Gap Junction Protein, delta 2, 36kDa Proteins (GJD2)

GJD2 encodes a member of the connexin protein family. Additionally we are shipping Gap Junction Protein, delta 2, 36kDa Antibodies (71) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GJD2 57369 Q9UKL4
GJD2 14617 O54851
Rat GJD2 GJD2 50564 O70610
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Top Gap Junction Protein, delta 2, 36kDa Proteins at

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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days

GJD2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for Gap Junction Protein, delta 2, 36kDa (GJD2) Interaction Partners

Human Gap Junction Protein, delta 2, 36kDa (GJD2) interaction partners

  1. a possible contribution of connexin 36 to amyotrophic lateral sclerosis pathogenesis

  2. Our findings suggest that the stimulatory effect of hexanol and isoflurane on Cx36 gap junction conductance could be achieved by re-shuffling of the inter-subunit disulphide bond between C264 and C92 to the intra-subunit one between C264 and C87.

  3. Our studies have shown that the heritability of myopia makes 66.4% in Lithuania. We detected significant associations between the combinations of GJD2 CC and RASGRF1 GT and odds ratio of developing myopia.

  4. Study shows that human outer retina displays a diverse cohort of connexin 36 gap junctions that follows the general mammalian scheme and display a great functional diversity.

  5. Sparse punctate Cx36 expression was seen in the myenteric plexus in nerve trunks and some platelet-derived growth factor receptor-alpha-positive cell and interstitial cells of Cajal fibers in patients with Hirschsprung's disease.

  6. Genetic variants in ZC3H11B, RSPO1, and GJD2 are associated with susceptibility to the development of high myopia in a Han Chinese population.

  7. It was shown that the decreased level of the examined neuronal proteins was accompanied by the impaired coexpression of synaptophysin/neurofilaments and Cx36 in the series of astrocytomas--anaplastic astrocytomas--glioblastomas.

  8. In this study, there was no association of the analyzed SNPs located in RASGRF1. GJD2, and ACTC1 with pathological myopia.

  9. Three SNP alleles in BRD2, Cx-36, and ME2 and microdeletions in 15q13.3, 15q11.2, and 16p13.11 also contribute risk to juvenile myclonic epilepsy.

  10. Cx36 GJs are highly cation-selective and should exhibit relatively low permeability to numerous vital negatively charged metabolites and high permeability to potassium ion, a major charge carrier in cell-cell communication.

  11. A polymorphism of Cx36 gene is associated to certain forms of human diabetes

  12. connexin genes Gjd2 coding for mCx36, Gjc1 coding for mCx45 and Gja10 coding for mCx57 in the mouse, a subset of 4 connexin genes, including the unique GJA9 (Cx59) and GJA10 (Cx62), could be detected at least as transcript isoforms in the human retina.

  13. Variations in GJD2 is associated with refractive errors and myopia.

  14. Mutations in the calcium-binding motifs of CDH23 and the 35delG mutation in GJB2 cause hearing loss in one family

  15. connexin 36 expression is regulated by the transcriptional repressor NRSF/REST

  16. 35delG mutation of the GJB2 gne is a risk for deafness

  17. Results of reporter gene analysis of Cx36 expression in transgenic mice suggest that Cx36 has functional roles not only in several types of neurons in the retina and central nervous system but also in excitable cells of the pancreas and adrenal gland.

  18. significant association between juvenile myoclonic epilepsy and a Polymorphism, Single Nucleotide within exon 2 of CX36.

  19. Intercellular coupling occurs between neuronal and microglial populations through Cx36 gap junctions; This has important implications for normal neural physiology and microglial responses in neuronopathology in the mammalian CNS.

  20. The present results provide confirmatory evidence for an allelic and genotypic association of the CX36 gene with juvenile myoclonic epilepsy.

Cow (Bovine) Gap Junction Protein, delta 2, 36kDa (GJD2) interaction partners

  1. Interneuronal communication at gap junctions made by connexin 36 may not be regulated by direct phosphorylation of connexin 36, but possibly by phosphorylation of associated proteins.

Rabbit Gap Junction Protein, delta 2, 36kDa (GJD2) interaction partners

  1. Study suggests that Cx36 (GJD2) expression in the AII-mediated rod pathway is activity dependent in the developing rabbit retina

Mouse (Murine) Gap Junction Protein, delta 2, 36kDa (GJD2) interaction partners

  1. The increased Cx36 immunopositive product in mossy fibers at the chronic stage after PISE may enhance the contacts between granule cells in the dentate gyrus and pyramidal neurons in CA3 area.

