Fermitin Family Member 1 (FERMT1) ELISA Kits

FERMT1 encodes a member of the fermitin family, and contains a FERM domain and a pleckstrin homology domain.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human FERMT1 FERMT1 55612 Q9BQL6
Anti-Mouse FERMT1 FERMT1 241639 P59113
Anti-Rat FERMT1 FERMT1 296179  
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Top FERMT1 ELISA Kits at antibodies-online.com

Showing 2 out of 6 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Mouse 78-5000 pg/mL   96 Tests Log in to see 2 to 3 Days
$867.90
Details
Human
  96 Tests Log in to see 15 to 18 Days
$1,029.60
Details

More ELISA Kits for FERMT1 Interaction Partners

Human Fermitin Family Member 1 (FERMT1) interaction partners

  1. Kindlin supports platelet GPIIB IIIA activation by interacting with paxillin (show PXN ELISA Kits).

  2. we demonstrated that Kindlin-1 promotes CRC (show CALR ELISA Kits) progression by recruiting SARA (show ZFYVE9 ELISA Kits) and Smad3 (show SMAD3 ELISA Kits) to TbetaRI (show TGFBR1 ELISA Kits) and thereby activates TGF-beta (show TGFB1 ELISA Kits)/Smad3 (show SMAD3 ELISA Kits) signaling. Thus, Kindlin-1 is a novel regulator of TGF-beta (show TGFB1 ELISA Kits)/Smad3 (show SMAD3 ELISA Kits) signaling and may also be a potential target for CRC (show CALR ELISA Kits) therapeutics.

  3. Sequence analysis of KIND1 exons in patient 1 revealed a commonly reported homozygous nonsense mutation in exon 6 (c.811C>T;p.R271X). Both Patients 2 and 3 had novel homozygous single nucleotide deletions

  4. these data define a novel role for Kin1 in microtubule acetylation and stability

  5. keratinocytes derived from KS patients are unable to undergo electrotaxis, and this defect is restored by overexpression of wild-type kindlin-1 but not a W612A mutation that prevents kindlin-integrin binding.

  6. FERMT1 activates the beta-catenin (show CTNNB1 ELISA Kits) transcriptional activity to promote EMT (show ITK ELISA Kits) in CC metastasis.

  7. KIND1 is important not only for keratinocyte proliferation but also for the suppression of UV-induced inflammation and DNA damage.

  8. We show a direct relationship between kindlin-1 abundance and UV-B induced apoptosis in keratinocytes, whereas kindlin-2 (show FERMT2 ELISA Kits) overexpression has no compensatory effect.

  9. These results indicate that Kindlin-1 is essential in EGF (show EGF ELISA Kits)-induced re-epithelialization in skin wound healing and provide additional rationale for the clinical application of EGF (show EGF ELISA Kits) in the treatment of acute wounds.

  10. KS is caused by mutations in the FERMT1 gene. Including the present, more than 60 mutations in FERMT1 have been identified since 2003. In spite of the expanding FERMT1 mutation database, there seems to be a lack of a clear genotype-phenotype correlation in KS

Mouse (Murine) Fermitin Family Member 1 (FERMT1) interaction partners

  1. Kindlin supports platelet GPIIB IIIA activation by interacting with paxillin (show PXN ELISA Kits).

  2. loss of Kindlin-1 leads to an imbalance in the cellular oxidative state, which renders Kindlin-1 deficient cells more prone to the effects of reactive oxygen species generated in response to oxidative stress

  3. these data define a novel role for Kin1 in microtubule acetylation and stability

  4. These results indicate that Kindlin-1 is essential in EGF (show EGF ELISA Kits)-induced re-epithelialization in skin wound healing and provide additional rationale for the clinical application of EGF (show EGF ELISA Kits) in the treatment of acute wounds.

  5. By modulating its affinity with kindlin, beta3 integrin (show ITGB3 ELISA Kits) may be able to locate near the cell edge where it can control beta1 integrin activation and clustering.

  6. Kindlin-1 is highly expressed in epithelial tissues derived from ectoderm and endoderm. Kindlin-1 was also found highly expressed in endoderm/ectoderm-derived tissues in embryos.

  7. Kindlin-1 controls keratinocyte adhesion through beta1-class integrins and proliferation and differentiation of cutaneous epithelial stem cells via TGF-beta (show TGFB1 ELISA Kits) activation and Wnt (show WNT2 ELISA Kits)-beta-catenin (show CTNNB1 ELISA Kits) signal inhibition.

  8. Kindlin-1 and Kindlin-2 (show FERMT2 ELISA Kits) have opposite roles in lung cancers

  9. Kindlin-1 in mice gives rise to skin atrophy and an intestinal epithelial dysfunction with similarities to human ulcerative colitis.

  10. Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects

Xenopus laevis Fermitin Family Member 1 (FERMT1) interaction partners

  1. Kindlin1 knockdown resulted in developmental delays, gross malformations of the gut (show GUSB ELISA Kits) and eventual lethality by tadpole stages.

Zebrafish Fermitin Family Member 1 (FERMT1) interaction partners

  1. The rof/kindlin-1 mutant zebrafish provides a unique model system to study epidermal adhesion mechanisms in vivo.

FERMT1 Antigen Profile

Antigen Summary

This gene encodes a member of the fermitin family, and contains a FERM domain and a pleckstrin homology domain. The encoded protein is involved in integrin signaling and linkage of the actin cytoskeleton to the extracellular matrix. Mutations in this gene have been linked to Kindler syndrome.

Gene names and symbols associated with FERMT1

  • fermitin family member 1 (FERMT1) antibody
  • fermitin family member 1 (Fermt1) antibody
  • fermitin family member 1 S homeolog (fermt1.S) antibody
  • fermitin family member 1 (fermt1) antibody
  • fermitin family homolog 1 (LOC100548276) antibody
  • 5830467P10Rik antibody
  • C20orf42 antibody
  • DTGCU2 antibody
  • KIND1 antibody
  • Kindlin-1 antibody
  • RGD1306816 antibody
  • si:ch73-22c10.1 antibody
  • UNC112A antibody
  • URP1 antibody
  • wu:fc32b07 antibody

Protein level used designations for FERMT1

UNC112 related protein 1 , fermitin family homolog 1 , kindlerin , kindlin 1 , kindlin syndrome protein , unc-112-related protein 1 , UNC-112 related protein 1 , fermitin family member 1 , fermitin family homolog 1-like , fc32b07

GENE ID SPECIES
55612 Homo sapiens
241639 Mus musculus
296179 Rattus norvegicus
379119 Xenopus laevis
458088 Pan troglodytes
485775 Canis lupus familiaris
524427 Bos taurus
718297 Macaca mulatta
100407542 Callithrix jacchus
416727 Gallus gallus
100332544 Danio rerio
100466357 Ailuropoda melanoleuca
100492800 Xenopus (Silurana) tropicalis
100548276 Meleagris gallopavo
100051761 Equus caballus
100157961 Sus scrofa
100732971 Cavia porcellus
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