FMO3 Proteins

Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds.

Data Quality
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    Protein
Antigen
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Reactivity
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Application
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Host
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Binding Specificity
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Conjugate
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6 Products
Recombinant Protein, Insect Cells (Source), Purity >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivityHuman
Application Crys, ELISA, SDS, WB
Order details Cat. No. ABIN3080250
$9,371.15
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 60 Business Days
Recombinant Protein, Insect Cells (Source), Purity >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivityMouse (Murine)
Application Crys, ELISA, SDS, WB
Order details Cat. No. ABIN3121222
$9,371.15
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 60 Business Days
ReactivityHuman
Application AA, AP, ELISA, WB
Order details Cat. No. ABIN1354250
$230.67
2 μg
Plus shipping costs $45.00 and $22.00 dry ice
Delivery in 11 to 12 Business Days
Recombinant Protein, HEK-293 Cells (Source), Purity > 80 % as determined by SDS-PAGE and Coomassie blue staining
ReactivityHuman
Application AbP, Func, PI, STD
Order details Cat. No. ABIN2721250
$888.80
20 μg
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 11 Business Days
Recombinant Protein, HEK-293 Cells (Source), Purity > 80 % as determined by SDS-PAGE and Coomassie blue staining
ReactivityHuman
Application AbP, Func, PI, STD
Order details Cat. No. ABIN2721249
$932.80
20 μg
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 11 Business Days
Recombinant Protein, Yeast (Source), Purity > 90 %
ReactivityRat (Rattus)
Application ELISA
Order details Cat. No. ABIN1652026
$3,510.83
1 mg
Plus shipping costs $45.00
Delivery in 60 to 71 Business Days
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FMO3 Protein Profile

Protein Summary

Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.

Gene names and symbols associated with FMO3

  • flavin containing monooxygenase 3 (FMO3) antibody
  • flavin containing monooxygenase 3 (fmo3) antibody
  • flavin containing monooxygenase 3 L homeolog (fmo3.L) antibody
  • flavin containing monooxygenase 3 (Fmo3) antibody
  • AW111792 antibody
  • dJ127D3.1 antibody
  • FM03 antibody
  • FMOII antibody
  • MGC107820 antibody
  • TMAU antibody

Protein level used designations for FMO3

dimethylaniline monooxygenase [N-oxide-forming] 3 , flavin containing monooxygenase 3 , FMO 3 , FMO II , FMO form 2 , dimethylaniline oxidase 3 , hepatic flavin-containing monooxygenase 3 , hepatic flavin-containing monooxygenase-3 , trimethylamine monooxygenase , flavin-containing monooxygenase 3 , FMO 1D1 , flavin-containing monooxygenase FMO3 , flavin-containing monooxygenase form 3

GENE ID SPECIES
100171678 Pongo abelii
548424 Xenopus (Silurana) tropicalis
447265 Xenopus laevis
2328 Homo sapiens
403603 Canis lupus familiaris
281167 Bos taurus
100009065 Oryctolagus cuniculus
14262 Mus musculus
84493 Rattus norvegicus
457505 Pan troglodytes
574244 Macaca mulatta
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