  2. data suggest a possible contribution of Cx36 to ALS pathogenesis amyotrophic lateral sclerosis

  3. Results indicate that even though Cx36 may be required for electrical coupling of suprachiasmatic nucleus cells, it does not affect coupling of molecular clock gene rhythms. Thus, electrical coupling of neurons and coupling of circadian clock gene oscillations can be regulated independently in the suprachiasmatic nucleus.

  4. In mice, strain differences were found, such that punctate labelling for Cx36 was differentially distributed in the molecular layer of C57BL/6 vs. CD1 mice. Cx36-puncta were localized to processes of stellate cells and other cerebellar interneurons. The vast majority of Cx36-puncta co-localized with Cx45-puncta, which in turn was associated with the scaffolding protein zonula occludens-1.

  5. Cx36 deletion therefore disrupts normal regulation of sympathetic outflow with effects on cardiovascular parameters.

  6. Deletion of connexin 36 increased the frequency and shifted the amplitude distributions of miniature inhibitory post synaptic potentials.

  7. retinal aberrant activity was reduced in the rd10/Cx36KO mice compared to rd10 controls, a direct evidence for involvement of Cx36-containing gap junctions in generating aberrant activity in RD.

  8. The results suggest that electrical synapses formed by Cx36-containing gap junctions occur in most of the widely distributed centers of the auditory system.

  9. The resilts of this study showed that the phosphorylation state of Cx36 as a key biochemical step at the crossroad of light-dark and circadian regulatory pathways that control photoreceptor coupling.

  10. The magnitudes of the 2f1-f2 distortion products were not different between Cx36 knockout and wild-type mice, suggesting similar cochlear function in the two groups

  11. Mg(2+)-dependent synaptic plasticity of Cx36-containing electrical synapses could underlie neuronal circuit reconfiguration via changes in brain energy metabolism that affects neuronal levels of intracellular ATP and [Mg(2+)]i.

  12. Gene expression data indicate that EPCs, or their soluble products, modulate the expression of the beta-cell surface molecule connexin 36 and affect glucose-stimulated insulin release in vitro.

  13. Some neurons exhibit at least two discriminatory mechanisms for assembling Cx36 into gap junctions.

  14. The Cx36 was expressed in the mouse carotid body and in the intestine at ileum and colon level.

  15. The results indicate the presence of Cx36-containing gap junctions in the sexually dimorphic dorsomedial nucleus and dorsolateral nucleus of both male and female rodents

  16. The genetic deletion of the GJ subunit Cx36 increased cell survivability by approximately 50% under excitotoxic condition.

  17. Data (including data from studies in knockout mice) suggest that Cx36/Gjd2 gap junction channels are necessary for full up-regulation of insulin secretion by islet cells; mice with defective Cx36/Gjd2 expression exhibit glucose intolerance.

  18. knockout of Cx36 in mice with ATP-insensitive KATP channels restores glucose homeostasis and normal insulin secretion.

  19. Because Cx36 expression and function is reduced in type 2 diabetes, the resulting defect in intraislet blood cell flow regulation may also play a significant role in diabetic pathology.

  20. This study demonistrated that regulation of interneuron excitability by gap junction which containing Gjd2 coupling with principal cells in mice.

Gap Junction Protein, delta 2, 36kDa (GJD2) Protein Profile

Protein Summary

This gene encodes a member of the connexin protein family. Connexins are gap junction proteins which are arranged in groups of 6 around a central pore to form a connexon, a component of the gap junction intercellular channel. The channels formed by this protein allow cationic molecule exchange between human beta cells and may function in the regulation of insulin secretion.

Gene names and symbols associated with GJD2

  • gap junction protein delta 2 (GJD2)
  • gap junction protein, delta 2 (Gjd2)
  • gap junction protein delta 2 (Gjd2)
  • connexin36 protein
  • Cx35.1 protein
  • cx36 protein
  • Gja9 protein
  • GJD2 protein

Protein level used designations for GJD2

connexin 36 , connexin-36 , gap junction alpha-9 protein , gap junction delta-2 protein , connexin 35.1 , gap junction channel-forming protein , gap junction membrane channel protein alpha 9 , gap junction protein, alpha 9, 36kDa , gap junction protein, alpha 9, 59kDa , gap junction protein, delta 2, 36kDa , gap junction protein, alpha 9

57369 Homo sapiens
395273 Gallus gallus
282577 Bos taurus
453306 Pan troglodytes
487477 Canis lupus familiaris
697250 Macaca mulatta
100220961 Taeniopygia guttata
100341036 Oryctolagus cuniculus
100603227 Nomascus leucogenys
14617 Mus musculus
50564 Rattus norvegicus
100731673 Cavia porcellus
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