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Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production.. Additionally we are shipping and many more products for this protein.
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GPR4 (show GPR4 Antibodies) blockade attenuated renal injury after IR and reduced the cell apoptosis through the suppression of CHOP (show DDIT3 Antibodies) expression.
GPR19 overexpression drives MDA-MB-231 cells towards an epithelial phenotype. GPR19 upregulates E-cadherin (show CDH1 Antibodies) via MAPK (show MAPK1 Antibodies)/ERK1/2 (show MAPK1/3 Antibodies) pathway.
acidosis/GPR4 (show GPR4 Antibodies)-induced endoplasmic reticulum stress pathways in endothelial cells may regulate vascular growth and inflammatory response in the acidic microenvironment.
it was demonstrated that GPR4 (show GPR4 Antibodies) affects ECs by regulating Notch1 (show NOTCH1 Antibodies), a function that may be important for physiological and pathological angiogenesis.
GPR4 (show GPR4 Antibodies) induces angiogenesis via GPR4 (show GPR4 Antibodies)-induced p38 (show CRK Antibodies)-mediated IL6 (show IL6 Antibodies), IL8 (show IL8 Antibodies) and VEGFA (show VEGFA Antibodies) secretion at acidic extracellular pH in squamous cell carcinoma of the head and neck
The results suggested that GPR4 (show GPR4 Antibodies) may play an important role in the development of epithelial ovarian carcinoma (EOC), and its overexpression might be required for the angiogenesis, tumor growth, and metastasis of EOC
G protein-coupled receptor 19 (GPR19) was found frequently overexpressed in tissue samples obtained from patients with small cell lung cancer.
acidosis/GPR4 (show GPR4 Antibodies) signaling regulates endothelial cell adhesion mainly through the G(s)/cAMP/Epac (show RAPGEF3 Antibodies) pathway
The mutation of histidine residue at 79, 165, or 269 from the N-terminal of GPR4 (show GPR4 Antibodies) to phenylalanine shifted the half-maximal effective concentration (EC(50)) of proton-induced signaling activities to the right, including cAMP accumulation.
Endogenous GPR4 (show GPR4 Antibodies) in endothelial cells may be a potential G protein-coupled receptor (show ADRA1A Antibodies) by which LPC (show PCSK7 Antibodies) signals proinflammatory activities.
orphan G-protein coupled receptor, similar to D2 dopamine and adrenergic receptors
, probable G-protein coupled receptor 19
, G protein-coupled receptor 19