Fermitin Family Member 1 (FERMT1) ELISA Kits

FERMT1 encodes a member of the fermitin family, and contains a FERM domain and a pleckstrin homology domain. Additionally we are shipping FERMT1 Antibodies (51) and FERMT1 Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
FERMT1 55612 Q9BQL6
FERMT1 241639 P59113
Anti-Rat FERMT1 FERMT1 296179  
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Top FERMT1 ELISA Kits at antibodies-online.com

Showing 2 out of 7 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Mouse
  96 Tests Log in to see 2 to 3 Days
$867.90
Details
Human
  96 Tests Log in to see 11 to 18 Days
$653.82
Details

More ELISA Kits for FERMT1 Interaction Partners

Human Fermitin Family Member 1 (FERMT1) interaction partners

  1. Kindlin-1 is mainly expressed in the cytoplasm of normal esophageal squamous epithelium and Esophageal cancer (EC) cells. Kindlin-1 expression is positively correlated with tumor cell differentiation and is higher in stage I tumors. Kindlin-1 expression is higher in non-smoker patients than in smoker patients, and in patients with a family history of EC.

  2. Kindlin supports platelet GPIIB IIIA activation by interacting with paxillin.

  3. we demonstrated that Kindlin-1 promotes CRC progression by recruiting SARA and Smad3 to TbetaRI and thereby activates TGF-beta/Smad3 signaling. Thus, Kindlin-1 is a novel regulator of TGF-beta/Smad3 signaling and may also be a potential target for CRC therapeutics.

  4. Sequence analysis of KIND1 exons in patient 1 revealed a commonly reported homozygous nonsense mutation in exon 6 (c.811C>T;p.R271X). Both Patients 2 and 3 had novel homozygous single nucleotide deletions

  5. KS patients' periodontal disease activity could be taken under control with regular follow-up.

  6. these data define a novel role for Kin1 in microtubule acetylation and stability

  7. keratinocytes derived from KS patients are unable to undergo electrotaxis, and this defect is restored by overexpression of wild-type kindlin-1 but not a W612A mutation that prevents kindlin-integrin binding.

  8. FERMT1 activates the beta-catenin transcriptional activity to promote EMT in CC metastasis.

  9. KIND1 is important not only for keratinocyte proliferation but also for the suppression of UV-induced inflammation and DNA damage.

  10. We show a direct relationship between kindlin-1 abundance and UV-B induced apoptosis in keratinocytes, whereas kindlin-2 overexpression has no compensatory effect.

  11. These results indicate that Kindlin-1 is essential in EGF-induced re-epithelialization in skin wound healing and provide additional rationale for the clinical application of EGF in the treatment of acute wounds.

  12. KS is caused by mutations in the FERMT1 gene. Including the present, more than 60 mutations in FERMT1 have been identified since 2003. In spite of the expanding FERMT1 mutation database, there seems to be a lack of a clear genotype-phenotype correlation in KS

  13. A nonsense mutation in Exon 5 of KIND1 Gene in an Iranian Family may lead to incomplete and non-functional protein products and is pathogenic and has meaningful implications for the diagnosis of patients with Kindler syndrome.

  14. we show that a certain number of KS patients may harbor FERMT1 transcriptional regulatory mutations which are not routinely detected.

  15. Kindlin-1 is highly expressed in epithelial tissues derived from ectoderm and endoderm, whereas Kindlin-2 is mainly expressed in mesoderm-derived tissues. Likewise, Kindlin-1 was also found highly expressed in endoderm/ectoderm-derived tissues in embryos.

  16. FERMT1 mutation causing Kindler syndrome.

  17. our data suggest that Kindlin-1 could play an important role in hepatocellular carcinoma and might serve as a promising prognostic marker and potential target for hepatocellular carcinoma therapy.

  18. A spectrum of FERMT1 mutations in 13 Iranian families with a diagnosis of Kindler syndrome have been ascertained.

  19. We identified a novel mutation in FERMT1. These data are in agreement with the fact that the majority of KS-causing mutations in FERMT1 lead to premature termination of translation and to loss of kindlin-1 function in Kindler sysndrome

  20. C-terminal LIM domains of migfilin dictate its focal adhesion localization, and these domains mediate an interaction with kindlin in vitro and in cells, demonstrating that kindlin is important for normal migfilin dynamics.

