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Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Additionally we are shipping General Transcription Factor IIE, Polypeptide 1, alpha 56kDa Proteins (10) and and many more products for this protein.
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The N-terminal highly acidic region of TFIIEalpha interacts with the pleckstrin homology domain of TFIIH and adopts an extended stringlike structure on the positive groove of the pleckstrin homology domain with two hydrophobic amino acids, Phe387 and Val390, inserting into two shallow hydrophobic pockets of the pleckstrin homology domain.
The N-terminal half of TFIIEalpha forms an extended winged helix (WH) domain with an additional helix, followed by a zinc-finger domain. TFIIEbeta contains the WH2 domain, followed by two coiled-coil helices intertwining with TFIIEalpha.
Association of the winged helix motif of the TFIIEalpha subunit of TFIIE with either the TFIIEbeta subunit or TFIIB distinguishes its functions in transcription.
structural integrity of the zinc finger domain is essential for the TFIIE function
TFIIE is an alpha/beta heterodimer in solution. A model for the quaternary architecture of the complex is proposed that provides a structural framework to discuss the function of TFIIE in the context of RNA polymerase II transcription initiation.
interplay between TFIIEalpha and the tumor suppressor protein p53 in regulating transcriptional activation that may be modulated by the phosphorylation status of p53
The specific binding of the C-terminal acidic domain (AC-D) of the human TFIIEalpha subunit to the pleckstrin homology domain (PH-D) of the human TFIIH p62 subunit is demonstrated.
Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase (By similarity).
, general transcription factor II E, polypeptide 1 (alpha subunit, 56kDa)
, general transcription factor IIE 56 kDa subunit
, general transcription factor IIE subunit 1
, general transcription factor IIE, polypeptide 1 (alpha subunit, 56kDa)
, transcription initiation factor IIE subunit alpha
, general transcription factor IIE, polypeptide 1, alpha
, Transcription initiation factor IIE subunit beta
, general transcription factor IIE subunit 1 L homeolog
, general transcription factor IIE, polypeptide 1, alpha 56kDa