP) levels on admission were associated with pancreatic necrosis, systemic complications, and severe acute pancreatitis (AP).

2. serum level in newborns positively correlated with second stage of labor duration and active pushing time

3. We found that polymorphic Arg16Gly in the ADRB2 gene and Ala54Thr in the FABP2 gene had a discernible effect on the renal function in Chinese type 2 DN. Our data further revealed that homozygous Gly16 allele and Thr54 allele concomitantly conferred a significantly higher risk in the eGFR reduction.

4. This study aimed to determine whether FABP2 (Ala54Thr) and MTTP (-493 G/T) genetic polymorphisms are associated with metabolic disorders in Mexican subjects.

5. Data show that intestinal fatty acid binding protein (IFABP) is a promising prognostic marker in acute pancreatitis.

6. There was a positive correlation between FABP2 levels and BMI, SBP and DBP, and a negative correlation with HDL-C. CONCLUSIONS: The Thr54 allele of the FABP2 Ala54Thr polymorphism was associated with an increased incidence of peripheral atherosclerosis combined with T2DM in the population studied

7. The FABP-2 gene is located on the long arm of chromosome 4, and encodes an intracellular protein of the intestinal mucosa, responsible for the absorption and intracellular transport of fatty acids.

8. Enterocyte injury was common in critically ill patients with pneumonia. The severity of enterocyte injury, as evidenced by the urinary FABP2/creatinine, was associated with the patient's mortality.

9. Study reports that insulin resistance-related gene polymorphisms effects colorectal cancer (CRC) risk. The results showed that the gene polymorphism of ADIPOQ rs2241766 was associated with CRC risk. Furthermore, the interactions of ADIPOQ rs2241766, UCP2 rs659366, FABP2 rs1799883 and red meat consumption may contribute to the risk of CRC.

10. FTO and FABP2 gene polymorphisms were significantly associated with susceptibility to metabolic syndrome and obesity in this cohort.

11. Circulating I-FABP levels had no association with invasively-measured hemodynamic parameters, but were associated with adverse clinical outcomes in patients with acute decompensated heart failure with systolic dysfunction.

12. The aim of this study was to measure serum I-FABP levels and provide the transition of I-FABP levels with hypothermic circulatory arrest to help in the management of intestinal perfusion. Plasma I-FABP monitoring could be a valuable method for finding an intestinal ischemia in patients with cardiovascular surgery.

13. Urinary intestinal fatty acid-binding protein can distinguish necrotizing enterocolitis from sepsis in early stage of the disease.

14. I-FABP is a valid serologic biomarker for early diagnosis in NEC for the premature neonates with a moderate accuracy.

15. It is concluded that ACE (rs 4646994), FABP2 (rs1799883) and GST (GSTM1 null or positive genotype and GSTT1 null or positive genotype) genes polymorphism are associated with essential hypertension.

16. Ala54Thr polymorphism of FABP2 modulates HDL cholesterol in Mexican-Americans with type 2 diabetes.

17. Carriers of the Thr54 allele in FABP2 have a different metabolic response after weight loss than wild type non-A obese carriers

18. Letter: serum intestinal-fatty acid binding protein may serve as a biomarker for refractory celiac disease.

19. Ala54Thr polymorphism of FABP2 was associated with high triglycerides levels, but not to gallstone disease.

20. FABP2 Ala54Thr polymorphism may have a role in type 2 diabetes, obesity, and metabolic syndrome [case-control study and meta-analysis]

Pig (Porcine) Fatty Acid Binding Protein 2, Intestinal (FABP2) interaction partners

1. The full-length cDNA of I-FABP was cloned from intestine and the mRNA was extensively present in various tissues, but I-FABP transcript of approximately 620 bp was more abundant in intestine than in other tissues.

2. Plasma I-FABP concentration showed great variation within treatments, and no difference was observed in plasma I-FABP concentrations between the weaned conventionally and unweaned treatments

3. Association analyses of the FABP2:g.412T>C with fatty acid composition traits were not significant in simple association.

Mouse (Murine) Fatty Acid Binding Protein 2, Intestinal (FABP2) interaction partners

1. This direct comparison provides evidence that LFABP and IFABP have distinct roles in intestinal lipid metabolism; differential intracellular functions in intestine and in liver

2. detected the common as well as sex-differential pathways that are modified due to the loss of Fabp2. These findings suggest that the pathways involved in nutrient and xenobiotic metabolism in the intestine are regulated by sex-specific mechanisms

3. loss of I-FABP renders male mice sensitive to high fat diet-induced fatty liver, and this effect is independent of hepatic L-FABP