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Plays a role in the formation of the nodes of Ranvier along myelinated axons. Additionally we are shipping GLDN Antibodies (39) and GLDN Kits (2) and many more products for this protein.
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Our findings expand the genotypic and phenotypic spectrum of LCCS11 and demonstrate that the condition may not necessarily be lethal in the neonatal period.
data indicate that mutations of GLDN or CNTNAP1 (MIM: 616286), encoding essential components of the nodes of Ranvier and paranodes, respectively, lead to inherited nodopathies, a distinct disease entity among peripheral neuropathies
gliomedin, NF186, and contactin are novel target antigens in Guillain-Barre syndrome
Fibronectin type III-like domains of neurofascin-186 protein mediate gliomedin binding and its clustering at the developing nodes of Ranvier
OLF domains from H. sapiens olfactomedin-1 and M. musculus gliomedin were biophysically, biochemically, and structurally characterized.
Perlecan binds the clustering molecule gliomedin and enhances clustering of node of Ranvier components.
Here, we show that initial clustering of Na(+) channels at heminodes requires glial NrCAM and gliomedin, as well as their axonal receptor neurofascin 186 (NF186).
Plays a role in the formation of the nodes of Ranvier along myelinated axons. Probable NRCAM and NFASC/neurofascin ligand which may provide a glial positional clue required for the proper molecular assembly of the nodes of Ranvier (By similarity).
, cancer related gene - liver 2
, cancer-related gene liver 2 protein
, olfactomedin-related protein