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The protein encoded by FRS3 is a substrate for the fibroblast growth factor receptor. Additionally we are shipping Fibroblast Growth Factor Receptor Substrate 3 Antibodies (54) and Fibroblast Growth Factor Receptor Substrate 3 Kits (19) and many more products for this protein.
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signaling via Pax6 expression through Shp2-binding sites of XFrs3 is necessary for the eye development in Xenopus laevis
Mechanisms by which FRS2beta acts as a feedback inhibitor of EGFR family members and suggest a role for FRS2beta as a tumor suppressor.
an FRS2beta-CIN85/CD2AP-Cbl axis for downregulation of ErbB2 may regulate ErbB2 protein levels in physiological and pathological settings
FRS2 PTB domain conformation regulates interactions with divergent neurotrophic receptors
FRS2beta can compensate for the loss of FRS2alpha for activation of MAP kinase when expressed in fibroblasts
SNT-2 negatively regulates ERK2 signaling activated via EGF stimulation through direct binding to ERK2
Novel mechanism of negative control of EGFR tyrosine kinase activity with SNT-2 by recruiting ERK2.
FRS2 and FRS3, are together required for postnatal brain development. In the hippocampus, FRS2&3 promote dentate gyrus morphogenesis and dentate granule cell (DGC) maturation during developmental neurogenesis. Frs2,3-double mutants have reduced numbers of dendritic branches and spines in DGCs. Double-mutant mice exhibit fewer excitatory synaptic inputs onto DGCs.
Analysis of a mutant Fgfr1 allele, unable to bind to the adaptor protein, Frs2/3, indicates that Sox2 maintenance can be
data indicate that the fibroblast growth factor receptor substrate 2 and fibroblast growth factor receptor substrate 3 adapters may have a role in thyroid carcinogenesis triggered by TRK oncogenes
Some essential functions of Fgfr1 are mediated by Frs-independent signaling.
ULK2, by interaction with FRS2/3 and inhibition of SynGAP, functions to negatively regulate tyrosyl phosphorylation of signaling proteins downstream of FGFR1.
SNT family proteins may play significant roles in cellular transformation triggered by NPM-ALK.
The results showed that the interaction of full-length FRS2beta with FGFR1 was not enhanced by activation of the receptor kinase.
Prominent expression of Frs2beta protein in neural cells and its association with intracellular vesicles is reported.
The protein encoded by this gene is a substrate for the fibroblast growth factor receptor. It is found in peripheral plasma membrane and functions in linking FGF receptor stimulation to activators of Ras.
fibroblast growth factor receptor substrate 3
, FGFR substrate 3
, FGFR-signaling adaptor SNT2
, suc1-associated neurotrophic factor target 2 (FGFR signalling adaptor)
, suc1-associated neurotrophic factor target 2