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May be involved in energy and/or nutrient sensing (By similarity). Additionally we are shipping and and many more products for this protein.
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Human Polyclonal FNIP1 Primary Antibody for ELISA - ABIN548186
Baba, Hong, Sharma, Warren, Nickerson, Iwamatsu, Esposito, Gillette, Hopkins, Hartley, Furihata, Oishi, Zhen, Burke, Linehan, Schmidt, Zbar: Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling. in Proceedings of the National Academy of Sciences of the United States of America 2006
The FLCN-FNIP complex deregulated in Birt-Hogg-Dube syndrome is absolutely required for B-cell differentiation.
Results suggest that FLCN, mutated in Birt-Hogg-Dube syndrome, and its interacting partner FNIP1 may be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways.
Loss of Fnip1 alters kidney developmental transcriptional program and synergizes with TSC1 loss to promote mTORC1 activation and renal cyst formation
These findings suggest that Dihydromyricetin treatment prevents palmitate-induced slow-twitch fibers decrease partially via FLCN-FNIP1-AMPK pathway thereby improving insulin resistance in obesity.
FNIP1-deficient mice developed cardiomyopathy characterized by left ventricular hypertrophy and glycogen accumulation.
Mechanistically, miR-499 directly targets Fnip1, an AMP-activated protein kinase (AMPK)-interacting protein that negatively regulates AMPK, a known activator of PGC-1alpha. This miR-499/Fnip1/AMPK circuit can serve as a mechanism to couple muscle fiber type and mitochondrial function.
Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn
loss of Fnip1 increased the representation of type I fibers characterized by increased myoglobin, slow twitch markers [myosin heavy chain 7, succinate dehydrogenase, troponin I 1, troponin C1, troponin T1], capillary density, and mitochondria number
These results indicate that Fnip1 is vital for invariant natural killer cell development by maintaining metabolic homeostasis in response to metabolic stress.
May be involved in energy and/or nutrient sensing (By similarity).
folliculin interacting protein 1
, folliculin-interacting protein 1-like
, folliculin-interacting protein 1