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May be involved in energy and/or nutrient sensing (By similarity). Additionally we are shipping and many more products for this protein.
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Human Polyclonal FNIP1 Primary Antibody for ELISA - ABIN408659
Baba, Hong, Sharma, Warren, Nickerson, Iwamatsu, Esposito, Gillette, Hopkins, Hartley, Furihata, Oishi, Zhen, Burke, Linehan, Schmidt, Zbar: Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling. in Proceedings of the National Academy of Sciences of the United States of America 2006
The FLCN (show FLCN Antibodies)-FNIP complex deregulated in Birt-Hogg-Dube syndrome is absolutely required for B-cell differentiation.
Results suggest that FLCN (show FLCN Antibodies), mutated in Birt-Hogg-Dube syndrome, and its interacting partner FNIP1 may be involved in energy and/or nutrient sensing through the AMPK (show PRKAA1 Antibodies) and mTOR (show FRAP1 Antibodies) signaling pathways.
FNIP1-deficient mice developed cardiomyopathy characterized by left ventricular hypertrophy and glycogen (show GYS1 Antibodies) accumulation.
Mechanistically, miR (show MLXIP Antibodies)-499 directly targets Fnip1, an AMP-activated protein kinase (AMPK (show PRKAA2 Antibodies))-interacting protein that negatively regulates AMPK (show PRKAA1 Antibodies), a known activator of PGC-1alpha (show PPARGC1A Antibodies). This miR (show MLXIP Antibodies)-499/Fnip1/AMPK (show PRKAA1 Antibodies) circuit can serve as a mechanism to couple muscle fiber type and mitochondrial function.
Fnip1 and Fnip2 (show FNIP2 Antibodies) play critical roles in kidney tumor suppression in cooperation with Flcn (show FLCN Antibodies)
loss of Fnip1 increased the representation of type I fibers characterized by increased myoglobin, slow twitch markers [myosin heavy chain 7, succinate dehydrogenase, troponin I 1, troponin C1, troponin T1], capillary density, and mitochondria number
These results indicate that Fnip1 is vital for invariant natural killer cell development by maintaining metabolic homeostasis in response to metabolic stress.
May be involved in energy and/or nutrient sensing (By similarity).
folliculin interacting protein 1
, folliculin-interacting protein 1-like
, folliculin-interacting protein 1