Mouse (Murine) Fermitin Family Member 1 (FERMT1) interaction partners

  1. Kindin-1 is a critical mediator of early lung metastasis of breast cancer.

  2. Kindlin supports platelet GPIIB IIIA activation by interacting with paxillin.

  3. loss of Kindlin-1 leads to an imbalance in the cellular oxidative state, which renders Kindlin-1 deficient cells more prone to the effects of reactive oxygen species generated in response to oxidative stress

  4. these data define a novel role for Kin1 in microtubule acetylation and stability

  5. These results indicate that Kindlin-1 is essential in EGF-induced re-epithelialization in skin wound healing and provide additional rationale for the clinical application of EGF in the treatment of acute wounds.

  6. By modulating its affinity with kindlin, beta3 integrin may be able to locate near the cell edge where it can control beta1 integrin activation and clustering.

  7. Kindlin-1 is highly expressed in epithelial tissues derived from ectoderm and endoderm. Kindlin-1 was also found highly expressed in endoderm/ectoderm-derived tissues in embryos.

  8. Kindlin-1 controls keratinocyte adhesion through beta1-class integrins and proliferation and differentiation of cutaneous epithelial stem cells via TGF-beta activation and Wnt-beta-catenin signal inhibition.

  9. Kindlin-1 and Kindlin-2 have opposite roles in lung cancers

  10. The genomic organization, gene expression and subcellular localization of murine Kindlins-1 to -3, is described.

  11. Kindlin-1 in mice gives rise to skin atrophy and an intestinal epithelial dysfunction with similarities to human ulcerative colitis.

  12. Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects

Xenopus laevis Fermitin Family Member 1 (FERMT1) interaction partners

  1. Kindlin1 knockdown resulted in developmental delays, gross malformations of the gut and eventual lethality by tadpole stages.

Zebrafish Fermitin Family Member 1 (FERMT1) interaction partners

  1. The rof/kindlin-1 mutant zebrafish provides a unique model system to study epidermal adhesion mechanisms in vivo.

FERMT1 Antigen Profile

Antigen Summary

This gene encodes a member of the fermitin family, and contains a FERM domain and a pleckstrin homology domain. The encoded protein is involved in integrin signaling and linkage of the actin cytoskeleton to the extracellular matrix. Mutations in this gene have been linked to Kindler syndrome.

Gene names and symbols associated with FERMT1

  • fermitin family member 1 (FERMT1) antibody
  • fermitin family member 1 (Fermt1) antibody
  • fermitin family member 1 S homeolog (fermt1.S) antibody
  • fermitin family member 1 (fermt1) antibody
  • fermitin family homolog 1 (LOC100548276) antibody
  • 5830467P10Rik antibody
  • C20orf42 antibody
  • DTGCU2 antibody
  • KIND1 antibody
  • Kindlin-1 antibody
  • RGD1306816 antibody
  • si:ch73-22c10.1 antibody
  • UNC112A antibody
  • URP1 antibody
  • wu:fc32b07 antibody

Protein level used designations for FERMT1

UNC112 related protein 1 , fermitin family homolog 1 , kindlerin , kindlin 1 , kindlin syndrome protein , unc-112-related protein 1 , UNC-112 related protein 1 , fermitin family member 1 , fermitin family homolog 1-like , fc32b07

GENE ID SPECIES
55612 Homo sapiens
241639 Mus musculus
296179 Rattus norvegicus
379119 Xenopus laevis
458088 Pan troglodytes
485775 Canis lupus familiaris
524427 Bos taurus
718297 Macaca mulatta
100407542 Callithrix jacchus
416727 Gallus gallus
100332544 Danio rerio
100466357 Ailuropoda melanoleuca
100492800 Xenopus (Silurana) tropicalis
100548276 Meleagris gallopavo
100051761 Equus caballus
100157961 Sus scrofa
100732971 Cavia porcellus
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