Germ Cell Associated 2 (Haspin) (GSG2) ELISA Kits

Fruit Fly (Drosophila melanogaster) Germ Cell Associated 2 (Haspin) (GSG2) interaction partners

1. These data provide insight into how Hasp and Hig construct the synaptic cleft matrix and regulate the differentiation of cholinergic synapses, and also illuminate a previously unidentified architecture within synaptic clefts

Human Germ Cell Associated 2 (Haspin) (GSG2) interaction partners

1. The results indicate a kinase-dependent role for Haspin in antagonizing Wapl and protecting centromeric cohesion in mitosis.

2. The mitotic histone kinase Haspin binds to the cohesin regulatory subunit Pds5B through a conserved YGA/R motif in its non-catalytic N terminus, which is similar to the recently reported YSR-motif-dependent binding of Wapl to Pds5B.

3. The authors' data identify the HIM of Pds5 as a binding motif for Haspin/Hrk1 in fission yeast. The authors' analyses also show that human PDS5B binds Haspin through the same HIM-PIM interaction module, indicating that the Haspin localization mechanism is highly conserved.

4. Autosomal recessive RP associated with mutations in the male germ cell-associated kinase (MAK) gene is associated with preservation of foveal vision even in advanced stages of retinal degeneration despite similar rates of peripheral visual field loss to other forms of autosomal recessive RP

5. This is the first structural model of a bisubstrate inhibitor targeting haspin. The presented structural data represent a model for the future development of more specific haspin inhibitors

6. Haspin kinase plays a key role in maintaining the slowly exchanging centromere Borealin pool.

7. Haspin activity affects the phosphorylation state of proteins involved in gene expression regulation and splicing.

8. Haspin inhibitors reveal centromeric roles of Aurora B in chromosome movement and spindle checkpoint signaling

9. Aurora B phosphorylates Haspin to promote generation of H3T3ph and that Aurora B kinase activity is required for normal chromosomal localization of the CPC, indicating an intimate linkage between Aurora B and Haspin functions in mitosis

10. findings show phosphorylation of histone H3-threonine 3 mediated by Haspin cooperates with Bub1-mediated histone 2A-serine 121 phosphorylation in targeting the chromosomal passenger complex to the inner centromere in fission yeast and human cells

11. phosphorylation of H3T3 by Haspin is necessary for chromosomal passenger complex(CPC) accumulation at centromeres; Survivin binds to H3T3ph; H3T3ph generated by Haspin positions CPC at centromeres to regulate selected targets of Aurora B during mitosis

12. Haspin-depleted cells reveal that spindle-pole integrity in mitosis requires chromosome cohesion.

13. Haspin is a relatively newly discovered kinase that phosphorylates histone H3 during mitosis and appears to play a role in regulating chromosome behavior during cell division. [REVIEW]

14. This work reveals a new kinase involved in composing the histone code and adds haspin to the select group of kinases that integrate regulation of chromosome and spindle function during mitosis and meiosis

15. Haspin is required to maintain centromeric cohesion during mitosis.

Mouse (Murine) Germ Cell Associated 2 (Haspin) (GSG2) interaction partners

1. These data uncover a role for haspin as a regulator of bipolar spindle assembly by regulating AURKC function at acentriolar microtubule-organizing centers in oocytes.

2. Data implicate haspin as a regulator of the chromosomal passenger complex and chromosome segregation during meiosis I.

3. the tissue-dependent and differentially methylated region functions as a modulator in a DNA methylation-dependent manner; Gsg2 is under epigenetic control

4. the 193-bp DNA sequence in Haspin promotor is sufficient for the specific, bidirectional, and synchronous expression in germ cells in the testis.