anti-General Transcription Factor III (GTF2I) Antibodies

GTF2I encodes a multifunctional phosphoprotein with roles in transcription and signal transduction. Additionally we are shipping GTF2I Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GTF2I 2969 P78347
GTF2I 353256 Q5U2Y1
GTF2I 14886 Q9ESZ8
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Top anti-GTF2I Antibodies at

Showing 10 out of 125 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB <b>WB Suggested Anti-GTF2I Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
Cow Rabbit Un-conjugated IHC, WB <b>WB Suggested Anti-GTF2I Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>293T cell lysate 100 μL Log in to see 2 to 3 Days
Dog Mouse Un-conjugated IF, WB Western blot analysis of TFII-I on HeLa cell lysate. Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of anti-TFII-I. Immunofluorescent staining of FHS cells. 50 μg Log in to see 6 to 8 Days
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from LOVO cells, using TFII-I (Phospho-Tyr248) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
Human Rabbit Un-conjugated EIA, WB   0.4 mL Log in to see 12 to 15 Days
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: TFII-I Antibody  - Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm. Western Blot: TFII-I Antibody  230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-578 0.1 mL Log in to see 10 to 13 Days
Human Rabbit Un-conjugated ICC, IF, IHC (p), IHC Immunohistochemistry-Paraffin: TFII-I Antibody [ABIN2531934] - FFPE section of mouse teratoma. Affinity purified rabbit anti-GTF2I/TFII-I used at a dilution of 1:100. 0.1 mL Log in to see 7 to 9 Days
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of various cells, using GTF2I antibody. Immunohistochemistry of paraffin-embedded mouse liver using GTF2I antibody. 100 μL Log in to see 16 Days
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western blot analysis of GTF2I Antibody (C-term) (ABIN390868) in Y79 cell line lysates (35 µg/lane). GTF2I (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain tissue reacted with GTF2I Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
Bat Rabbit Un-conjugated IHC (p), WB 50 μg Log in to see 7 to 9 Days

GTF2I Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , , ,
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Mouse (Murine) , , ,
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Top referenced anti-GTF2I Antibodies

  1. Dog (Canine) Monoclonal GTF2I Primary Antibody for IF, WB - ABIN968264 : Yang, Desiderio: BAP-135, a target for Bruton's tyrosine kinase in response to B cell receptor engagement. in Proceedings of the National Academy of Sciences of the United States of America 1997 (PubMed)

  2. Human Monoclonal GTF2I Primary Antibody for IF, IHC (p) - ABIN561180 : Poitras, Yu, Lesage-Pelletier, Macdonald, Gagné, Hatch, Kelly, Hamilton, Rubenstein, Poirier, Ekker: An SNP in an ultraconserved regulatory element affects Dlx5/Dlx6 regulation in the forebrain. in Development (Cambridge, England) 2010 (PubMed)

  3. Human Polyclonal GTF2I Primary Antibody for ICC, IF - ABIN4358737 : Lopez-Contreras, Ruppen, Nieto-Soler, Murga, Rodriguez-Acebes, Remeseiro, Rodrigo-Perez, Rojas, Mendez, Muñoz, Fernandez-Capetillo: A proteomic characterization of factors enriched at nascent DNA molecules. in Cell reports 2013 (PubMed)

  4. Cow (Bovine) Polyclonal GTF2I Primary Antibody for IHC, WB - ABIN2787508 : Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in Molecular systems biology 2007 (PubMed)

More Antibodies against GTF2I Interaction Partners

Human General Transcription Factor III (GTF2I) interaction partners

  1. GTF2I/Gtf2i, its physiologic role in human disorders was relatively unknown until recently. Novel studies show that it is involved in an array of human diseases including neurocognitive disorders, systemic lupus erythematosus (SLE), and cancer.

  2. the results reported here support a model whereby common genetic variation in GTF2I mediates human sociality and anxiety via effects on oxytocin reactivity.

  3. GTF2I mutations common in thymic epithelial tumors are not present/uncommon in hematological malignancies.

  4. The mis-regulation of genes downstream of GTF2IRD1, including TbetaR2 and BMPR1b, also individually promoted mammary cancer development, and silencing of TbetaR2 suppressed GTF2IRD1-driven tumor promotion.

  5. a new BRAF (show BRAF Antibodies) fusion in pilocytic astrocytoma

  6. A common polymorphism in the Williams syndrome gene GTF2I associated with reduced social anxiety predicts decreased threat-related amygdala reactivity, which mediates an association between genotype and increased warmth in women.

  7. We identified rs117026326 on GTF2I with GWAS significance (P = 1.10 x 10(-15)) and rs13079920 on RBMS3 (show RBMS3 Antibodies) with suggestive significance (P = 2.90 x 10(-5)) associating with Primary Sjogren's syndrome in women.

