anti-Fras1 Related Extracellular Matrix Protein 2 (FREM2) Antibodies

FREM2 encodes a membrane protein that belongs to the FRAS1 family.

list all antibodies Gene Name GeneID UniProt
FREM2 341640 Q5SZK8
FREM2 242022 Q6NVD0
FREM2 310418  
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Top anti-FREM2 Antibodies at antibodies-online.com

Showing 10 out of 29 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Please inquire Goat Un-conjugated ELISA   100 μg 6 to 7 Days
$291.53
Details
Human Rabbit Un-conjugated ELISA, ICC, IHC, IHC (p), WB Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg 11 to 14 Days
$616.00
Details
Human Goat Un-conjugated ELISA   0.1 mg 2 to 3 Days
$446.88
Details
Human Rabbit Un-conjugated EIA, IF, WB   0.1 mg 4 to 8 Days
$522.50
Details
Cow Goat Un-conjugated ELISA   100 μg 11 to 14 Days
$507.83
Details
Human Rabbit Un-conjugated ICC, IHC (p), ELISA, WB 50 μg 12 to 14 Days
$686.14
Details
Human Rabbit Un-conjugated EIA, IF, IHC (p), WB Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg 6 to 8 Days
$495.00
Details
Human Rabbit Un-conjugated ELISA, FM, WB Immunofluorescence of FREM2 Antibody Immunofluorescence Microscopy of FREM2 antibody. Tissue: A20 cells. Fixation: 0.5% PFA. Antigen retrieval: not required. Primary antibody: FREM2 antibody at 20 µg/mL for 1 h at RT. Secondary antibody: Fluorescein rabbit secondary antibody at 1:10,000 for 45 min at RT. Localization: FREM2 is a membrane protein. Staining: FREM2 as red fluorescent signal. Immunocytochemistry of FREM2 Antibody Immunocytochemistry of FREM2 antibody. Tissue: A20 cells. Fixation: formalin fixed paraffin embedded. Antigen retrieval: not required. Primary antibody: FREM2 antibody at 20 µg/mL for 1 h at RT. Secondary antibody: Peroxidase rabbit secondary antibody at 1:10,000 for 45 min at RT. Localization: FREM2 is a membrane protein. Staining: FREM2 as precipitated blue signal with pink nuclear counterstain. 100 μg 1 to 2 Days
$394.90
Details
Human Rabbit Un-conjugated ELISA, ICC, WB Immunocytochemistry of A-20 cells with FREM2 polyclonal antibody  at 20 ug/mL. Western blot analysis of FREM2 in A-20 cell lysate with FREM2 polyclonal antibody  at (1) 0.5 and (2) 1ug/mL. 100 μg 11 to 12 Days
$356.00
Details
Human Rabbit Un-conjugated IHC (p) Immunohistochemical staining of human heart muscle with FREM2 polyclonal antibody  shows strong cytoplasmic positivity in myocytes at 1:10-1:20 dilution. 100 μL 11 to 12 Days
$577.33
Details

More Antibodies against FREM2 Interaction Partners

Human Fras1 Related Extracellular Matrix Protein 2 (FREM2) interaction partners

  1. Based on these data, we conclude that deficiency of FREM2, and possibly FRAS1, are associated with an increased risk of developing Congenital diaphragmatic hernia (CDH) and that loss of the FREM1/FREM2/FRAS1 complex, or its function, leads to anterior sac CDH development through its effects on mesothelial fold progression

  2. Our results showed that p.Arg2167Trp had a weaker effect in interrupting interactions between FREM2 and FREM1 than FS-associated missense mutation p.Glu1972Lys. Overall, our data demonstrate that the homozygous mutation p.Arg2167Trp in FREM2 causes isolated Cryptophthalmos(CO), which will facilitate our better understanding of the molecular mechanisms underlying the disease

  3. FREM2 is thus proposed as a novel GB biomarker and a putative biomarker of glioblastoma stem cells. Both FREM2 and SPRY1 are expressed on the surface of the GB cells, while SPRY1 alone was found overexpressed in the cytosol of non-malignant astrocytes.

  4. In 15 of 590 families, we identified recessive mutations in the genes FRAS1, FREM2, GRIP1, FREM1, ITGA8, and GREM1, all of which function in the interaction of the ureteric bud and the metanephric mesenchyme.

  5. Amplification of the FREM2 gene is associated with mesenchymal differentiation in gliosarcoma.

  6. Heterozygous missense mutations in FREM2 cause non-syndromic congenital abnormalities of the kidney and urinary tract in humans.

  7. report on 2 fetuses affected by Fraser syndrome (FS); a homozygous IVS14 + 1G -- A mutation in FREM2 was indentified; present report provides additional evidence that FS may be caused by complete or near-complete lack or loss of function of FREM2 protein

  8. 1 new mutation in FREM2 was identified in families with Fraser syndrome.

Mouse (Murine) Fras1 Related Extracellular Matrix Protein 2 (FREM2) interaction partners

  1. Report Fras1 up-regulation/Frem down-regulation in nephrons from mice with polycystic kidney disease and Frem2 mutations.

  2. The QBRICK, together with Frem2, defines the ability of BMs to bind integrin 81 through modulating the BM assembly of nephronectin, thereby regulating the integrin 81-mediated signals transmitted from the ureteric buds to the metanephric mesenchyme.

  3. expression of Frem2 may dynamically alter the extracellular matrix to provide a substrate for cell migration and rearrangements during embryogenesis

  4. QBRICK/Frem1, Fras1, and Frem2 interactions at the basement membrane have roles in preventing Fraser syndrome-like defects

  5. Study reports a comparative analysis of the spatiotemporal localization of Fras1, Frem1, Frem2 and Frem3 proteins during mouse embryonic development.

  6. Fras1 is not only essential as a component of a macromolecular complex for the extracellular stabilization of Frem2 but it is also required for its proper intracellular trafficking and export from embryonic epithelial cells.

  7. The localization pattern of Fras1 and Frem2 was indistinguishable, while both proteins along with Frem3 could be detected even in the absence of Frem1.

FREM2 Antigen Profile

Protein Summary

This gene encodes a membrane protein that belongs to the FRAS1 family. This extracellular matrix protein is thought to be required for maintaining the integrity of the skin epithelium and the differentiated state of renal epithelia. The protein localizes to the basement membrane, forming a ternary complex that plays a role in epidermal-dermal interactions during morphogenetic processes. Mutations in this gene are associated with Fraser syndrome.

Gene names and symbols associated with FREM2

  • FRAS1 related extracellular matrix protein 2 (FREM2) antibody
  • Fras1 related extracellular matrix protein 2 (Frem2) antibody
  • 6030440P17Rik antibody
  • 8430406N05Rik antibody
  • b2b1562Clo antibody
  • Gm409 antibody
  • my antibody
  • ne antibody
  • nv1 antibody
  • RGD1566012 antibody

Protein level used designations for FREM2

ECM3 homolog , FRAS1-related extracellular matrix protein 2 , NV domain containing protein NV1 , NV domain-containing protein 1

GENE ID SPECIES
341640 Homo sapiens
242022 Mus musculus
310418 Rattus norvegicus
486002 Canis lupus familiaris
527601 Bos taurus
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