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The protein encoded by GEM belongs to the RAD/GEM family of GTP-binding proteins.
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High Geminin (show GMNN ELISA Kits) expression is associated with triple negative breast cancers.
these data identify DUB3 and USP7 as factors that regulate DNA replication by controlling Geminin protein (show GMNN ELISA Kits) stability, and suggest that USP7 may be involved in Geminin (show GMNN ELISA Kits) dysregulation during breast cancer progression.
geminin selectively couples the transcription factor forkhead box O3 (FoxO3) to HDAC3, thereby specifically facilitating FoxO3 deacetylation.
summarize current information on the molecular functions of Geminin (show GMNN ELISA Kits) and the regulatory system for Geminin protein (show GMNN ELISA Kits) expression, and argue for the molecular role of Geminin (show GMNN ELISA Kits) in cell fate determination of hematopoietic stem cells [review]
Down regulation of Gem expression was involved in the pathogenesis of hepatocellular carcinoma (HCC), and it might be a favorable independent prognostic parameter for HCC.
Studies indicate that geminin (show GMNN ELISA Kits) expression is associated with different types of cancer.
High geminin (show GMNN ELISA Kits) expression is associated with breast cancer.
De novo GMNN (show GMNN ELISA Kits) mutations cause autosomal-dominant primordial dwarfism associated with Meier-Gorlin syndrome.
Elevated Ki67 (show MKI67 ELISA Kits) and geminin (show GMNN ELISA Kits) expression distinguish a fraction of metastatic breast carcinoma with worse prognosis.
These findings demonstrate a new role of Gem/Gmip/RhoA signaling in cortical actin regulation during early mitotic stages.
Rad, Gem and Rem all reduce depolarization-dependent Ca2 (show CA2 ELISA Kits)+ entry in developing myotubes.
These results suggest that Gem plays an important role in normal beta-cell function by regulation of calcium signalling.
Mechanism of the inhibition of calcium channel activity by Gem.
docking of the RGK protein to the nucleotide-kinase domain of the Cavbeta subunit is reminiscent of the binding of GMP (show NT5C2 ELISA Kits) to guanylate kinase (show GUK1 ELISA Kits)
Results identify specific nuclear localization signals (NLS (show ALDH1A2 ELISA Kits)) in Kir/Gem that are both required and sufficient for nuclear transport.
This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16.
GTP-binding mitogen-induced T-cell protein
, GTP-binding protein GEM
, GTP-binding protein overexpressed in skeletal muscle
, RAS-like protein KIR
, kinase-inducible Ras-like protein
, GTP binding protein overexpressed in skeletal muscle
, Gem GTPase
, GTP binding protein gene overexpressed in skeletal muscle
, GTP binding protein (gene overexpressed in skeletal muscle)