  8. The authors found that human adenovirus 5 infection or ectopic E4-ORF3 (show ASZ1 Antibodies) expression leads to SUMOylation of TFII-I that precedes a rapid decline in TFII-I protein levels.

  9. A novel interaction between TFII-I and Mdm2 (show MDM2 Antibodies) with a negative effect on TFII-I transcriptional activity has been documented.

  10. Copy-number variation in the general transcription factor gene, GTF2I is associated with gene-dose-dependent anxiety in mouse models and in both Williams syndrome and Dup7.

Mouse (Murine) General Transcription Factor III (GTF2I) interaction partners

  1. The Cre-mediated deletion of exon 3 recapitulates a genetic null phenotype, indicating that the conditional Gtf2i line is a valuable tool for studying TFII-I function during embryonic development

  2. found a highly conserved DNA element, common to a set of genes regulated by TFII-I, and identified and validated novel in vivo neuronal targets of this protein affecting the PI3K and TGFbeta (show TGFB1 Antibodies) signaling pathways

  3. GTF2IRD2 (show GTF2IRD2 Antibodies) has evolved as a regulator of GTF2IRD1 and TFII-I; inhibiting their function by direct interaction and sequestration into inactive nuclear zones.

  4. data support the hypothesis that upregulation of TFII-I factors leads to activation of a specific group of developmental genes during mESC differentiation

  5. GTF2I duplication results in separation anxiety in mice and humans

  6. In order to clarify the involvement of GTF2I in neurocognitive function, especially social behavior, we have developed and characterized Gtf2i-deficient mice.

  7. Results suggest that DJ-1 (show PARK7 Antibodies) together with TFII-I operate in concert to cope with various insults and to sustain pancreatic beta-cell function.

  8. behavioral characterization of heterozygous mice with a deletion of the first 140 amino-acids of TFII-I.

  9. data demonstrate that TFII-I, through a Src (show SRC Antibodies)-dependent mechanism, reversibly translocates from the cytoplasm to the nucleus, leading to the transcriptional activation of growth-regulated genes

  10. acts as a transcriptional cofactor for the SUMO ubiquitin-protein isopeptide ligase family member Miz1/PIASxbeta /Siz2 (show PIAS2 Antibodies)

GTF2I Antigen Profile

Protein Summary

The protein encoded by this gene contains five GTF2I-like repeats and each repeat possesses a potential helix-loop-helix (HLH) motif. It may have the ability to interact with other HLH-proteins and function as a transcription factor or as a positive transcriptional regulator under the control of Retinoblastoma protein. This gene plays a role in craniofacial and cognitive development and mutations have been associated with Williams-Beuren syndrome, a multisystem developmental disorder caused by deletion of multiple genes at 7q11.23. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with GTF2I

  • general transcription factor IIi (GTF2I) antibody
  • GTF2I repeat domain containing 1 (GTF2IRD1) antibody
  • general transcription factor II I (Gtf2i) antibody
  • general transcription factor IIi (gtf2i) antibody
  • general transcription factor IIi (Gtf2i) antibody
  • general transcription factor IIi S homeolog (gtf2i.S) antibody
  • 6030441I21Rik antibody
  • bap-135 antibody
  • bap135 antibody
  • BEN antibody
  • btkap1 antibody
  • CREAM1 antibody
  • diws antibody
  • gtf2i antibody
  • gtf2i.L antibody
  • Gtf2ird1 antibody
  • GTF3 antibody
  • gtfii-i antibody
  • hMusTRD1alpha1 antibody
  • ib291 antibody
  • MUSTRD1 antibody
  • RBAP2 antibody
  • spin antibody
  • tfii-i antibody
  • wbs antibody
  • wbscr6 antibody
  • WBSCR11 antibody
  • WBSCR12 antibody

Protein level used designations for GTF2I

BTK-associated protein, 135kD , Bruton tyrosine kinase-associated protein 135 , SRF-Phox1-interacting protein , Williams-Beuren syndrome chromosome region 6 , general transcription factor II-I , USE B1-binding protein , Williams-Beuren syndrome chromosome region 11 , binding factor for early enhancer , general transcription factor 3 , general transcription factor II-I repeat domain-containing protein 1 , general transcription factor III , muscle TFII-I repeat domain-containing protein 1 alpha 1 , slow-muscle-fiber enhancer-binding protein , williams-Beuren syndrome chromosomal region 12 protein , GTFII-I , TFII-I , BTK-associated protein 135 , general transcription factor II, i , general transcription factor IIi L homeolog , general transcription factor IIi S homeolog

2969 Homo sapiens
9569 Homo sapiens
353256 Rattus norvegicus
14886 Mus musculus
534669 Bos taurus
549986 Xenopus (Silurana) tropicalis
417486 Gallus gallus
479714 Canis lupus familiaris
100724513 Cavia porcellus
443780 Xenopus laevis
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